Pine bark extract may ease hemorrhoid problems
Pine bark extract may ease hemorrhoid problems
By Stephen Daniells, 12-Jan-2010
Related topics: Botanicals, Research, Antioxidants, carotenoids, Phytochemicals, plant extracts
Supplements of French maritime pine bark extract may reduce the intensity and duration of hemorrhoidal pain and bleeding, says a new study.
A daily supplement of the pine bark extract, Pycnogenol, for seven days reduced pain around the anus from an initial average of 3.2 points on a four-point pain scale to about 0.8 at the end of the study, according to findings published in Phytotherapy Research.
Considering that over 50 per cent of the population will suffer from hemorrhoids at some point in their lives, the potential of the French maritime pine bark extract to ease the condition would indicate a major market opportunity.
“This study clearly indicates that Pycnogenol is an effective, natural solution in controlling this common, disabling problem and may contribute to relieve hemorrhoid attacks and offer pain relief,” said lead researcher Professor Peter Rohdewald from the University of Munster in Germany.
"Individuals never affected by hemorrhoids cannot imagine what people go through. Hemorrhoids can affect every aspect of your daily routine; it represents a tragedy most people don't realize. Our study suggests that Pycnogenol may help with all major symptoms,” he added.
Prof Rohdewald said that further studies are in progress with the focus on preventing new attacks and the general management of hemorrhoids.
Study details
In collaboration with Italian scientists from G D’Annunzio University, the researchers recruited 84 people suffering from external hemorrhoids to participate in their randomized, controlled, comparative study.
Subjects were divided into three groups: Group 1 received a daily oral dose of 300 mg of the pine bark extract for four days, followed by 150 mg a day another three days; Group 2 received the same oral doses as Group 1, plus a topical cream containing 0.5 per cent Pycnogenol; and Group 3 received a placebo.
Improvements in both groups 1 and 2 were observed at the end of the study. No hemorrhoid bleedings was observed in the two Pycnogenol groups after seven days, said the researchers. Bleeding was still observed in the placebo group, they added.
In addition to the decreases in peri-anal pain in group 1, group 2 participants reported a decrease from an initial score of 3.3 out of four to 0.3 at the end of the study. The placebo group reported a decrease from 3.4 to 1.2.
Finally, a decrease in the number of lost working days was recorded by the subjects, while there was also a reduction in the recurrence of complications and overall costs in both groups receiving the pine bark extract.
What’s happening?
Commenting on the possible mechanism, the researchers noted that the flavonoid profile of the pine bark extract may be behind the effects. “Unlike other flavonoid species, Pycnogenol significantly improves endothelial function which could contribute to the decreased ischemia (inadequate blood supply) and intravascular thrombus (clotting) found in our study,” they stated.
The study was funded by Horphag Research, manufacturers of Pycnogenol. The company has been very active in sponsoring and supporting studies into the potential health benefits of the pine bark extract. The first research was conducted on the ingredient 35 years ago.
Source: Phytotherapy Research
Published online ahead of print, Early View article, doi:
“Pycnogenol treatment of acute hemorrhoidal episodes”
Authors: G. Belcaro, M.R. Cesarone, B. Errichi, A. Di Renzo, M.G. Grossi, A. Ricci, M. Dugall, U. Cornelli, M. Cacchio, P. Rohdewald
Isotonix Opc-3 - Single Bottle (90 Servings)
Monday, January 18, 2010
Wednesday, January 13, 2010
Multivitamins may cut lung cancer risk in smokers
Multivitamins may cut lung cancer risk in smokers
Multivitamins may cut lung cancer risk in smokers
By Stephen Daniells, 13-Jan-2010
Related topics: Research, Antioxidants, carotenoids, Phytochemicals, plant extracts, Vitamins & premixes, Cancer risk reduction
Multivitamins, folate, and green leafy vegetables may reduce the risk of developing lung cancer in current and former smokers, says a new study from the US.
Higher intakes of certain micronutrients may reduce a process called methylation which affects gene signaling. Many genes involved in critical cell functions, including cell division, are methylated in lung tumours, showing the potential of the micronutrients to reduce the risk of lung cancer, according to findings published online ahead of print in Cancer Research.
The role of micronutrients in smokers is controversial with some studies; most notably the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Trial, reporting that beta-carotene supplements may increase the risk of lung cancer.
The new study, supported by the US National Cancer Institute (NCI), part of the National Institutes of Health, showed that reduced gene methylation with the intake of multivitamin supplements that are rich in phytochemicals, such as vitamin C, carotenoids, lutein, folic acid, and vitamins A and K. Such micronutrients are also present green leafy vegetables.
“This is the first cohort-based study to identify dietary factors associated with reduced promoter methylation in cells exfoliated from the airway epithelium of smokers,” wrote the researchers, led by Steven Belinsky, PhD, from the Lovelace Respiratory Research Institute in Albuquerque.
“Novel interventions to prevent lung cancer should be developed based on the ability of diet and dietary supplements to affect reprogramming of the epigenome,” they added.
‘Impressive’ study
Commenting independently on the study, a spokesperson for ingredient supplier DSM told NutraIngredients that the study illustrates how complex micronutrient research is.
“It impressively shows, for example, that supplements containing beta-carotene, conceivably increasing the risk of lung cancer in heavy smokers when taken in extremely high doses over years, have the potential to reduce cancer risk even in smokers,” said the spokesperson.
“Additionally, the study is further evidence that nature-identical, synthetic micronutrients in multivitamins can be effective in disease risk reduction as micronutrients from vegetables and fruits.”
Study details
Just over 1,100 current and former smokers participating in the Lovelace Smokers Cohort submitted sputum samples and completed questionnaires regarding their dietary intake. The sputum samples were used to examine the degree of methylation of eight genes commonly silenced in lung cancer and associated with risk for this disease.
People who ate at least 12 servings of green leafy vegetables per month had a 17 per cent lower risk of methylation, while a daily folate intake of at least 750 micrograms was associated with a 16 per cent lower risk.
Current multivitamin users had a 43 per cent lower risk of gene methylation, added the researchers, although there was no association between the duration of use and methylation..
More research needed
Sudhir Srivastava, PhD, chief of the Biomarkers Research Group at the NCI called for additional research to independently validate the study’s observations, and also to help resolve contradictions between varying studies.
“This particular study used a well-planned design and can serve as a basis for future identification of the mechanistic targets of these dietary factors,” said Srivastava, who was not involved in the study.
“Such studies are important steps for the future success of chemopreventive strategies.”
Source: Cancer Research
Published online ahead of print, doi: 10.1158/0008-5472.CAN-09-3410
“Multi-Vitamins, Folate, and Green Vegetables Protect Against Gene Promoter Methylation in the Aerodigestive Tract of Smokers”
Authors: C.A. Stidley, M.A. Picchi, S. Leng, R. Willink, R. Crowell, F.G. Flores, H. Kang, T. Byers, F.D. Gilliland, S.A. Belinsky
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Multivitamins may cut lung cancer risk in smokers
By Stephen Daniells, 13-Jan-2010
Related topics: Research, Antioxidants, carotenoids, Phytochemicals, plant extracts, Vitamins & premixes, Cancer risk reduction
Multivitamins, folate, and green leafy vegetables may reduce the risk of developing lung cancer in current and former smokers, says a new study from the US.
Higher intakes of certain micronutrients may reduce a process called methylation which affects gene signaling. Many genes involved in critical cell functions, including cell division, are methylated in lung tumours, showing the potential of the micronutrients to reduce the risk of lung cancer, according to findings published online ahead of print in Cancer Research.
The role of micronutrients in smokers is controversial with some studies; most notably the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Trial, reporting that beta-carotene supplements may increase the risk of lung cancer.
The new study, supported by the US National Cancer Institute (NCI), part of the National Institutes of Health, showed that reduced gene methylation with the intake of multivitamin supplements that are rich in phytochemicals, such as vitamin C, carotenoids, lutein, folic acid, and vitamins A and K. Such micronutrients are also present green leafy vegetables.
“This is the first cohort-based study to identify dietary factors associated with reduced promoter methylation in cells exfoliated from the airway epithelium of smokers,” wrote the researchers, led by Steven Belinsky, PhD, from the Lovelace Respiratory Research Institute in Albuquerque.
“Novel interventions to prevent lung cancer should be developed based on the ability of diet and dietary supplements to affect reprogramming of the epigenome,” they added.
‘Impressive’ study
Commenting independently on the study, a spokesperson for ingredient supplier DSM told NutraIngredients that the study illustrates how complex micronutrient research is.
“It impressively shows, for example, that supplements containing beta-carotene, conceivably increasing the risk of lung cancer in heavy smokers when taken in extremely high doses over years, have the potential to reduce cancer risk even in smokers,” said the spokesperson.
“Additionally, the study is further evidence that nature-identical, synthetic micronutrients in multivitamins can be effective in disease risk reduction as micronutrients from vegetables and fruits.”
Study details
Just over 1,100 current and former smokers participating in the Lovelace Smokers Cohort submitted sputum samples and completed questionnaires regarding their dietary intake. The sputum samples were used to examine the degree of methylation of eight genes commonly silenced in lung cancer and associated with risk for this disease.
People who ate at least 12 servings of green leafy vegetables per month had a 17 per cent lower risk of methylation, while a daily folate intake of at least 750 micrograms was associated with a 16 per cent lower risk.
Current multivitamin users had a 43 per cent lower risk of gene methylation, added the researchers, although there was no association between the duration of use and methylation..
More research needed
Sudhir Srivastava, PhD, chief of the Biomarkers Research Group at the NCI called for additional research to independently validate the study’s observations, and also to help resolve contradictions between varying studies.
“This particular study used a well-planned design and can serve as a basis for future identification of the mechanistic targets of these dietary factors,” said Srivastava, who was not involved in the study.
“Such studies are important steps for the future success of chemopreventive strategies.”
Source: Cancer Research
Published online ahead of print, doi: 10.1158/0008-5472.CAN-09-3410
“Multi-Vitamins, Folate, and Green Vegetables Protect Against Gene Promoter Methylation in the Aerodigestive Tract of Smokers”
Authors: C.A. Stidley, M.A. Picchi, S. Leng, R. Willink, R. Crowell, F.G. Flores, H. Kang, T. Byers, F.D. Gilliland, S.A. Belinsky
You may get an Isotonic form of ACAI at Market America
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Acai benefits cholesterol levels: Rat study
Acai benefits cholesterol levels: Rat study
Acai benefits cholesterol levels: Rat study
By Stephen Daniells, 05-Jan-2010
Related topics: Research, Antioxidants, carotenoids, Phytochemicals, plant extracts, Cardiovascular health
The pulp of açai berries may counter the effects of a high-fat diet and reduce the risk of developing high blood cholesterol levels, says a new study with rats from Brazil.
Animals fed a high-fat diet and supplemented with açai pulp had lower levels of total and non-HDL cholesterol, compared to animals just eating a high-fat diet, according to findings published in Nutrition.
“This is the first study, to our knowledge, addressing the potential benefits of açai intake in the cholesterol profile,” wrote the researchers, led by Maria Lucia Pedrosa from the Federal University of Ouro Preto.
“We observed that the addition of açai pulp in the hypercholesterolemic diet had a hypocholesterolemic effect by reducing cholesterol levels (total and non-HDL), which could be explained by a lower food intake and higher faecal excretion,” they added.
High cholesterol levels, hypercholesterolaemia, have a long association with many diseases, particularly cardiovascular disease (CVD), the cause of almost 50 per cent of deaths in Europe, and reported to cost the EU economy an estimated €169bn ($202bn) per year.
Super fruits from Central and South America
Açai berries (pronounced ah-sigh-ee) have long formed part of the staple diet of Indian tribes. With the appearance of a purple grape and taste of a tropical berry, it has been shown to have powerful antioxidant properties thanks to a high level of anthocyanins, pigments that are also present in red wine.
It is presently being sold in a number of countries, including New Zealand, Australia, South America, Japan, USA, and the Middle East
Commenting independently on the study, açai expert Dr Alex Schauss from US-based contract research organization AIBMR told NutraIngredients that the study does provide in vivo experimental evidence that açai pulp can improve mammalian lipid profiles in response to a high fat diet.
Regarding the safety data, Dr Schauss added that “açai does not appear to cause liver damage as evidenced by the fact that açai does not alter activities of several liver enzymes. This is important since liver damage is a common phenomenon when a drug is taken for a long period of time.”
Study details
Pedrosa and her co-workers used female Fischer rats and divided them into four groups: Two groups consumed a standard diet, and two groups consumed a high fat diet containing 25 per cent soy oil and 1 per cent cholesterol. One standard diet group and one high fat diet group received additional açai pulp at a level of 2 per cent.
After six weeks, the researchers noted an increase in blood levels of total and non-HDL cholesterol and a decrease in levels of HDL cholesterol in the high-fat diet only animals. Such changes were attenuated in the açai-supplemented high-fat diet animals.
The researchers did not directly examine the mechanism behind the effects but noted that the benefits may not be solely due to the polyphenol content of the fruit.
“These results suggest that the consumption of açai improves antioxidant status and has a hypocholesterolemic effect in an animal model of dietary-induced hypercholesterolemia,” concluded the researchers.
Future study
AIBMR’s Dr Schauss noted that future studies should focus on using a better high fat mouse model. “There is a published rodent diet that is close to a typical high fat American diet or McDonald diet that could be used,” he said. He also said that the length of intervention should be increased to six months, while the effects of açai pulp on lipids can be further investigated by looking at both liver and blood vessel morphology, signalling pathways, LDL levels and cardiovascular functions.
Source: Nutrition
Published online ahead of print, doi: 10.1016/j.nut.2009.09.007
“Diet supplementation with açai (Euterpe oleracea Mart.) pulp improves biomarkers of oxidative stress and the serum lipid profile in rats”
Authors: M. Oliveira de Souza, M. Silva, M. Eustaquio Silva, R. de Paula Oliveira, M.L. Pedrosa
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Acai benefits cholesterol levels: Rat study
By Stephen Daniells, 05-Jan-2010
Related topics: Research, Antioxidants, carotenoids, Phytochemicals, plant extracts, Cardiovascular health
The pulp of açai berries may counter the effects of a high-fat diet and reduce the risk of developing high blood cholesterol levels, says a new study with rats from Brazil.
