Study unlocks Pycnogenol’s skin health mechanism

A recent study of 20 women between the ages of 55 and 68 shows that taking 75mg of Pycnogenol for 12 weeks improved skin elasticity. 

Twelve weeks of supplementation with the Pycnogenol branded part was related with increases in skin agility and hydration, and an enlarge in the prolongation of hyaluronic acid in skin by 44%, according to commentary published in Skin Pharmacology and Physiology.


Hyaluronic acid is a component of the pattern between cells (extracellular matrix) that occurs of course in the body until the age of about 30, after that levels beginning to decrease. The lessen is accepted to fool around a purpose in the aging process, specific a relapse in the extracellular pattern and an enlarge in the arrangement of wrinkles.

Indeed, the hunger bellow remove was moreover related with a 3% shrinking in skin wrinkles, according to researchers from Leibniz Research Institute for Environmental Medicine (IUF) in Dusseldorf, Germany and Horphag Research, the firm at the back the ingredient.
“The present investigate confirms at a molecular turn the profitable belongings Pycnogenol supplementation might supply to human skin,” wrote the researchers. 
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Study unlocks Pycnogenol’s skin health mechanism

Isotonix OPC-3 (OPC-3) contains the only isotonic form of Pycnogenol(r) in the world. Pycnogenol is a natural plant extract from the bark of the French maritime pine tree and the most clinically researched and potent bioflavonoid.* Isotonic, which means; same pressure & bears the same chemical resemblance of the body & blood, plasma and tears.  All fluids in the body have a certain concentration, referred to as osmotic pressure. The body & common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body & metabolism, it must be transported in an isotonic state. Isotonix(r) dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

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The Science and

Advantage of Isotonix

Healthy supplementation is about more than just ingredients; it’s about delivery and absorption. by Dr. Jim Wilmer

The Advantage

When we eat food, drink a beverage, or ingest most nutritional supplements, the stomach must secrete diluting juices, enzymes, hydrochloric acid and at least one vitamin-binding protein to begin the process of digestion. This process requires both energy and time — about 40 minutes or more, depending on the size of the meal. Isotonix products are delivered into the small intestine nutritionally concentrated, maximizing the opportunity for absorption of nutrients across cell membranes.

What Is Isotonic?
Isotonix® is a word, and that’s all to a lot of people. What does it mean? Broken down to its roots, “iso” means “the same” and “tonic” means “pressure” or “tone.” When isotonic is used to describe solutions for human consumption, it means having the same fluid pressure as body fluids. Tears, blood, plasma, lymph and other body fluids are all isotonic.

When we ingest food, gastric (or stomach) juice is secreted onto the food and muscular contractions of the stomach mix the contents until a reasonably uniform solution is achieved. The solutions of food (or chyme) that enter the small intestine for absorption are made isotonic by the action of the stomach in a time-consuming process. The fluid pressure of food or isotonic solutions across semi-permeable membranes, such as the walls of the small intestine, is generally referred to as having a particular osmolarity or tonicity. It can be said that when solutions on opposite sides of the membrane have the same osmolarity, they are iso-osmotic or iso-tonic. Normal human blood serum (the fluid portion without cells and platelets) has an osmolarity of 288mOs/kg, as do most other fl uids in the body. Therefore, in physiological terms, when a solution’s osmolarity is the same, or nearly the same, as that of normal human blood serum, it is referred to as isotonic.

Gastric Emptying Time

Why is gastric emptying so important? The answer is simply this: the longer the supplements stay in the stomach, the longer the time before absorption can begin, because no appreciable absorption occurs from the stomach.  Why is gastric emptying time stressed when talking about Isotonix?  Because the fastest emptying time occurs when isotonic solutions enter the stomach.  When the biological sensors in the gastrointestinal tract detect that the ingested solution is isotonic and at a correct pH, the pyloric or duodenal valve at the lower end of the stomach remains open and the solution is squirted into the small intestine. Absorption of the nutrients by the intestinal mucosa then starts to occur.

Concentration and Absorption

Concentration and absorption are factors that go hand in hand for the proper use of nutritional supplements.  Concentration, the amount of nutrient dissolved in a given amount of solution, is directly related to the efficiency of nutritional absorption. It is known that the greater the concentration (as milligrams of nutrient per milliliter of solution at the absorption site), the greater

the rate and amount of absorption. Because Isotonix solutions experience little dilution in the gastrointestinal tract, they arrive at the absorption sites in high concentration to assure effi cient absorption.  Isotonix®

Jim L. Wilmer, Ph. D. is Chief Science Officer at Market America and has been employed by the company for over 15 years. He earned a doctorate from Cornell University in environmental toxicology (1991), a master of science in biolog y from East Tennessee State University (1974), and a bachelor of science from Wofford College (1972). Dr. Wilmer has 44 peer-reviewed publications in journals, including Cancer Research, Journal of Investigative Dermatology, Mutation Research, Environmental Mutagenesis, Cell Biology and Toxicology, Cytogenetics and Cell Genetics, Angiology, and Phytotherapy Research.