Animals fed a high-fat diet and supplemented with açai pulp had lower levels of total and non-HDL cholesterol, compared to animals just eating a high-fat diet, according to findings published in Nutrition.
“This is the first study, to our knowledge, addressing the potential benefits of açai intake in the cholesterol profile,” wrote the researchers, led by Maria Lucia Pedrosa from the Federal University of Ouro Preto.
“We observed that the addition of açai pulp in the hypercholesterolemic diet had a hypocholesterolemic effect by reducing cholesterol levels (total and non-HDL), which could be explained by a lower food intake and higher faecal excretion,” they added.
High cholesterol levels, hypercholesterolaemia, have a long association with many diseases, particularly cardiovascular disease (CVD), the cause of almost 50 per cent of deaths in Europe, and reported to cost the EU economy an estimated €169bn ($202bn) per year.
Super fruits from Central and South America
Açai berries (pronounced ah-sigh-ee) have long formed part of the staple diet of Indian tribes. With the appearance of a purple grape and taste of a tropical berry, it has been shown to have powerful antioxidant properties thanks to a high level of anthocyanins, pigments that are also present in red wine.
It is presently being sold in a number of countries, including New Zealand, Australia, South America, Japan, USA, and the Middle East
Commenting independently on the study, açai expert Dr Alex Schauss from US-based contract research organization AIBMR told NutraIngredients that the study does provide in vivo experimental evidence that açai pulp can improve mammalian lipid profiles in response to a high fat diet.
Regarding the safety data, Dr Schauss added that “açai does not appear to cause liver damage as evidenced by the fact that açai does not alter activities of several liver enzymes. This is important since liver damage is a common phenomenon when a drug is taken for a long period of time.”
Study details
Pedrosa and her co-workers used female Fischer rats and divided them into four groups: Two groups consumed a standard diet, and two groups consumed a high fat diet containing 25 per cent soy oil and 1 per cent cholesterol. One standard diet group and one high fat diet group received additional açai pulp at a level of 2 per cent.
After six weeks, the researchers noted an increase in blood levels of total and non-HDL cholesterol and a decrease in levels of HDL cholesterol in the high-fat diet only animals. Such changes were attenuated in the açai-supplemented high-fat diet animals.
The researchers did not directly examine the mechanism behind the effects but noted that the benefits may not be solely due to the polyphenol content of the fruit.
“These results suggest that the consumption of açai improves antioxidant status and has a hypocholesterolemic effect in an animal model of dietary-induced hypercholesterolemia,” concluded the researchers.
Future study
AIBMR’s Dr Schauss noted that future studies should focus on using a better high fat mouse model. “There is a published rodent diet that is close to a typical high fat American diet or McDonald diet that could be used,” he said. He also said that the length of intervention should be increased to six months, while the effects of açai pulp on lipids can be further investigated by looking at both liver and blood vessel morphology, signalling pathways, LDL levels and cardiovascular functions.
Source: Nutrition
Published online ahead of print, doi: 10.1016/j.nut.2009.09.007
“Diet supplementation with açai (Euterpe oleracea Mart.) pulp improves biomarkers of oxidative stress and the serum lipid profile in rats”
Authors: M. Oliveira de Souza, M. Silva, M. Eustaquio Silva, R. de Paula Oliveira, M.L. Pedrosa
You may get an Isotonic form of ACAI at Market America
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Have you been Customized?
Pycnogenol pine bark extract shown to protect diabetics from swelling, circulation and vision problems
NaturalNews) A research study conducted by G D'Annunzio University in Italy evaluated the benefits of a popular form of pine bark extract in helping diabetics. Published in the Journal of Ocular Pharmacology and Therapeutics, findings revealed that people with diabetes can avoid developing retinopathy and maintain proper micro-circulation by supplementing with pine bark.
A total of 46 diabetic patients were involved in the randomized, controlled study. Twenty-four of them were treated with pine bark extract once a day for three months while the remaining 22 were given a placebo. All the patients had diabetes for at least four years and all were beginning to develop retinopathy. Seventy-five percent of patients in the pine bark group experienced improvement in their vision while none in the placebo group did.
Dr. Robert Steigerwalt, one of the lead researchers of the study, confirmed that not only does pine bark extract halt the progression of diabetic retinopathy, it can cause it to regress by sealing the leaky blood vessels in the eye that lead to the disease. Such results were witnessed in as little as two months. He also noted that diabetics in the early stages of the disease can prevent such complications from ever occurring by supplementing with pine bark extract.
Pycnogenol, the branded formula of the antioxidant plant extract derived from the French maritime pine tree, has proven itself time and time again to be a powerful protective nutrient, particularly for diabetics. When administered during the early stages of diabetes, many studies have shown that pine bark is effective at preventing and treating the diabetic retinal diseases.
Comments by Mike Adams, the Health Ranger
Pycnogenol is one of the "miracle nutrients" we've been blessed with on this planet. Time and time again, it has been proven to offer truly remarkable health benefits to those people who taken the supplement.
Now, this research shows how beneficial pycnogenol can be for diabetics. It's an important piece of research showing how this tree-derived nutrient helps increase circulation that can ultimately help save lives.
It's not just an antioxidant, you see: It's also a potent circulation booster. Combined with other circulation-boosting herbs like ginger and ginkgo, it could be an extremely effective natural remedy for preventing diabetic neuropathy (degradation of the nerves) and retinopathy (degradation of the retina).
Pycnogenol is just One of the three main ingredients in Market America's OPC-3
www.customizeme.com
A total of 46 diabetic patients were involved in the randomized, controlled study. Twenty-four of them were treated with pine bark extract once a day for three months while the remaining 22 were given a placebo. All the patients had diabetes for at least four years and all were beginning to develop retinopathy. Seventy-five percent of patients in the pine bark group experienced improvement in their vision while none in the placebo group did.
Dr. Robert Steigerwalt, one of the lead researchers of the study, confirmed that not only does pine bark extract halt the progression of diabetic retinopathy, it can cause it to regress by sealing the leaky blood vessels in the eye that lead to the disease. Such results were witnessed in as little as two months. He also noted that diabetics in the early stages of the disease can prevent such complications from ever occurring by supplementing with pine bark extract.
Pycnogenol, the branded formula of the antioxidant plant extract derived from the French maritime pine tree, has proven itself time and time again to be a powerful protective nutrient, particularly for diabetics. When administered during the early stages of diabetes, many studies have shown that pine bark is effective at preventing and treating the diabetic retinal diseases.
Comments by Mike Adams, the Health Ranger
Pycnogenol is one of the "miracle nutrients" we've been blessed with on this planet. Time and time again, it has been proven to offer truly remarkable health benefits to those people who taken the supplement.
Now, this research shows how beneficial pycnogenol can be for diabetics. It's an important piece of research showing how this tree-derived nutrient helps increase circulation that can ultimately help save lives.
It's not just an antioxidant, you see: It's also a potent circulation booster. Combined with other circulation-boosting herbs like ginger and ginkgo, it could be an extremely effective natural remedy for preventing diabetic neuropathy (degradation of the nerves) and retinopathy (degradation of the retina).
Pycnogenol is just One of the three main ingredients in Market America's OPC-3
www.customizeme.com
Tuesday, January 05, 2010
Isotonix Opc-3 - Single Bottle (90 Servings)
Isotonix Opc-3 - Single Bottle (90 Servings)
Primary Benefits:
° Combats free radicals
° Demonstrates anti-inflammatory activity
° Helps maintain healthy cholesterol levels
° Helps maintain healthy circulation by strengthening capillaries, arteries and veins
° Helps maintain joint flexibility
° Helps promote/support cardiovascular health
° Helps reduce mild menstrual cramping and abdominal pain
° Helps support visual health/visual acuity
° Potent free radical scavenger
° Promotes/Supports healthy blood vessel dilation
° Promotes/Supports healthy nitric oxide levels
° Supports a healthy complexion
° Supports healthy blood glucose levels
° Supports healthy platelet activity
° Supports healthy sperm quality
Key Ingredients:
Grape Seed Extract : 25 mg
Grape seed extract is typically extracted from the seeds of red grapes (instead of white), which have a high content of compounds known as oligomeric proanthocyanidins (OPCs). Grape seed extract is extremely rich in polyphenols, compounds with high antioxidant activity. Grape seed extract has been found to maintain healthy cholesterol levels.
Red Wine Extract: 25 mg
Red wine extract is a potent antioxidant. This extract is found in grape vines, roots, seeds and stalks, with the highest concentration in the skins. The antioxidant properties of red wine extract contribute to maintaining healthy circulation by strengthening capillaries, arteries and veins, and promoting overall cardiovascular health.
In the late 1990s, scientists took note of a phenomenon among the French. There were very low rates of cardiovascular problems in the provinces where residents consistently ate high fat foods and drank red wine. Scientists concluded that the protective properties of red wine have helped the French maintain cardiovascular health for years and subsequent scientific studies have further shown that the OPCs found in red wine are particularly beneficial for protecting the heart and blood vessels.
Pine Bark Extract (Pycnogenol®): 25 mg
Pycnogenol is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. This unspoiled and natural forest environment is the unique source of pine bark. Pycnogenol is one of the most researched ingredients in the natural product marketplace. Published findings have demonstrated Pycnogenol’s wide array of beneficial effects on the body. Pine bark extract is an all natural combination of procyanidins, bioflavonoids and organic acids.
The extract has four basic properties — it is a powerful antioxidant, acts as a natural anti-inflammatory, selectively binds to collagen and elastin, and aids in the production of endothelial nitric oxide, which helps to dilate blood vessels.
As one of the most potent natural scavenger of free radicals, Pycnogenol combats many aggressive free radicals before they cause oxidative stress to vital organs. Its super-antioxidant capabilities help support healthy blood platelet activity, support healthy blood glucose levels, reduce mild menstrual cramping and abdominal pain, maintain joint flexibility, promote cardiovascular health, promote healthy sperm quality, maintain healthy cholesterol levels and support a healthy complexion.
Bilberry Extract : 25 mg
Bilberry extract is derived from the leaves and berry-like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins, which are powerful antioxidants. Scientific studies confirm that bilberry extract supports healthy vision and venous circulation. Bilberry extract helps maintain healthy circulation by strengthening capillaries, arteries and veins.
Citrus Extract (Bioflavonoids): 25 mg
Bioflavonoids are antioxidants found in certain plants that act as light filters, which protect delicate DNA chains and other important macromolecules by absorbing ultraviolet radiation. They have been found to promote cardiovascular health, help maintain healthy circulation by strengthening capillaries, arteries and veins, and demonstrate anti-inflammatory activity.
Grape Seed Extract for Blood Pressure?
Study: Grape Seed Extract May Help Tame Prehypertension By Miranda Hitti
WebMD Medical News
Reviewed By Louise Chang, MD
on Monday, March 27, 2006
SOURCES: American Chemical Society National Meeting & Exposition,Atlanta, March 26-30, 2006. Tissa Kappagoda, MD, PhD, professor of internal medicine (cardiovascular medicine), University of California, Davis. News release, University of California, Davis. News release, American Chemical Society.
Grape and Salicin-Rich Extracts for Cardiovascular Disease Prevention
HerbalGram. 2004;63:25 © American Botanical Council
Supplement Speeds Wound Healing
Antioxidant Cocktail Contains 4 Skin-Friendly Substances
By Sid Kirchheimer
WebMD Medical News
Reviewed By Brunilda Nazario, MD
on Thursday, July 08, 2004
The effect of polyphenolic extract from pine bark, Pycnogenol on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD). Redox Rep. 2006;11(4):163-72.
Nonalcoholic Red Wine Extract and Quercetin Inhibit LDL Oxidation without Affecting Plasma Antioxidant Vitamin and Carotenoid Concentrations
(Clinical Chemistry. 2000;46:1162-1170.)
© 2000 American Association for Clinical Chemistry, Inc.
Pycnogenol reduces osteoarthritis pain, study
Scientific Studies:
o Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000.
o Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994.
o Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000.
o Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY Academy of Sciences 928: 141-156, 2001.
o Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
o Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
o Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
o Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
o Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
o Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
o Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
o Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh
o Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999.
o Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
o Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
o Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
o Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
o Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
o Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
o Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
o Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004.
o Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
o Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
o Rohdewald, P. Pycnogenol®. In "Flavonoids in Health and Disease". Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19.
o Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
o Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999.
o Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998.
o Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.
o Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
o Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
o Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
o Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001.
o Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.
o Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.
o Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.
o Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
o Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
o Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
o Yamakoshi, J., et al. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149, 1999.
o Ames, BN, et al. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922, 1993.
o Bagchi, D, et al. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95:179-89, 1997.
o Bagchi, D, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148: 187-97, 2000.
o Bagchi, D, et al. Cellular protection with proanthocyanidins derived from grape seed. Ann NY Acad Sci 957:260-70, 2002.
o Cao G, Alessio H, Cultler R. Oxygen-radical absorbance capacity assay for antioxidants. Fre Rad Biol & Med 14:301-11, 1993.
o Drew B, Leeuwenburgh C. Aging and the role of reactive nitrogen species. Ann NY Acad Sci 959:66-81, 2002.
o Gibson, L, et al. Effectiveness of cranberry juice in preventing urinary tract infections in long-term care facility patients. J Naturopathic Med 2:45-47, 1991.
o Graham DY, Smith JL, Bouvet, AA. What happens to tablets in the stomach. J Pharm Sci 79:420-24, 1990.
o Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharm 32:1141-48, 1983.
o Halpern, MJ, et al. Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention. J Int Med Res 26:171-80, 1998.
o Joseph JA, Shukitt-Hale B, Denisova NA, Bielinksi D, Martin A, McEwen JJ, Bickford PC. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neuroscience 19: 8114-21, 1999.
o Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) on post-prandial serum antioxidant status in human subjects. Br J Nutr 88: 389-98, 2002.
o Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 23:21-48, 1993.
o Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency. Phytother Res 16:S1-5, 2002.
o Koparker AD, Augsburger LL, Shangraw RF. Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations. Pharm Res 7:80-85, 1990.
o Mazza G, Kay CD, Cottrell T, Holub BJ. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem 50:7731-37, 2002.
o Nesaretnam K, et al. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids 30:1139-43, 1995.
o Ofek I, Goldhar J, Zafriri D, Lis H, Sharon N. Anti-Escherichia coli adhesion activity of cranberry and blueberry juices. New England J Med 324:1599, 1991.
o Qureshi, A, et al. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids 30:1171-77, 1995.
o Rimbach G, Virgili F, Park YC, Packer L. Effect of procyanidins from Pinus maritime on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages. Redox Rep 4:171-77, 1999.
o Sobota AE. Inhibition of bacterial adherence by cranberry juice: potential use for the treatment of urinary tract infactions. J Urology 131:1013-1016, 1984.
o Soloway MS, Smith RA. J Am Med Assoc 260:1465, 1988.
o Tomco, A, et al. Antioxidant effects of tocotrienol in patients with hyperlipidemia and carotid stenosis. Lipids 30: 1179-83, 1995.
o Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51:502-9, 2003.
What Makes This Product Unique?
A free radical is an atomic structure with an unpaired electron in its outermost shell. These unpaired electrons tend to be highly reactive, resulting in chemical reactions such as oxidation. Because they have one or more unpaired electrons, free radicals are highly unstable. They scavenge the body to grab or donate electrons, causing damage to cells, proteins and DNA. Free radicals are naturally occurring; however, air pollution, stress, smoking, heavy exercising and aging all contribute to the creation of harmful free radicals. Free radicals can cause oxidative damage to the body, potentially leading to serious health problems. Normally the body is able to protect itself from the damaging effects of free radicals, but if antioxidants are unavailable, or if free radical production becomes excessive, damage can occur.
Antioxidants are natural cell protectors, neutralizing free radicals by pairing an electron to the outermost shell of radical oxygen molecules, rendering them harmless. Antioxidants are nutrients such as vitamins and minerals, and enzymes that are capable of counteracting the damaging, but normal, effects of the physiological process of oxidation in bodily tissues. Antioxidants work in two ways, chain breaking and prevention. A chain-breaking antioxidant such as vitamins A, C and E, stabilize free radicals or cause them to decay into harmless atomic structures. A preventative antioxidant prevents the oxidation process by scavenging free radicals.
Isotonix OPC-3® is an isotonic-capable food supplement that is made from a combination of bilberry, grape seed, red wine, pine bark extracts and citrus extract bioflavonoids, all found to be potent antioxidants. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body. Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. Isotonix OPC-3 contains the only isotonic form of Pycnogenol® in the world. Pycnogenol is a natural plant extract from the bark of the French maritime pine tree, and the most clinically researched and potent bioflavonoid.
Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state.
Isotonix® dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.
Frequently Asked Questions:
What is Isotonix OPC-3?
Isotonix OPC-3 is a dietary supplement that bears some of the most powerful bioflavonoids currently known to research scientists. These bioflavonoids are scientifically termed oligomeric proanthocyanidins, commonly abbreviated OPCs. The purest and best-researched OPCs chosen for OPC-3 are prepared from grape seed, red wine, bilberries, Pycnogenol from pine bark and citrus fruit. This combination of potent OPCs is unique to OPC-3, as is the Isotonix delivery system, which enables rapid and highly efficient absorption of the OPCs. Isotonix OPC-3 has been shown to provide a variety of health benefits including but not limited to combating free radicals, demonstrating anti-inflammatory activity, helping maintain healthy cholesterol levels, helping maintain healthy circulation by strengthening capillaries, arteries and veins, helping maintain joint flexibility, helping promote/support cardiovascular health, helping reduce mild menstrual cramping and abdominal pain, helping support visual health/visual acuity, scavenging free radicals, promoting/supporting healthy blood vessel dilation, promoting/supporting healthy nitric oxide levels, supporting a healthy complexion, supporting healthy blood glucose levels, supporting healthy platelet activity and supporting healthy sperm quality.
What is a bioflavonoid?
Bioflavonoids are complex organic plant compounds. Plants and fruits differ in colors based on the specific bioflavonoids they contain. An increasing number of clinical studies have shown how bioflavonoids support health. Bioflavonoids found in OPCs play a key role in cardiovascular health and maintaining vascular integrity. Bioflavonoids have been shown to demonstrate support for healthy circulation and cell vitality. Normal collagen renewal is promoted, which supports firmness of the skin, joint cartilage and connective tissue.
What sets Isotonix OPC-3 apart from other bioflavonoid products?
Isotonix OPC-3 offers scientifically supported OPCs, found to be the most potent antioxidants for human health. In addition to being powerful antioxidants, these individual OPCs have been shown to provide a myriad of specific health benefits. This science-driven selection of OPCs is unique to OPC-3, as is the Isotonix delivery system, which enables rapid and highly efficient absorption of the OPCs. The potent nutrients, in combination with the highly effective delivery system, makes OPC-3 the most powerful free radical scavenging product available.
Is Isotonix OPC-3 safe?
Yes. OPCs are among the most valuable constituents of a healthy human diet. OPCs have been researched and used for over 30 years throughout Europe. Extensive safety studies were conducted which revealed no evidence for human toxicity or allergic reactions. OPC-3 contains pure OPCs in combination with carefully balanced quantities of potassium and fructose/glucose, which set up the isotonic delivery system. OPC-3 is free of harmful chemicals, preservatives and alcohol. OPC-3 should be taken as directed.
How long does it take to benefit from Isotonix OPC-3?
OPC-3 not only provides the most potent OPCs available, the unique Isotonix delivery system ensures that the small intestine rapidly absorbs the OPCs, which are available in the blood stream within minutes. This is because the OPCs are delivered in liquid form. The liquid is isotonic, which means it duplicates the environment in our cells and blood stream regarding pH, electrolytes, etc. This enables the OPCs to enter the body easily and with a high level of bioavailability. Because of the rapid absorbability, the body should benefit from Isotonix OPC-3 almost immediately.
What is the advantage of taking Isotonix OPC-3 regularly?
Many effects of OPC-3 start to work after a single serving. Studies with human volunteers have found that the health benefits of OPCs may take a while to occur. This may be the case for health concerns resulting from everyday wear and tear, where time simply has taken its toll. Taking Isotonix OPC-3 daily enables the body to sustain a consistent antioxidant defense.
Why should everyone take Isotonix OPC-3?
Free radical damage and oxidative stress everyone is subject to. Free radicals develop as byproducts of physiological processes that occur within the body. This damage does not cause noticeable harm at first, yet may add up over the years. This process is largely responsible for the aging process. Free radicals have been linked directly to premature aging, poor circulation, poor heart health and poor immune health.
OPCs are the most powerful natural free radical neutralizers and you get the best of all OPCs by taking Isotonix OPC-3. Regular use every day is vital for keeping free radicals in check and a long, healthy life. Laboratory studies have shown that OPCs are more powerful antioxidants than vitamin C and vitamin E.
Can you take Isotonix OPC-3 in soda, juice, coffee, etc., rather than water?
It is possible but not recommended. This product should only be taken as directed. In order to keep the product in an isotonic form and to achieve the maximum delivery speed, it needs to be taken on an empty stomach with 2 oz. of water per capful. Mixing the products with anything else besides other Isotonix products and water slows down the delivery time and may affect the percentage of uptake.
I am healthy and athletic, why should I take Isotonix OPC-3?
Everyone is vulnerable to the aging process caused by continuous free radical damage. Athletes tend to be exposed to elevated levels of oxidative stress. Free radicals develop as byproducts during metabolism when calories are processed with oxygen. Athletes inhale 10 to 20 times more oxygen during physical activity over rest periods. The increase in activity creates additional free radicals. In fact, these free radicals are known to limit performance, as free radicals appear to take their toll on muscle tissue. Studies on recreational athletes have shown a 20 percent endurance increase with OPCs, as compared to a control group receiving a placebo. Another study has shown that athletes using OPCs suffered significantly less muscle cramping during and after performing. Isotonix OPC-3 helps to maintain healthy blood flow and this supports oxygen supply to muscles.*
Does OPC-3 have visible benefits?
As OPCs support collagen production in the skin, an increase of smoothness and elasticity is the natural result. Such an effect was objectively measured in women aged 40 years and older. Skin smoothness was increased after three months as measured by 3-dimensional topography. Likewise, increased skin elasticity was recorded with a special instrument known as a cutometer. It requires patience until skin cells have renewed significant amounts of collagen to show visible effects. It is essential to continuously take OPC-3 to keep skin cells at their peak vitality.
On a short-term basis, many people notice a fresher-looking skin complexion. This is a result of healthy blood microcirculation, which helps detoxify the skin and improves the nutrient supply. Regular use of OPC-3 helps defy photo-aging of the skin.*
Does OPC-3 have a rejuvenating effect?
The damage caused by free radicals adds up with time. A cause for more worry is the fact that your body's own mechanisms to keep free radicals in check decline with increasing age - when you need them the most. Suddenly, we find ourselves confronted with some typical age-related problems. Some cells of our body are more vulnerable to free radicals than others. OPC-3 has the ability to go in and do a knockout job, cleaning and scavenging the free radicals that feast on cellular energy, and take it away from vital processes.
What are the cardiovascular health benefits of OPCs?
Scientist Albert Szent-Gyorgyi, who received the Nobel Prize for the discovery of vitamin C, discovered OPCs. Szent-Györgyi found that OPCs work in a similar fashion. They strengthen the walls of arteries, veins and capillaries.
In the past 20 years scientists discovered that OPCs bear a lot more benefits for the cardiovascular system. Epidemiological studies have shown that regular intake of powerful OPC antioxidants supports a healthy cardiovascular system. OPCs appear to be particularly helpful in maintaining healthy cholesterol levels and healthy arteries.
Pycnogenol® in Isotonix OPC-3 plays a key role, as it stimulates an enzyme in the body to promote healthy nitric oxide (NO) levels. NO is a tiny molecule which serves as a key messenger molecule in the blood stream. It promotes relaxation of smooth muscle-surrounding arteries and supports normal artery diameter and blood flow. Healthy NO levels help maintain normal blood pressure. This benefit has been explicitly demonstrated with Pycnogenol in two clinical studies. NO also promotes healthy blood platelet activity thus preserving a normal, fluid environment. OPCs are especially helpful for smokers. OPC-3 packs a powerful punch when it comes to maintaining excellent cardiovascular health.
How can OPC-3 help my eyes?
Loss of eyesight is the disability people fear more than all others. Isotonix OPC-3 contains specific OPCs successfully tested for eye health.
Bilberry extract was shown to help maintain overall eye health in the vast majority of people in a study.
Pycnogenol has been shown to support healthy capillaries in the eye. Isotonix OPC-3 helps maintain visual health and supports visual acuity.*
Does OPC-3 have benefits specifically for women?
Some OPCs were shown in clinical trials to help women who suffer from mild pain and cramping during the menstrual period. When women were supplemented with OPCs, starting at least a week before their menstrual period, pain values were found to be significantly lowered.
What exactly is Pycnogenol?
Pycnogenol is the registered trademark of Horphag Research (UK) Ltd. for a standardized extract of bark of the French maritime pine tree. Pycnogenol is particularly renowned for its extensive clinical research with more than 120 studies published in peer-reviewed medical journals. The flavonoids in Pycnogenol not only act as powerful antioxidants, they also appear to aid in the generating of nitric oxide (NO). NO plays a key role in regulating cardiovascular health. Nitric oxide triggers the relaxation of arteries, restoring the normal diameter of blood vessels and supports healthy blood pressure and circulation. NO allows platelets to be less "sticky" allowing the blood to maintain a normal, fluid viscosity. Pycnogenol has been awarded various patents for its ability to influence platelet activity. In addition, in one of the few clinical trials of Pycnogenol, it dramatically inhibited smoking-induced platelet aggregation for longer than three days at a 200 mg dose.
How do I take OPC-3?
Each capful of Isotonix OPC-3 contains 125 milligrams of bioflavonoids, of which 75 milligrams are oligomeric proanthocyanidins in an isotonic-capable base. That means that the OPC-3 active ingredients will be delivered in the highest concentration to the small intestine, where most absorption of nutrients occurs.
To start using Isotonix OPC-3 for its benefit as an antioxidant and free radical scavenger, take two level capfuls for every 150 pounds of body weight for the first seven days. This is referred to as the saturation serving. Then, switch to a daily serving of one capful, per 150 lbs. of body weight, as a maintenance dose. For example, if you weigh 190 pounds, you would take three servings of Isotonix OPC-3 per day for seven days, and then switch to two servings per day for long-term health maintenance.
Isotonix OPC-3 has a pleasant natural grape flavor, is a vegetarian product and mixes instantly when added to water. This product should be taken on an empty stomach for the fastest, most effective delivery of the active ingredient. OPC-3 is a natural food supplement that should be taken for a lifetime.
What is the history of OPCs?
In 1534, French explorer Jacques Cartier was leading an expedition up the St. Lawrence River. Trapped by bad weather, Cartier and his crew were forced to survive on a ration of salted meat and biscuits. Cartier's crew began to suffer from severe deficiency of vitamin C and showed symptoms of scurvy. Many crewmembers died before the surviving members encountered a friendly Native American who saved most of their lives. He told them to make a tea from the bark and needles of the pine tree to cure their malady. They complied and, as a result, Cartier and many crewmembers survived.
Some 400 years later, Professor Jacques Masquelier of the University of Bordeaux, France, read a book by Cartier detailing their expedition. He concluded that pine bark not only contained some vitamin C, but obviously was a good source of bioflavonoids, whose effects are similar to those of vitamin C. Further studies and research revealed that the pine bark contained an array of proanthocyanidins complexes. These compounds were also found in a variety of plants, including grape seeds, cranberries, peanut skin, lemon tree bark and citrus rinds. Masquelier termed the active ingredients of the pine bark "pycnogenols", which today are referred to in the scientific community as oligomeric proanthocyanidins, or OPCs.
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Primary Benefits:
 |
| Isotonix OPC-3 |
° Combats free radicals
° Demonstrates anti-inflammatory activity
° Helps maintain healthy cholesterol levels
° Helps maintain healthy circulation by strengthening capillaries, arteries and veins
° Helps maintain joint flexibility
° Helps promote/support cardiovascular health
° Helps reduce mild menstrual cramping and abdominal pain
° Helps support visual health/visual acuity
° Potent free radical scavenger
° Promotes/Supports healthy blood vessel dilation
° Promotes/Supports healthy nitric oxide levels
° Supports a healthy complexion
° Supports healthy blood glucose levels
° Supports healthy platelet activity
° Supports healthy sperm quality
Key Ingredients:
Grape Seed Extract : 25 mg
Grape seed extract is typically extracted from the seeds of red grapes (instead of white), which have a high content of compounds known as oligomeric proanthocyanidins (OPCs). Grape seed extract is extremely rich in polyphenols, compounds with high antioxidant activity. Grape seed extract has been found to maintain healthy cholesterol levels.
Red Wine Extract: 25 mg
Red wine extract is a potent antioxidant. This extract is found in grape vines, roots, seeds and stalks, with the highest concentration in the skins. The antioxidant properties of red wine extract contribute to maintaining healthy circulation by strengthening capillaries, arteries and veins, and promoting overall cardiovascular health.
In the late 1990s, scientists took note of a phenomenon among the French. There were very low rates of cardiovascular problems in the provinces where residents consistently ate high fat foods and drank red wine. Scientists concluded that the protective properties of red wine have helped the French maintain cardiovascular health for years and subsequent scientific studies have further shown that the OPCs found in red wine are particularly beneficial for protecting the heart and blood vessels.
Pine Bark Extract (Pycnogenol®): 25 mg
Pycnogenol is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. This unspoiled and natural forest environment is the unique source of pine bark. Pycnogenol is one of the most researched ingredients in the natural product marketplace. Published findings have demonstrated Pycnogenol’s wide array of beneficial effects on the body. Pine bark extract is an all natural combination of procyanidins, bioflavonoids and organic acids.
The extract has four basic properties — it is a powerful antioxidant, acts as a natural anti-inflammatory, selectively binds to collagen and elastin, and aids in the production of endothelial nitric oxide, which helps to dilate blood vessels.
As one of the most potent natural scavenger of free radicals, Pycnogenol combats many aggressive free radicals before they cause oxidative stress to vital organs. Its super-antioxidant capabilities help support healthy blood platelet activity, support healthy blood glucose levels, reduce mild menstrual cramping and abdominal pain, maintain joint flexibility, promote cardiovascular health, promote healthy sperm quality, maintain healthy cholesterol levels and support a healthy complexion.
Bilberry Extract : 25 mg
Bilberry extract is derived from the leaves and berry-like fruit of a common European shrub closely related to the blueberry. Extracts of the ripe berry are known to contain flavonoid pigments known as anthocyanins, which are powerful antioxidants. Scientific studies confirm that bilberry extract supports healthy vision and venous circulation. Bilberry extract helps maintain healthy circulation by strengthening capillaries, arteries and veins.
Citrus Extract (Bioflavonoids): 25 mg
Bioflavonoids are antioxidants found in certain plants that act as light filters, which protect delicate DNA chains and other important macromolecules by absorbing ultraviolet radiation. They have been found to promote cardiovascular health, help maintain healthy circulation by strengthening capillaries, arteries and veins, and demonstrate anti-inflammatory activity.
Grape Seed Extract for Blood Pressure?
Study: Grape Seed Extract May Help Tame Prehypertension By Miranda Hitti
WebMD Medical News
Reviewed By Louise Chang, MD
on Monday, March 27, 2006
SOURCES: American Chemical Society National Meeting & Exposition,Atlanta, March 26-30, 2006. Tissa Kappagoda, MD, PhD, professor of internal medicine (cardiovascular medicine), University of California, Davis. News release, University of California, Davis. News release, American Chemical Society.
Grape and Salicin-Rich Extracts for Cardiovascular Disease Prevention
HerbalGram. 2004;63:25 © American Botanical Council
Supplement Speeds Wound Healing
Antioxidant Cocktail Contains 4 Skin-Friendly Substances
By Sid Kirchheimer
WebMD Medical News
Reviewed By Brunilda Nazario, MD
on Thursday, July 08, 2004
The effect of polyphenolic extract from pine bark, Pycnogenol on the level of glutathione in children suffering from attention deficit hyperactivity disorder (ADHD). Redox Rep. 2006;11(4):163-72.
Nonalcoholic Red Wine Extract and Quercetin Inhibit LDL Oxidation without Affecting Plasma Antioxidant Vitamin and Carotenoid Concentrations
(Clinical Chemistry. 2000;46:1162-1170.)
© 2000 American Association for Clinical Chemistry, Inc.
Pycnogenol reduces osteoarthritis pain, study
Scientific Studies:
o Bayeta, E., et al. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Research 20: 249-259, 2000.
o Blazsó, G., et al. Anti-inflammatory and superoxide radical scavenging activities of a procyanidins containing extract from the bark of Pinus pinaster Sol. and its fractions. Pharm Pharmacol Lett 3: 217-20, 1994.
o Cho, K., et al. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interlukin-1 production in lipopolysaccharide-stimulated RAW 264. 7. Toxicology and Applied Pharmacology 168: 64-71, 2000.
o Cho, K., et al. Inhibition mechanisms of bioflavonoids extracted from the bark of Pinus maritima on the expression of proinflammatory cytokines. Annals of the NY Academy of Sciences 928: 141-156, 2001.
o Devaraj, S., et al. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids 37:931-4, 2002.
o Fine, AM, Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000.
o Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
o Frankel, E., et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341: 454-7, 1993.
o Freedman, J., et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103:2792-8, 2001.
o Frémont, L. Biological effects of resveratrol. Life Sciences 66: 663-673, 2000.
o Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
o Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001. HHHh
o Kohama, T., et al. The treatment of gynecological disorders with Pycnogenol®. European Bulletin of Drug Research 7: 30-32, 1999.
o Kohama, T., et al. Analgesic efficacy of French maritime pine bark extract in dysmenorrhea. Journal of Reproductive Medicine 49: 828-32, 2004.
o Liu, X., et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 75:2505-13, 2004.
o Liu, X., et al. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients. Diabetes Care 27: 839, 2004.
o Manna, S., et al. Resveratrol suppresses TNF-Induced activation of nuclear transcription factors NF-kB, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. The Journal of Immunology 164: 6509-19, 2000.
o Maritim, A., et al. Effects of pycnogenol treatment on oxidative stress in streptozotocin-induced diabetic rats. J Biochem Mol Toxicol 17:193-9, 2003.
o Miyagi, Y., et al. Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice. Am J Cardiol 0:1627-31, 1997.
o Monograph. Vaccinium myrtillus (bilberry). Altern Med Rev 6:500-4, 2001.
o Murias M., et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 12: 5571-8, 2004.
o Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23: 385-89, 1998.
o Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol. Free Radic Biol Med 27:704-24, 1999. Review.
o Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
o Rohdewald, P. Pycnogenol®. In "Flavonoids in Health and Disease". Ed. Catherine Rice-Evans and Lester Packer. New York: Marcel Dekker, Inc., 1998. 405-19.
o Roseff, S., et al. Improvement in sperm quality and function with French maritime pine tree bark extract. Journal Reproductive Medicine 47: 821-4, 2002.
o Roseff, S., et al. Improvement of sperm quality by Pycnogenol®. European Bulletin of Drug Research 7: 33-6, 1999.
o Saito, M., et al. Antiulcer activity of grape seed extract and procyanidins. J Agric Food Chem 46: 1460-4, 1998.
o Schönlau, F., et al. Pycnogenol® for diabetic retinopathy. International Ophthalmology 24: 161-171, 2002.
o Schönlau, F., et al. The cosmeceutical Pycnogenol®. J Appl Cosmetology 20: 241-6, 2002.
o Segger, D. and Schönlau, F. Supplementation with Evelle® improves skin smoothness and elasticity in a double blind, placebo-controlled study with 62 women. Journal of Dermatological Treatment 15:222-26, 2004.
o Shi, J., et al. Polyphenolics in grape seeds-biochemistry and functionality. J Med Food 6:291-9, 2003. Review.
o Sharma, S., et al. Pycnogenol® inhibits the release of histamine from mast cells. Phytotherapy Research 17: 66-69, 2003.
o Spadea, L., et al. Treatment of vascular retinopathies with Pycnogenol®. Phytotherapy Research 15: 219-23, 2001.
o Stein, J., et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050-5, 1999.
o Takada, Y., et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 23: 9247-58, 2004.
o Ueda, T., et al. Preventative effect of natural and synthetic antioxidants on lipid peroxidation in the mammalian eye. Ophthalmic Res 28: 184-92, 1996.
o Wallerath, T., et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652-8, 2002.
o Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
o Wei, Z., et al. Pycnogenol enhances endothelial cell antioxidant defense. Redox Report 3: 219-24, 1997.
o Yamakoshi, J., et al. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 142:139-149, 1999.
o Ames, BN, et al. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 90:7915-7922, 1993.
o Bagchi, D, et al. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol Pharmacol 95:179-89, 1997.
o Bagchi, D, et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148: 187-97, 2000.
o Bagchi, D, et al. Cellular protection with proanthocyanidins derived from grape seed. Ann NY Acad Sci 957:260-70, 2002.
o Cao G, Alessio H, Cultler R. Oxygen-radical absorbance capacity assay for antioxidants. Fre Rad Biol & Med 14:301-11, 1993.
o Drew B, Leeuwenburgh C. Aging and the role of reactive nitrogen species. Ann NY Acad Sci 959:66-81, 2002.
o Gibson, L, et al. Effectiveness of cranberry juice in preventing urinary tract infections in long-term care facility patients. J Naturopathic Med 2:45-47, 1991.
o Graham DY, Smith JL, Bouvet, AA. What happens to tablets in the stomach. J Pharm Sci 79:420-24, 1990.
o Havsteen B. Flavonoids, a class of natural products of high pharmacological potency. Biochem Pharm 32:1141-48, 1983.
o Halpern, MJ, et al. Red wine polyphenols and inhibition of platelet aggregation: possible mechanisms, and potential use in health promotion and disease prevention. J Int Med Res 26:171-80, 1998.
o Joseph JA, Shukitt-Hale B, Denisova NA, Bielinksi D, Martin A, McEwen JJ, Bickford PC. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neuroscience 19: 8114-21, 1999.
o Kay CD, Holub BJ. The effect of wild blueberry (Vaccinium angustifolium) on post-prandial serum antioxidant status in human subjects. Br J Nutr 88: 389-98, 2002.
o Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol 23:21-48, 1993.
o Koch R. Comparative study of Venostatin and Pycnogenol in chronic venous insufficiency. Phytother Res 16:S1-5, 2002.
o Koparker AD, Augsburger LL, Shangraw RF. Intrinsic dissolution rates of tablet fillers and binders and their influence on the dissolution of drugs from tablet formulations. Pharm Res 7:80-85, 1990.
o Mazza G, Kay CD, Cottrell T, Holub BJ. Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects. J Agric Food Chem 50:7731-37, 2002.
o Nesaretnam K, et al. Effect of tocotrienols on the growth of a human breast cancer cell line in culture. Lipids 30:1139-43, 1995.
o Ofek I, Goldhar J, Zafriri D, Lis H, Sharon N. Anti-Escherichia coli adhesion activity of cranberry and blueberry juices. New England J Med 324:1599, 1991.
o Qureshi, A, et al. Response of hypercholesterolemic subjects to administration of tocotrienols. Lipids 30:1171-77, 1995.
o Rimbach G, Virgili F, Park YC, Packer L. Effect of procyanidins from Pinus maritime on glutathione levels in endothelial cells challenged by 3-morpholinosydnonimine or activated macrophages. Redox Rep 4:171-77, 1999.
o Sobota AE. Inhibition of bacterial adherence by cranberry juice: potential use for the treatment of urinary tract infactions. J Urology 131:1013-1016, 1984.
o Soloway MS, Smith RA. J Am Med Assoc 260:1465, 1988.
o Tomco, A, et al. Antioxidant effects of tocotrienol in patients with hyperlipidemia and carotid stenosis. Lipids 30: 1179-83, 1995.
o Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51:502-9, 2003.
What Makes This Product Unique?
A free radical is an atomic structure with an unpaired electron in its outermost shell. These unpaired electrons tend to be highly reactive, resulting in chemical reactions such as oxidation. Because they have one or more unpaired electrons, free radicals are highly unstable. They scavenge the body to grab or donate electrons, causing damage to cells, proteins and DNA. Free radicals are naturally occurring; however, air pollution, stress, smoking, heavy exercising and aging all contribute to the creation of harmful free radicals. Free radicals can cause oxidative damage to the body, potentially leading to serious health problems. Normally the body is able to protect itself from the damaging effects of free radicals, but if antioxidants are unavailable, or if free radical production becomes excessive, damage can occur.
Antioxidants are natural cell protectors, neutralizing free radicals by pairing an electron to the outermost shell of radical oxygen molecules, rendering them harmless. Antioxidants are nutrients such as vitamins and minerals, and enzymes that are capable of counteracting the damaging, but normal, effects of the physiological process of oxidation in bodily tissues. Antioxidants work in two ways, chain breaking and prevention. A chain-breaking antioxidant such as vitamins A, C and E, stabilize free radicals or cause them to decay into harmless atomic structures. A preventative antioxidant prevents the oxidation process by scavenging free radicals.
Isotonix OPC-3® is an isotonic-capable food supplement that is made from a combination of bilberry, grape seed, red wine, pine bark extracts and citrus extract bioflavonoids, all found to be potent antioxidants. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to the human body. Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. Isotonix OPC-3 contains the only isotonic form of Pycnogenol® in the world. Pycnogenol is a natural plant extract from the bark of the French maritime pine tree, and the most clinically researched and potent bioflavonoid.
Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state.
Isotonix® dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.
Frequently Asked Questions:
What is Isotonix OPC-3?
Isotonix OPC-3 is a dietary supplement that bears some of the most powerful bioflavonoids currently known to research scientists. These bioflavonoids are scientifically termed oligomeric proanthocyanidins, commonly abbreviated OPCs. The purest and best-researched OPCs chosen for OPC-3 are prepared from grape seed, red wine, bilberries, Pycnogenol from pine bark and citrus fruit. This combination of potent OPCs is unique to OPC-3, as is the Isotonix delivery system, which enables rapid and highly efficient absorption of the OPCs. Isotonix OPC-3 has been shown to provide a variety of health benefits including but not limited to combating free radicals, demonstrating anti-inflammatory activity, helping maintain healthy cholesterol levels, helping maintain healthy circulation by strengthening capillaries, arteries and veins, helping maintain joint flexibility, helping promote/support cardiovascular health, helping reduce mild menstrual cramping and abdominal pain, helping support visual health/visual acuity, scavenging free radicals, promoting/supporting healthy blood vessel dilation, promoting/supporting healthy nitric oxide levels, supporting a healthy complexion, supporting healthy blood glucose levels, supporting healthy platelet activity and supporting healthy sperm quality.
What is a bioflavonoid?
Bioflavonoids are complex organic plant compounds. Plants and fruits differ in colors based on the specific bioflavonoids they contain. An increasing number of clinical studies have shown how bioflavonoids support health. Bioflavonoids found in OPCs play a key role in cardiovascular health and maintaining vascular integrity. Bioflavonoids have been shown to demonstrate support for healthy circulation and cell vitality. Normal collagen renewal is promoted, which supports firmness of the skin, joint cartilage and connective tissue.
What sets Isotonix OPC-3 apart from other bioflavonoid products?
Isotonix OPC-3 offers scientifically supported OPCs, found to be the most potent antioxidants for human health. In addition to being powerful antioxidants, these individual OPCs have been shown to provide a myriad of specific health benefits. This science-driven selection of OPCs is unique to OPC-3, as is the Isotonix delivery system, which enables rapid and highly efficient absorption of the OPCs. The potent nutrients, in combination with the highly effective delivery system, makes OPC-3 the most powerful free radical scavenging product available.
Is Isotonix OPC-3 safe?
Yes. OPCs are among the most valuable constituents of a healthy human diet. OPCs have been researched and used for over 30 years throughout Europe. Extensive safety studies were conducted which revealed no evidence for human toxicity or allergic reactions. OPC-3 contains pure OPCs in combination with carefully balanced quantities of potassium and fructose/glucose, which set up the isotonic delivery system. OPC-3 is free of harmful chemicals, preservatives and alcohol. OPC-3 should be taken as directed.
How long does it take to benefit from Isotonix OPC-3?
OPC-3 not only provides the most potent OPCs available, the unique Isotonix delivery system ensures that the small intestine rapidly absorbs the OPCs, which are available in the blood stream within minutes. This is because the OPCs are delivered in liquid form. The liquid is isotonic, which means it duplicates the environment in our cells and blood stream regarding pH, electrolytes, etc. This enables the OPCs to enter the body easily and with a high level of bioavailability. Because of the rapid absorbability, the body should benefit from Isotonix OPC-3 almost immediately.
What is the advantage of taking Isotonix OPC-3 regularly?
Many effects of OPC-3 start to work after a single serving. Studies with human volunteers have found that the health benefits of OPCs may take a while to occur. This may be the case for health concerns resulting from everyday wear and tear, where time simply has taken its toll. Taking Isotonix OPC-3 daily enables the body to sustain a consistent antioxidant defense.
Why should everyone take Isotonix OPC-3?
Free radical damage and oxidative stress everyone is subject to. Free radicals develop as byproducts of physiological processes that occur within the body. This damage does not cause noticeable harm at first, yet may add up over the years. This process is largely responsible for the aging process. Free radicals have been linked directly to premature aging, poor circulation, poor heart health and poor immune health.
OPCs are the most powerful natural free radical neutralizers and you get the best of all OPCs by taking Isotonix OPC-3. Regular use every day is vital for keeping free radicals in check and a long, healthy life. Laboratory studies have shown that OPCs are more powerful antioxidants than vitamin C and vitamin E.
Can you take Isotonix OPC-3 in soda, juice, coffee, etc., rather than water?
It is possible but not recommended. This product should only be taken as directed. In order to keep the product in an isotonic form and to achieve the maximum delivery speed, it needs to be taken on an empty stomach with 2 oz. of water per capful. Mixing the products with anything else besides other Isotonix products and water slows down the delivery time and may affect the percentage of uptake.
I am healthy and athletic, why should I take Isotonix OPC-3?
Everyone is vulnerable to the aging process caused by continuous free radical damage. Athletes tend to be exposed to elevated levels of oxidative stress. Free radicals develop as byproducts during metabolism when calories are processed with oxygen. Athletes inhale 10 to 20 times more oxygen during physical activity over rest periods. The increase in activity creates additional free radicals. In fact, these free radicals are known to limit performance, as free radicals appear to take their toll on muscle tissue. Studies on recreational athletes have shown a 20 percent endurance increase with OPCs, as compared to a control group receiving a placebo. Another study has shown that athletes using OPCs suffered significantly less muscle cramping during and after performing. Isotonix OPC-3 helps to maintain healthy blood flow and this supports oxygen supply to muscles.*
Does OPC-3 have visible benefits?
As OPCs support collagen production in the skin, an increase of smoothness and elasticity is the natural result. Such an effect was objectively measured in women aged 40 years and older. Skin smoothness was increased after three months as measured by 3-dimensional topography. Likewise, increased skin elasticity was recorded with a special instrument known as a cutometer. It requires patience until skin cells have renewed significant amounts of collagen to show visible effects. It is essential to continuously take OPC-3 to keep skin cells at their peak vitality.
On a short-term basis, many people notice a fresher-looking skin complexion. This is a result of healthy blood microcirculation, which helps detoxify the skin and improves the nutrient supply. Regular use of OPC-3 helps defy photo-aging of the skin.*
Does OPC-3 have a rejuvenating effect?
The damage caused by free radicals adds up with time. A cause for more worry is the fact that your body's own mechanisms to keep free radicals in check decline with increasing age - when you need them the most. Suddenly, we find ourselves confronted with some typical age-related problems. Some cells of our body are more vulnerable to free radicals than others. OPC-3 has the ability to go in and do a knockout job, cleaning and scavenging the free radicals that feast on cellular energy, and take it away from vital processes.
What are the cardiovascular health benefits of OPCs?
Scientist Albert Szent-Gyorgyi, who received the Nobel Prize for the discovery of vitamin C, discovered OPCs. Szent-Györgyi found that OPCs work in a similar fashion. They strengthen the walls of arteries, veins and capillaries.
In the past 20 years scientists discovered that OPCs bear a lot more benefits for the cardiovascular system. Epidemiological studies have shown that regular intake of powerful OPC antioxidants supports a healthy cardiovascular system. OPCs appear to be particularly helpful in maintaining healthy cholesterol levels and healthy arteries.
Pycnogenol® in Isotonix OPC-3 plays a key role, as it stimulates an enzyme in the body to promote healthy nitric oxide (NO) levels. NO is a tiny molecule which serves as a key messenger molecule in the blood stream. It promotes relaxation of smooth muscle-surrounding arteries and supports normal artery diameter and blood flow. Healthy NO levels help maintain normal blood pressure. This benefit has been explicitly demonstrated with Pycnogenol in two clinical studies. NO also promotes healthy blood platelet activity thus preserving a normal, fluid environment. OPCs are especially helpful for smokers. OPC-3 packs a powerful punch when it comes to maintaining excellent cardiovascular health.
How can OPC-3 help my eyes?
Loss of eyesight is the disability people fear more than all others. Isotonix OPC-3 contains specific OPCs successfully tested for eye health.
Bilberry extract was shown to help maintain overall eye health in the vast majority of people in a study.
Pycnogenol has been shown to support healthy capillaries in the eye. Isotonix OPC-3 helps maintain visual health and supports visual acuity.*
Does OPC-3 have benefits specifically for women?
Some OPCs were shown in clinical trials to help women who suffer from mild pain and cramping during the menstrual period. When women were supplemented with OPCs, starting at least a week before their menstrual period, pain values were found to be significantly lowered.
What exactly is Pycnogenol?
Pycnogenol is the registered trademark of Horphag Research (UK) Ltd. for a standardized extract of bark of the French maritime pine tree. Pycnogenol is particularly renowned for its extensive clinical research with more than 120 studies published in peer-reviewed medical journals. The flavonoids in Pycnogenol not only act as powerful antioxidants, they also appear to aid in the generating of nitric oxide (NO). NO plays a key role in regulating cardiovascular health. Nitric oxide triggers the relaxation of arteries, restoring the normal diameter of blood vessels and supports healthy blood pressure and circulation. NO allows platelets to be less "sticky" allowing the blood to maintain a normal, fluid viscosity. Pycnogenol has been awarded various patents for its ability to influence platelet activity. In addition, in one of the few clinical trials of Pycnogenol, it dramatically inhibited smoking-induced platelet aggregation for longer than three days at a 200 mg dose.
How do I take OPC-3?
Each capful of Isotonix OPC-3 contains 125 milligrams of bioflavonoids, of which 75 milligrams are oligomeric proanthocyanidins in an isotonic-capable base. That means that the OPC-3 active ingredients will be delivered in the highest concentration to the small intestine, where most absorption of nutrients occurs.
To start using Isotonix OPC-3 for its benefit as an antioxidant and free radical scavenger, take two level capfuls for every 150 pounds of body weight for the first seven days. This is referred to as the saturation serving. Then, switch to a daily serving of one capful, per 150 lbs. of body weight, as a maintenance dose. For example, if you weigh 190 pounds, you would take three servings of Isotonix OPC-3 per day for seven days, and then switch to two servings per day for long-term health maintenance.
Isotonix OPC-3 has a pleasant natural grape flavor, is a vegetarian product and mixes instantly when added to water. This product should be taken on an empty stomach for the fastest, most effective delivery of the active ingredient. OPC-3 is a natural food supplement that should be taken for a lifetime.
What is the history of OPCs?
In 1534, French explorer Jacques Cartier was leading an expedition up the St. Lawrence River. Trapped by bad weather, Cartier and his crew were forced to survive on a ration of salted meat and biscuits. Cartier's crew began to suffer from severe deficiency of vitamin C and showed symptoms of scurvy. Many crewmembers died before the surviving members encountered a friendly Native American who saved most of their lives. He told them to make a tea from the bark and needles of the pine tree to cure their malady. They complied and, as a result, Cartier and many crewmembers survived.
Some 400 years later, Professor Jacques Masquelier of the University of Bordeaux, France, read a book by Cartier detailing their expedition. He concluded that pine bark not only contained some vitamin C, but obviously was a good source of bioflavonoids, whose effects are similar to those of vitamin C. Further studies and research revealed that the pine bark contained an array of proanthocyanidins complexes. These compounds were also found in a variety of plants, including grape seeds, cranberries, peanut skin, lemon tree bark and citrus rinds. Masquelier termed the active ingredients of the pine bark "pycnogenols", which today are referred to in the scientific community as oligomeric proanthocyanidins, or OPCs.
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OPC-3 Pet Health.
Benefits:
° Combats free radicals
° Helps maintain healthy cholesterol levels
° Helps maintain healthy circulation
° Helps maintain joint flexibility
° Helps promote/support cardiovascular health
° Helps support visual health/visual acuity
° Potent free radical scavenger
° Promotes/Supports healthy blood vessel dilation
° Promotes/Supports healthy nitric oxide levels
° Supports healthy blood glucose levels
° Supports healthy platelet activity
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view product demo print this page e-mail this page to a friend Key Ingredients:
Grape Seed Extract
Grape seed extract helps protect cells from free radical damage. Rich in polyphenols, beneficial compounds that have been shown to support normal circulation, grape seed extract can help maintain a healthy circulatory system.
Red Wine Extract
Red wine extract is a potent antioxidant that contains beneficial amounts of resveratrol. Resveratrol can promote normal blood platelet activity and it is believed that it is partially responsible for the cardiovascular health benefits associated with red wine.
Pine Bark Extract
Another strong antioxidant, pine bark extract has been shown to support normal circulation, the immune system and the strength of blood vessel walls.
Bilberry Extract
Bilberry extract is beneficial in promoting strong red blood cells and capillaries, specifically around the eyes and in the retina. Bilberry extract supports the capillaries in the body to help maintain optimal peripheral circulation.
Citrus Bioflavonoids
Citrus bioflavonoids are natural substances found in fruits and vegetables, nuts, and some tree barks. They counter the effects of free radical damage and also promote respiratory health.
Glucosamine
Glucosamine is an aminopolysaccharide (a combination of the amino acid - glutamine and a sugar - glucose). Glucosamine is concentrated in joint cartilage where it is incorporated in longer chains known as glycosaminoglycans and finally into very large structures known as proteoglycans. Glucosamine is naturally produced by the body, and is a key component of cartilage. Glucosamine promotes normal joint function and the normal production of synovial fluid, which lubricates the joints and promotes the normal regeneration of cartilage.
There are numerous European studies showing a clear benefit of glucosamine supplements for promoting joint health. Glucosamine may also support chondrocytes (cartilage cells) in the normal production of healthy new cartilage matrix (both collagen and proteoglycans).
Optimization by Blending
It has been suggested that several antioxidants blended together in moderate amounts may be more effective than high levels of one antioxidant. The blend of antioxidants in PetHealth™ OPC Formula Powder includes grape seed extract, red wine extract, pine bark extract, bilberry extract and citrus bioflavonoids. These antioxidants contain oligomeric proanthocyanidins, or OPCs. Much the same way antioxidants can help optimize a person's health, they can also be beneficial to our dogs and cats. Antioxidants help fight the damage caused by free radicals. They can also help support immune responses and support normal vaccine recognition in dogs and cats. Young animals can benefit tremendously from antioxidants. Antioxidants can help maintain optimum health in your animal's gastrointestinal and cardiovascular systems, liver, kidneys, eyes and immune system. Another important role of pet antioxidants is their ability to support immune-cell function for dogs and cats in their senior years.
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view product demo print this page e-mail this page to a friend
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view product demo print this page e-mail this page to a friend What Makes This Product Unique?
A free radical is an atomic structure with an unpaired electron in its outermost shell. These unpaired electrons tend to be highly reactive, resulting in chemical reactions such as oxidation. Because they have one or more unpaired electrons, free radicals are highly unstable. They scavenge the body to grab or donate electrons, causing damage to cells, proteins and DNA. Free radicals are naturally occurring; however, air pollution, stress, cigarette smoke and heavy exercising all contribute to the creation of harmful free radicals. Free radicals can cause oxidative stress. Normally the animal’s body is able to protect itself from the damaging effects of free radicals, but if antioxidants are unavailable, or free radical production becomes excessive, oxidative stress can occur.
Antioxidants are natural cell protectors, neutralizing free radicals by pairing an electron to the outermost shell of radical oxygen molecules, rendering them harmless. Antioxidants are nutrients such as vitamins, minerals and enzymes that are capable of counteracting the damaging, but normal, effects of the physiological process of oxidation in bodily tissues. Antioxidants work in two ways, chain breaking and prevention. A chain-breaking antioxidant such as vitamins A, C and E, stabilize free radicals or cause them to decay into harmless atomic structures. A preventative antioxidant prevents the oxidation process by scavenging free radicals.
PetHealth™ OPC is a food supplement made from a combination of bilberry, grape seed, red wine, pine bark extracts, citrus extract bioflavonoids, and glucosamine, designed to promote healthy joints and provide a strong antioxidant defense. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to your pet’s body. Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. PetHealth OPC Formula with Glucosamine offers a unique, great-tasting powder that is sprinkled over your pet’s regular food. It represents the latest technology available today in naturally based pet food supplements. PetHealth OPC Formula is available in a tasty beef flavor that your pets will love - and youll love knowing that youre doing all you can to help your pets stay healthy and live long, healthy lives.
Pets face many of the same issues as humans. Many pet foods are over processed and have little nutritive value. Dogs and cats breathe in the same pollution as we do, inhaling harmful free radicals. Potent antioxidants like OPCs help to strengthen your pet’s free radical defenses. Antioxidants promote cardiovascular health, support healthy visual acuity, promote healthy blood vessel dilation and promote healthy platelet activity.
Your Pets and Joint Health
As pets become older, antioxidants become even more important in the fight against free radicals and their associated effects on cells in joints and other tissues. All animals are at risk for declining joint health. Many factors can affect joint health and the integrity of cartilage, including diet, genetic make-up and activity levels. The cold wintery months can also contribute to a decline in joint comfort. Each animals genetic code, for example, can influence the thickness and durability of its cartilage and its overall joint health. Proper nutrition, especially antioxidant supplementation, is critical in maintaining healthy joints. Glucosamine has been shown to promote the retention and normal regeneration of cartilage, support normal movement and flexibility of joints and promote joint comfort.
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view product demo print this page e-mail this page to a friend Frequently Asked Questions
What Are OPCs?
OPCs, or oligomeric proanthocyanidins, can help reduce free radical damage, support the strength and normal repair of connective tissue, and can support proper enzyme activity. OPCs can also help maintain normal histamine levels. Not limited to being just strong antioxidants, OPCs are also crucial in their role in supporting the circulatory system.
What Are Antioxidants, and Why Should I Give Them To My Pets?
Antioxidants are naturally occurring nutrients that help maintain optimum health by protecting against free radicals. Antioxidants are found in the body naturally as well as in many plants. Even cells that function normally generate large amounts of oxygen free radicals. Free radicals have an unpaired electron, making many of them reactive and destructive. When free radicals roam freely throughout the body unregulated by antioxidants, they can attack various healthy cell structures, including cell membranes, proteins, RNA and DNA.
Certain factors in everyday life encourage an increase in the formation of free radicals for humans and pets alike. These factors include the air we breathe, the water we drink, and the food we eat. Each one of these necessities can contain harmful reactants. We need a "neutralizer" in our body to rid our system of these harmful reactants and a strong and effective antioxidant is the best way to fight free radicals.
It is becoming increasingly apparent to veterinarians that antioxidant supplementation could very well provide optimal health support for dogs and cats in a manner similar to that experienced by humans. Both pets and their owners could benefit from a "neutralizer" operating in their systems that fight free radicals. A strong antioxidant is the best way to fight free radicals.
What is a bioflavonoid?
Bioflavonoids are complex organic plant compounds. Plants and fruits differ in colors based on the specific bioflavonoids they contain. An increasing number of clinical studies have shown how bioflavonoids support health. Bioflavonoids and OPCs play a key role in supporting cardiovascular health and maintaining vascular integrity. Bioflavonoids have been shown to support healthy circulation and cell vitality. Normal collagen renewal is promoted, which supports firmness of the skin, joint cartilage and connective tissue.
What is the history of OPCs?
In 1534, French explorer Jacques Cartier was leading an expedition up the St. Lawrence River. Trapped by bad weather, Cartier and his crew were forced to survive on a ration of salted meat and biscuits. Cartier's crew began to suffer from severe deficiency of vitamin C and showed symptoms of scurvy. Many crewmembers died before the surviving members encountered a friendly Native American who saved most of their lives. He told them to make a tea from the bark and needles of the pine tree to cure their malady. They complied and, as a result, Cartier and many crewmembers survived.
Some 400 years later, Professor Jacques Masquelier of the University of Bordeaux, France, read a book by Cartier detailing their expedition. He concluded that pine bark not only contained some vitamin C, but obviously was a good source of bioflavonoids, whose effects are similar to those of vitamin C. Further studies and research revealed that the pine bark contained an array of proanthocyanidins complexes. These compounds were also found in a variety of plants, including grape seeds, cranberries, peanut skin, lemon tree bark and citrus rinds. Masquelier termed the active ingredients of the pine bark "pycnogenols", which today are referred to in the scientific community as oligomeric proanthocyanidins, or OPCs.
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view product demo print this page e-mail this page to a friend Click here to view product label
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view product demo print this page e-mail this page to a friend Benefits:
° Combats free radicals
° Helps maintain healthy cholesterol levels
° Helps maintain healthy circulation
° Helps maintain joint flexibility
° Helps promote/support cardiovascular health
° Helps support visual health/visual acuity
° Potent free radical scavenger
° Promotes/Supports healthy blood vessel dilation
° Promotes/Supports healthy nitric oxide levels
° Supports healthy blood glucose levels
° Supports healthy platelet activity
Key Ingredients:
Grape Seed Extract
Grape seed extract helps protect cells from free radical damage. Rich in polyphenols, beneficial compounds that have been shown to support normal circulation, grape seed extract can help maintain a healthy circulatory system.
Red Wine Extract
Red wine extract is a potent antioxidant that contains beneficial amounts of resveratrol. Resveratrol can promote normal blood platelet activity and it is believed that it is partially responsible for the cardiovascular health benefits associated with red wine.
Pine Bark Extract
Another strong antioxidant, pine bark extract has been shown to support normal circulation, the immune system and the strength of blood vessel walls.
Bilberry Extract
Bilberry extract is beneficial in promoting strong red blood cells and capillaries, specifically around the eyes and in the retina. Bilberry extract supports the capillaries in the body to help maintain optimal peripheral circulation.
Citrus Bioflavonoids
Citrus bioflavonoids are natural substances found in fruits and vegetables, nuts, and some tree barks. They counter the effects of free radical damage and also promote respiratory health.
Glucosamine
Glucosamine is an aminopolysaccharide (a combination of the amino acid - glutamine and a sugar - glucose). Glucosamine is concentrated in joint cartilage where it is incorporated in longer chains known as glycosaminoglycans and finally into very large structures known as proteoglycans. Glucosamine is naturally produced by the body, and is a key component of cartilage. Glucosamine promotes normal joint function and the normal production of synovial fluid, which lubricates the joints and promotes the normal regeneration of cartilage.
There are numerous European studies showing a clear benefit of glucosamine supplements for promoting joint health. Glucosamine may also support chondrocytes (cartilage cells) in the normal production of healthy new cartilage matrix (both collagen and proteoglycans).
Optimization by Blending
It has been suggested that several antioxidants blended together in moderate amounts may be more effective than high levels of one antioxidant. The blend of antioxidants in PetHealth™ OPC Formula Powder includes grape seed extract, red wine extract, pine bark extract, bilberry extract and citrus bioflavonoids. These antioxidants contain oligomeric proanthocyanidins, or OPCs. Much the same way antioxidants can help optimize a person's health, they can also be beneficial to our dogs and cats. Antioxidants help fight the damage caused by free radicals. They can also help support immune responses and support normal vaccine recognition in dogs and cats. Young animals can benefit tremendously from antioxidants. Antioxidants can help maintain optimum health in your animal's gastrointestinal and cardiovascular systems, liver, kidneys, eyes and immune system. Another important role of pet antioxidants is their ability to support immune-cell function for dogs and cats in their senior years.
What Makes This Product Unique?
A free radical is an atomic structure with an unpaired electron in its outermost shell. These unpaired electrons tend to be highly reactive, resulting in chemical reactions such as oxidation. Because they have one or more unpaired electrons, free radicals are highly unstable. They scavenge the body to grab or donate electrons, causing damage to cells, proteins and DNA. Free radicals are naturally occurring; however, air pollution, stress, cigarette smoke and heavy exercising all contribute to the creation of harmful free radicals. Free radicals can cause oxidative stress. Normally the animal’s body is able to protect itself from the damaging effects of free radicals, but if antioxidants are unavailable, or free radical production becomes excessive, oxidative stress can occur.
Antioxidants are natural cell protectors, neutralizing free radicals by pairing an electron to the outermost shell of radical oxygen molecules, rendering them harmless. Antioxidants are nutrients such as vitamins, minerals and enzymes that are capable of counteracting the damaging, but normal, effects of the physiological process of oxidation in bodily tissues. Antioxidants work in two ways, chain breaking and prevention. A chain-breaking antioxidant such as vitamins A, C and E, stabilize free radicals or cause them to decay into harmless atomic structures. A preventative antioxidant prevents the oxidation process by scavenging free radicals.
PetHealth™ OPC is a food supplement made from a combination of bilberry, grape seed, red wine, pine bark extracts, citrus extract bioflavonoids, and glucosamine, designed to promote healthy joints and provide a strong antioxidant defense. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to your pet’s body. Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. PetHealth OPC Formula with Glucosamine offers a unique, great-tasting powder that is sprinkled over your pet’s regular food. It represents the latest technology available today in naturally based pet food supplements. PetHealth OPC Formula is available in a tasty beef flavor that your pets will love - and youll love knowing that youre doing all you can to help your pets stay healthy and live long, healthy lives.
Pets face many of the same issues as humans. Many pet foods are over processed and have little nutritive value. Dogs and cats breathe in the same pollution as we do, inhaling harmful free radicals. Potent antioxidants like OPCs help to strengthen your pet’s free radical defenses. Antioxidants promote cardiovascular health, support healthy visual acuity, promote healthy blood vessel dilation and promote healthy platelet activity.
Your Pets and Joint Health
As pets become older, antioxidants become even more important in the fight against free radicals and their associated effects on cells in joints and other tissues. All animals are at risk for declining joint health. Many factors can affect joint health and the integrity of cartilage, including diet, genetic make-up and activity levels. The cold wintery months can also contribute to a decline in joint comfort. Each animals genetic code, for example, can influence the thickness and durability of its cartilage and its overall joint health. Proper nutrition, especially antioxidant supplementation, is critical in maintaining healthy joints. Glucosamine has been shown to promote the retention and normal regeneration of cartilage, support normal movement and flexibility of joints and promote joint comfort.
Frequently Asked Questions
What Are OPCs?
OPCs, or oligomeric proanthocyanidins, can help reduce free radical damage, support the strength and normal repair of connective tissue, and can support proper enzyme activity. OPCs can also help maintain normal histamine levels. Not limited to being just strong antioxidants, OPCs are also crucial in their role in supporting the circulatory system.
What Are Antioxidants, and Why Should I Give Them To My Pets?
Antioxidants are naturally occurring nutrients that help maintain optimum health by protecting against free radicals. Antioxidants are found in the body naturally as well as in many plants. Even cells that function normally generate large amounts of oxygen free radicals. Free radicals have an unpaired electron, making many of them reactive and destructive. When free radicals roam freely throughout the body unregulated by antioxidants, they can attack various healthy cell structures, including cell membranes, proteins, RNA and DNA.
Certain factors in everyday life encourage an increase in the formation of free radicals for humans and pets alike. These factors include the air we breathe, the water we drink, and the food we eat. Each one of these necessities can contain harmful reactants. We need a "neutralizer" in our body to rid our system of these harmful reactants and a strong and effective antioxidant is the best way to fight free radicals.
It is becoming increasingly apparent to veterinarians that antioxidant supplementation could very well provide optimal health support for dogs and cats in a manner similar to that experienced by humans. Both pets and their owners could benefit from a "neutralizer" operating in their systems that fight free radicals. A strong antioxidant is the best way to fight free radicals.
What is a bioflavonoid?
Bioflavonoids are complex organic plant compounds. Plants and fruits differ in colors based on the specific bioflavonoids they contain. An increasing number of clinical studies have shown how bioflavonoids support health. Bioflavonoids and OPCs play a key role in supporting cardiovascular health and maintaining vascular integrity. Bioflavonoids have been shown to support healthy circulation and cell vitality. Normal collagen renewal is promoted, which supports firmness of the skin, joint cartilage and connective tissue.
What is the history of OPCs?
In 1534, French explorer Jacques Cartier was leading an expedition up the St. Lawrence River. Trapped by bad weather, Cartier and his crew were forced to survive on a ration of salted meat and biscuits. Cartier's crew began to suffer from severe deficiency of vitamin C and showed symptoms of scurvy. Many crewmembers died before the surviving members encountered a friendly Native American who saved most of their lives. He told them to make a tea from the bark and needles of the pine tree to cure their malady. They complied and, as a result, Cartier and many crewmembers survived.
Some 400 years later, Professor Jacques Masquelier of the University of Bordeaux, France, read a book by Cartier detailing their expedition. He concluded that pine bark not only contained some vitamin C, but obviously was a good source of bioflavonoids, whose effects are similar to those of vitamin C. Further studies and research revealed that the pine bark contained an array of proanthocyanidins complexes. These compounds were also found in a variety of plants, including grape seeds, cranberries, peanut skin, lemon tree bark and citrus rinds. Masquelier termed the active ingredients of the pine bark "pycnogenols", which today are referred to in the scientific community as oligomeric proanthocyanidins, or OPCs.
Have you been Customized?
OPC-3 Pet Health.
Benefits:
° Combats free radicals
° Helps maintain healthy cholesterol levels
° Helps maintain healthy circulation
° Helps maintain joint flexibility
° Helps promote/support cardiovascular health
° Helps support visual health/visual acuity
° Potent free radical scavenger
° Promotes/Supports healthy blood vessel dilation
° Promotes/Supports healthy nitric oxide levels
° Supports healthy blood glucose levels
° Supports healthy platelet activity
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read less
view product demo print this page e-mail this page to a friend Key Ingredients:
Grape Seed Extract
Grape seed extract helps protect cells from free radical damage. Rich in polyphenols, beneficial compounds that have been shown to support normal circulation, grape seed extract can help maintain a healthy circulatory system.
Red Wine Extract
Red wine extract is a potent antioxidant that contains beneficial amounts of resveratrol. Resveratrol can promote normal blood platelet activity and it is believed that it is partially responsible for the cardiovascular health benefits associated with red wine.
Pine Bark Extract
Another strong antioxidant, pine bark extract has been shown to support normal circulation, the immune system and the strength of blood vessel walls.
Bilberry Extract
Bilberry extract is beneficial in promoting strong red blood cells and capillaries, specifically around the eyes and in the retina. Bilberry extract supports the capillaries in the body to help maintain optimal peripheral circulation.
Citrus Bioflavonoids
Citrus bioflavonoids are natural substances found in fruits and vegetables, nuts, and some tree barks. They counter the effects of free radical damage and also promote respiratory health.
Glucosamine
Glucosamine is an aminopolysaccharide (a combination of the amino acid - glutamine and a sugar - glucose). Glucosamine is concentrated in joint cartilage where it is incorporated in longer chains known as glycosaminoglycans and finally into very large structures known as proteoglycans. Glucosamine is naturally produced by the body, and is a key component of cartilage. Glucosamine promotes normal joint function and the normal production of synovial fluid, which lubricates the joints and promotes the normal regeneration of cartilage.
There are numerous European studies showing a clear benefit of glucosamine supplements for promoting joint health. Glucosamine may also support chondrocytes (cartilage cells) in the normal production of healthy new cartilage matrix (both collagen and proteoglycans).
Optimization by Blending
It has been suggested that several antioxidants blended together in moderate amounts may be more effective than high levels of one antioxidant. The blend of antioxidants in PetHealth™ OPC Formula Powder includes grape seed extract, red wine extract, pine bark extract, bilberry extract and citrus bioflavonoids. These antioxidants contain oligomeric proanthocyanidins, or OPCs. Much the same way antioxidants can help optimize a person's health, they can also be beneficial to our dogs and cats. Antioxidants help fight the damage caused by free radicals. They can also help support immune responses and support normal vaccine recognition in dogs and cats. Young animals can benefit tremendously from antioxidants. Antioxidants can help maintain optimum health in your animal's gastrointestinal and cardiovascular systems, liver, kidneys, eyes and immune system. Another important role of pet antioxidants is their ability to support immune-cell function for dogs and cats in their senior years.
read more read less
view product demo print this page e-mail this page to a friend
read more read less
view product demo print this page e-mail this page to a friend
read more read less
view product demo print this page e-mail this page to a friend What Makes This Product Unique?
A free radical is an atomic structure with an unpaired electron in its outermost shell. These unpaired electrons tend to be highly reactive, resulting in chemical reactions such as oxidation. Because they have one or more unpaired electrons, free radicals are highly unstable. They scavenge the body to grab or donate electrons, causing damage to cells, proteins and DNA. Free radicals are naturally occurring; however, air pollution, stress, cigarette smoke and heavy exercising all contribute to the creation of harmful free radicals. Free radicals can cause oxidative stress. Normally the animal’s body is able to protect itself from the damaging effects of free radicals, but if antioxidants are unavailable, or free radical production becomes excessive, oxidative stress can occur.
Antioxidants are natural cell protectors, neutralizing free radicals by pairing an electron to the outermost shell of radical oxygen molecules, rendering them harmless. Antioxidants are nutrients such as vitamins, minerals and enzymes that are capable of counteracting the damaging, but normal, effects of the physiological process of oxidation in bodily tissues. Antioxidants work in two ways, chain breaking and prevention. A chain-breaking antioxidant such as vitamins A, C and E, stabilize free radicals or cause them to decay into harmless atomic structures. A preventative antioxidant prevents the oxidation process by scavenging free radicals.
PetHealth™ OPC is a food supplement made from a combination of bilberry, grape seed, red wine, pine bark extracts, citrus extract bioflavonoids, and glucosamine, designed to promote healthy joints and provide a strong antioxidant defense. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to your pet’s body. Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. PetHealth OPC Formula with Glucosamine offers a unique, great-tasting powder that is sprinkled over your pet’s regular food. It represents the latest technology available today in naturally based pet food supplements. PetHealth OPC Formula is available in a tasty beef flavor that your pets will love - and youll love knowing that youre doing all you can to help your pets stay healthy and live long, healthy lives.
Pets face many of the same issues as humans. Many pet foods are over processed and have little nutritive value. Dogs and cats breathe in the same pollution as we do, inhaling harmful free radicals. Potent antioxidants like OPCs help to strengthen your pet’s free radical defenses. Antioxidants promote cardiovascular health, support healthy visual acuity, promote healthy blood vessel dilation and promote healthy platelet activity.
Your Pets and Joint Health
As pets become older, antioxidants become even more important in the fight against free radicals and their associated effects on cells in joints and other tissues. All animals are at risk for declining joint health. Many factors can affect joint health and the integrity of cartilage, including diet, genetic make-up and activity levels. The cold wintery months can also contribute to a decline in joint comfort. Each animals genetic code, for example, can influence the thickness and durability of its cartilage and its overall joint health. Proper nutrition, especially antioxidant supplementation, is critical in maintaining healthy joints. Glucosamine has been shown to promote the retention and normal regeneration of cartilage, support normal movement and flexibility of joints and promote joint comfort.
read more read less
view product demo print this page e-mail this page to a friend Frequently Asked Questions
What Are OPCs?
OPCs, or oligomeric proanthocyanidins, can help reduce free radical damage, support the strength and normal repair of connective tissue, and can support proper enzyme activity. OPCs can also help maintain normal histamine levels. Not limited to being just strong antioxidants, OPCs are also crucial in their role in supporting the circulatory system.
What Are Antioxidants, and Why Should I Give Them To My Pets?
Antioxidants are naturally occurring nutrients that help maintain optimum health by protecting against free radicals. Antioxidants are found in the body naturally as well as in many plants. Even cells that function normally generate large amounts of oxygen free radicals. Free radicals have an unpaired electron, making many of them reactive and destructive. When free radicals roam freely throughout the body unregulated by antioxidants, they can attack various healthy cell structures, including cell membranes, proteins, RNA and DNA.
Certain factors in everyday life encourage an increase in the formation of free radicals for humans and pets alike. These factors include the air we breathe, the water we drink, and the food we eat. Each one of these necessities can contain harmful reactants. We need a "neutralizer" in our body to rid our system of these harmful reactants and a strong and effective antioxidant is the best way to fight free radicals.
It is becoming increasingly apparent to veterinarians that antioxidant supplementation could very well provide optimal health support for dogs and cats in a manner similar to that experienced by humans. Both pets and their owners could benefit from a "neutralizer" operating in their systems that fight free radicals. A strong antioxidant is the best way to fight free radicals.
What is a bioflavonoid?
Bioflavonoids are complex organic plant compounds. Plants and fruits differ in colors based on the specific bioflavonoids they contain. An increasing number of clinical studies have shown how bioflavonoids support health. Bioflavonoids and OPCs play a key role in supporting cardiovascular health and maintaining vascular integrity. Bioflavonoids have been shown to support healthy circulation and cell vitality. Normal collagen renewal is promoted, which supports firmness of the skin, joint cartilage and connective tissue.
What is the history of OPCs?
In 1534, French explorer Jacques Cartier was leading an expedition up the St. Lawrence River. Trapped by bad weather, Cartier and his crew were forced to survive on a ration of salted meat and biscuits. Cartier's crew began to suffer from severe deficiency of vitamin C and showed symptoms of scurvy. Many crewmembers died before the surviving members encountered a friendly Native American who saved most of their lives. He told them to make a tea from the bark and needles of the pine tree to cure their malady. They complied and, as a result, Cartier and many crewmembers survived.
Some 400 years later, Professor Jacques Masquelier of the University of Bordeaux, France, read a book by Cartier detailing their expedition. He concluded that pine bark not only contained some vitamin C, but obviously was a good source of bioflavonoids, whose effects are similar to those of vitamin C. Further studies and research revealed that the pine bark contained an array of proanthocyanidins complexes. These compounds were also found in a variety of plants, including grape seeds, cranberries, peanut skin, lemon tree bark and citrus rinds. Masquelier termed the active ingredients of the pine bark "pycnogenols", which today are referred to in the scientific community as oligomeric proanthocyanidins, or OPCs.
read more read less
view product demo print this page e-mail this page to a friend Click here to view product label
read more read less
view product demo print this page e-mail this page to a friend Benefits:
° Combats free radicals
° Helps maintain healthy cholesterol levels
° Helps maintain healthy circulation
° Helps maintain joint flexibility
° Helps promote/support cardiovascular health
° Helps support visual health/visual acuity
° Potent free radical scavenger
° Promotes/Supports healthy blood vessel dilation
° Promotes/Supports healthy nitric oxide levels
° Supports healthy blood glucose levels
° Supports healthy platelet activity
Key Ingredients:
Grape Seed Extract
Grape seed extract helps protect cells from free radical damage. Rich in polyphenols, beneficial compounds that have been shown to support normal circulation, grape seed extract can help maintain a healthy circulatory system.
Red Wine Extract
Red wine extract is a potent antioxidant that contains beneficial amounts of resveratrol. Resveratrol can promote normal blood platelet activity and it is believed that it is partially responsible for the cardiovascular health benefits associated with red wine.
Pine Bark Extract
Another strong antioxidant, pine bark extract has been shown to support normal circulation, the immune system and the strength of blood vessel walls.
Bilberry Extract
Bilberry extract is beneficial in promoting strong red blood cells and capillaries, specifically around the eyes and in the retina. Bilberry extract supports the capillaries in the body to help maintain optimal peripheral circulation.
Citrus Bioflavonoids
Citrus bioflavonoids are natural substances found in fruits and vegetables, nuts, and some tree barks. They counter the effects of free radical damage and also promote respiratory health.
Glucosamine
Glucosamine is an aminopolysaccharide (a combination of the amino acid - glutamine and a sugar - glucose). Glucosamine is concentrated in joint cartilage where it is incorporated in longer chains known as glycosaminoglycans and finally into very large structures known as proteoglycans. Glucosamine is naturally produced by the body, and is a key component of cartilage. Glucosamine promotes normal joint function and the normal production of synovial fluid, which lubricates the joints and promotes the normal regeneration of cartilage.
There are numerous European studies showing a clear benefit of glucosamine supplements for promoting joint health. Glucosamine may also support chondrocytes (cartilage cells) in the normal production of healthy new cartilage matrix (both collagen and proteoglycans).
Optimization by Blending
It has been suggested that several antioxidants blended together in moderate amounts may be more effective than high levels of one antioxidant. The blend of antioxidants in PetHealth™ OPC Formula Powder includes grape seed extract, red wine extract, pine bark extract, bilberry extract and citrus bioflavonoids. These antioxidants contain oligomeric proanthocyanidins, or OPCs. Much the same way antioxidants can help optimize a person's health, they can also be beneficial to our dogs and cats. Antioxidants help fight the damage caused by free radicals. They can also help support immune responses and support normal vaccine recognition in dogs and cats. Young animals can benefit tremendously from antioxidants. Antioxidants can help maintain optimum health in your animal's gastrointestinal and cardiovascular systems, liver, kidneys, eyes and immune system. Another important role of pet antioxidants is their ability to support immune-cell function for dogs and cats in their senior years.
What Makes This Product Unique?
A free radical is an atomic structure with an unpaired electron in its outermost shell. These unpaired electrons tend to be highly reactive, resulting in chemical reactions such as oxidation. Because they have one or more unpaired electrons, free radicals are highly unstable. They scavenge the body to grab or donate electrons, causing damage to cells, proteins and DNA. Free radicals are naturally occurring; however, air pollution, stress, cigarette smoke and heavy exercising all contribute to the creation of harmful free radicals. Free radicals can cause oxidative stress. Normally the animal’s body is able to protect itself from the damaging effects of free radicals, but if antioxidants are unavailable, or free radical production becomes excessive, oxidative stress can occur.
Antioxidants are natural cell protectors, neutralizing free radicals by pairing an electron to the outermost shell of radical oxygen molecules, rendering them harmless. Antioxidants are nutrients such as vitamins, minerals and enzymes that are capable of counteracting the damaging, but normal, effects of the physiological process of oxidation in bodily tissues. Antioxidants work in two ways, chain breaking and prevention. A chain-breaking antioxidant such as vitamins A, C and E, stabilize free radicals or cause them to decay into harmless atomic structures. A preventative antioxidant prevents the oxidation process by scavenging free radicals.
PetHealth™ OPC is a food supplement made from a combination of bilberry, grape seed, red wine, pine bark extracts, citrus extract bioflavonoids, and glucosamine, designed to promote healthy joints and provide a strong antioxidant defense. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to your pet’s body. Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. PetHealth OPC Formula with Glucosamine offers a unique, great-tasting powder that is sprinkled over your pet’s regular food. It represents the latest technology available today in naturally based pet food supplements. PetHealth OPC Formula is available in a tasty beef flavor that your pets will love - and youll love knowing that youre doing all you can to help your pets stay healthy and live long, healthy lives.
Pets face many of the same issues as humans. Many pet foods are over processed and have little nutritive value. Dogs and cats breathe in the same pollution as we do, inhaling harmful free radicals. Potent antioxidants like OPCs help to strengthen your pet’s free radical defenses. Antioxidants promote cardiovascular health, support healthy visual acuity, promote healthy blood vessel dilation and promote healthy platelet activity.
Your Pets and Joint Health
As pets become older, antioxidants become even more important in the fight against free radicals and their associated effects on cells in joints and other tissues. All animals are at risk for declining joint health. Many factors can affect joint health and the integrity of cartilage, including diet, genetic make-up and activity levels. The cold wintery months can also contribute to a decline in joint comfort. Each animals genetic code, for example, can influence the thickness and durability of its cartilage and its overall joint health. Proper nutrition, especially antioxidant supplementation, is critical in maintaining healthy joints. Glucosamine has been shown to promote the retention and normal regeneration of cartilage, support normal movement and flexibility of joints and promote joint comfort.
Frequently Asked Questions
What Are OPCs?
OPCs, or oligomeric proanthocyanidins, can help reduce free radical damage, support the strength and normal repair of connective tissue, and can support proper enzyme activity. OPCs can also help maintain normal histamine levels. Not limited to being just strong antioxidants, OPCs are also crucial in their role in supporting the circulatory system.
What Are Antioxidants, and Why Should I Give Them To My Pets?
Antioxidants are naturally occurring nutrients that help maintain optimum health by protecting against free radicals. Antioxidants are found in the body naturally as well as in many plants. Even cells that function normally generate large amounts of oxygen free radicals. Free radicals have an unpaired electron, making many of them reactive and destructive. When free radicals roam freely throughout the body unregulated by antioxidants, they can attack various healthy cell structures, including cell membranes, proteins, RNA and DNA.
Certain factors in everyday life encourage an increase in the formation of free radicals for humans and pets alike. These factors include the air we breathe, the water we drink, and the food we eat. Each one of these necessities can contain harmful reactants. We need a "neutralizer" in our body to rid our system of these harmful reactants and a strong and effective antioxidant is the best way to fight free radicals.
It is becoming increasingly apparent to veterinarians that antioxidant supplementation could very well provide optimal health support for dogs and cats in a manner similar to that experienced by humans. Both pets and their owners could benefit from a "neutralizer" operating in their systems that fight free radicals. A strong antioxidant is the best way to fight free radicals.
What is a bioflavonoid?
Bioflavonoids are complex organic plant compounds. Plants and fruits differ in colors based on the specific bioflavonoids they contain. An increasing number of clinical studies have shown how bioflavonoids support health. Bioflavonoids and OPCs play a key role in supporting cardiovascular health and maintaining vascular integrity. Bioflavonoids have been shown to support healthy circulation and cell vitality. Normal collagen renewal is promoted, which supports firmness of the skin, joint cartilage and connective tissue.
What is the history of OPCs?
In 1534, French explorer Jacques Cartier was leading an expedition up the St. Lawrence River. Trapped by bad weather, Cartier and his crew were forced to survive on a ration of salted meat and biscuits. Cartier's crew began to suffer from severe deficiency of vitamin C and showed symptoms of scurvy. Many crewmembers died before the surviving members encountered a friendly Native American who saved most of their lives. He told them to make a tea from the bark and needles of the pine tree to cure their malady. They complied and, as a result, Cartier and many crewmembers survived.
Some 400 years later, Professor Jacques Masquelier of the University of Bordeaux, France, read a book by Cartier detailing their expedition. He concluded that pine bark not only contained some vitamin C, but obviously was a good source of bioflavonoids, whose effects are similar to those of vitamin C. Further studies and research revealed that the pine bark contained an array of proanthocyanidins complexes. These compounds were also found in a variety of plants, including grape seeds, cranberries, peanut skin, lemon tree bark and citrus rinds. Masquelier termed the active ingredients of the pine bark "pycnogenols", which today are referred to in the scientific community as oligomeric proanthocyanidins, or OPCs.
Have you been Customized?
Saturday, December 19, 2009
Market America Motives® Lustrafy Mascara
Lustrafy Mascara is considered #1 according to all the reviews on www.Buzzillions.com
Tip from customer manager Andrew Rosser at www.CustomizeME.com
1-800-717-7802
Friday, December 18, 2009
Hard Drive Back up
Carbonite Online Backup
Unlimited online backup for one flat fee. Free trial, no credit card required. Secure and encrypted for your privacy. Easy, on-demand restore. Securely backup your photos, emails, financial documents, music and more over internet.
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use coupon code " cust50 "
tip from customer manager
Andrew Rosser
www.CustomizeME.com
1-800-717-7802
Earn 2% Cash Back ...Ask Me How
Unlimited online backup for one flat fee. Free trial, no credit card required. Secure and encrypted for your privacy. Easy, on-demand restore. Securely backup your photos, emails, financial documents, music and more over internet.
To get 50% off
use coupon code " cust50 "
tip from customer manager
Andrew Rosser
www.CustomizeME.com
1-800-717-7802
Earn 2% Cash Back ...Ask Me How
Tuesday, December 15, 2009
www.CustomizeME.com Get Paid To Shop
SEARCH, SHOP, SAVE AND SHARE
Use www.CustomizeME.com to find great deals on all the products you want from all the stores you love and trust. Earn 2% cash back on purchases and a half percent cash on the purchases of others you refer. Start earning now at www.CustomizeME.com!
Use www.CustomizeME.com to find great deals on all the products you want from all the stores you love and trust. Earn 2% cash back on purchases and a half percent cash on the purchases of others you refer. Start earning now at www.CustomizeME.com!
Tuesday, December 08, 2009
Vitamin D May Boost Lymphoma Survival
Vitamin D May Boost Lymphoma Survival
Study Shows Low Vitamin D Levels Boost Risk of Non-Hodgkin's Lymphoma
By Kelli Miller Stacy
WebMD Health News
Reviewed by Louise Chang, MD
Dec. 7, 2009 -- Healthy levels of vitamin D may help patients with a certain type of non-Hodgkin's lymphoma live longer.
Researchers at the Mayo Clinic have discovered that patients with diffuse large B-cell lymphoma (DLBCL) and low vitamin D levels are two times more likely to die from the cancer than patients with optimal levels. Deficient vitamin D levels also increased the chances of cancer progression.
"These are some of the strongest findings yet between vitamin D and cancer outcome," Matthew Drake, MD, PhD, an endocrinologist at Mayo Clinic in Rochester, Minn., says in a news release. "While these findings are very provocative, they are preliminary and need to be validated in other studies. However, they raise the issue of whether vitamin D supplementation might aid in treatment for this malignancy."
Non-Hodgkin's lymphoma is a cancer of the white blood cells. DLBCL is the most common type of non-Hodgkin's lymphoma. The fast-growing cancer usually occurs in adults.
The new findings are based on a study of 374 patients who were newly diagnosed with DLBCL. Blood testing showed that half of them had a vitamin D deficiency. Vitamin D deficiency was defined in this study as less than 25 nanogram/milliliter of total vitamin D in the blood.
Those with deficient vitamin D levels were 1.5 times more likely to have the cancer progress, and had a twofold increase in the risk for dying.
The findings add credence to the growing body of evidence that suggests vitamin D plays an important role in cancer risk and survival. But the American diet usually doesn't provide enough vitamin D. Few foods and drinks naturally contain the vitamin, although some, such as milk, cereals, and certain brands of orange juice, are fortified with it.
The body's greatest supply of vitamin D comes from the sun. The body makes vitamin D after direct exposure to the sun's UV rays. One cause of vitamin D deficiency is limited exposure to sunlight.
"The exact roles that vitamin D might play in the initiation or progression of cancer is unknown, but we do know that the vitamin plays a role in regulation of cell growth and death, among other processes important in limiting cancer," Drake says.
The study team will present their results this week at the 51st annual meeting of the American Society of Hematology in New Orleans.
For a good vitamin D product
visit --- www.CustomizeME.com
Study Shows Low Vitamin D Levels Boost Risk of Non-Hodgkin's Lymphoma
By Kelli Miller Stacy
WebMD Health News
Reviewed by Louise Chang, MD
Dec. 7, 2009 -- Healthy levels of vitamin D may help patients with a certain type of non-Hodgkin's lymphoma live longer.Researchers at the Mayo Clinic have discovered that patients with diffuse large B-cell lymphoma (DLBCL) and low vitamin D levels are two times more likely to die from the cancer than patients with optimal levels. Deficient vitamin D levels also increased the chances of cancer progression.
"These are some of the strongest findings yet between vitamin D and cancer outcome," Matthew Drake, MD, PhD, an endocrinologist at Mayo Clinic in Rochester, Minn., says in a news release. "While these findings are very provocative, they are preliminary and need to be validated in other studies. However, they raise the issue of whether vitamin D supplementation might aid in treatment for this malignancy."
Non-Hodgkin's lymphoma is a cancer of the white blood cells. DLBCL is the most common type of non-Hodgkin's lymphoma. The fast-growing cancer usually occurs in adults.
The new findings are based on a study of 374 patients who were newly diagnosed with DLBCL. Blood testing showed that half of them had a vitamin D deficiency. Vitamin D deficiency was defined in this study as less than 25 nanogram/milliliter of total vitamin D in the blood.
Those with deficient vitamin D levels were 1.5 times more likely to have the cancer progress, and had a twofold increase in the risk for dying.
 |
| Isotonix Vitamin D with K2 |
The body's greatest supply of vitamin D comes from the sun. The body makes vitamin D after direct exposure to the sun's UV rays. One cause of vitamin D deficiency is limited exposure to sunlight.
"The exact roles that vitamin D might play in the initiation or progression of cancer is unknown, but we do know that the vitamin plays a role in regulation of cell growth and death, among other processes important in limiting cancer," Drake says.
The study team will present their results this week at the 51st annual meeting of the American Society of Hematology in New Orleans.
For a good vitamin D product
visit --- www.CustomizeME.com
Monday, November 30, 2009
Market America 2% Cashback
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Thursday, November 19, 2009
Probiotics intake beneficial against infections in kids: study
Probiotics intake beneficial against infections in kids: study
Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: A randomized, double-blind, placebo-controlled trial☆
Received 17 July 2009; accepted 28 September 2009. published online 05 October 2009.
Corrected Proof
Corrected Proof
Summary
Background & aims
The aim of our study was to investigate the role of Lactobacillus GG (LGG) in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers.
Methods
We conducted a randomized, double-blind, placebo-controlled trial in 281 children who attend day care centers. They were randomly allocated to receive LGG at a dose of 109 colony-forming units in 100
ml of a fermented milk product (LGG group, n=139) or placebo that was the same post-pasteurized fermented milk product without LGG (placebo group, n=142) during the 3-month intervention period.
ml of a fermented milk product (LGG group, n=139) or placebo that was the same post-pasteurized fermented milk product without LGG (placebo group, n=142) during the 3-month intervention period.Results
Compared to the placebo group, children in the LGG group had a significantly reduced risk of upper respiratory tract infections (RR 0.66, 95% CI 0.52 to 0.82, NNT 5, 95% CI 4 to 10), a reduced risk of respiratory tract infections lasting longer than 3 days (RR 0.57, 95% CI 0.41 to 0.78, NNT 5, 95% CI 4 to 11), and a significantly lower number of days with respiratory symptoms (p<0.001). There was no risk reduction in regard to lower respiratory tract infections (RR 0.82, 95% CI 0.24 to 2.76). Compared with the placebo group, children in the LGG group had no significant reduction in the risk of gastrointestinal infections (RR 0.63, 95% CI 0.38 to 1.06), vomiting episodes (RR 0.60, 95% CI 0.29 to 1.24), and diarrheal episodes (RR 0.63, 95% CI 0.35 to 1.11) as well as no reduction in the number of days with gastrointestinal symptoms (p=0.063).
<0.001). There was no risk reduction in regard to lower respiratory tract infections (RR 0.82, 95% CI 0.24 to 2.76). Compared with the placebo group, children in the LGG group had no significant reduction in the risk of gastrointestinal infections (RR 0.63, 95% CI 0.38 to 1.06), vomiting episodes (RR 0.60, 95% CI 0.29 to 1.24), and diarrheal episodes (RR 0.63, 95% CI 0.35 to 1.11) as well as no reduction in the number of days with gastrointestinal symptoms (p=0.063).Conclusion
LGG administration can be recommended as a valid measure for decreasing the risk of upper respiratory tract infections in children attending day care centers.
Abbreviations: LGG, Lactobacillus GG, RR, relative risk, CI, 95% confidence interval, NNT, number needed to treat
a Referral Center for Pediatric Gastroenterology and Nutrition, Children's Hospital Zagreb, Klaićeva 16, Zagreb, Croatia
b Department for Otorinolaringology, General Hospital Dr. Ivo Pedišić, J.J. Strossmayera 59, Sisak, Croatia
c 2nd Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland
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Tuesday, November 17, 2009
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