Showing posts with label Vitamin D. Show all posts
Showing posts with label Vitamin D. Show all posts

Wednesday, November 19, 2014

5 Signs You Might Be Vitamin Deficient

Do you ever feel like your body is trying to tell you something? Like when you’re feeling a little tired, you may be a bit grumpy or teary eyed. Or when you know you may be on the verge of catching a cold or winter flu, you start feeling sort of lethargic and perhaps get a funny feeling in the back of your throat? Body signals work in ways to do just that – let you know when body functions are there highest and best function, but also give you sign when something is a little off. Staying in tune with your body is essential for keeping everything in top form – from muscles to organs and even your mind. And, being sure you’re getting all the vitamins and nutrients you need is half the battle when it comes to staying in tip top shape. Here’s a look at how your body signals that you’re vitamin deficient – signs to look out for and how to combat with healthy choices and vitamin supplements, if necessary. 





1. Do you find yourself getting bad muscle cramps in spots like your toes, the backs of your legs or even the arches of your feet? This could mean you may be lacking in potassium, calcium or even magnesium.  Adding almonds, cherries, apples, hazelnuts, squash, leafy greens, bananas and broccoli just might do the trick.
2. Getting the tingles in your feet and hands? It’s pretty wild, but this can be related to a deficiency in B vitamins. Try loading up on pinto, black and kidney beans, while also mixing it up with asparagus, oysters, mussels, eggs and spinach.
3. How about little white or red bumps – often on your buttocks, arms and cheeks? Seems odd, right? You may be a bit deficient in vitamins A, D and perhaps need to increase your essential fatty acid intake. Adding more healthy fats to your diet – found in things like sardines, salmon, walnuts, flax, chia and almonds can easily up the essential fatty acids necessary for staying on top of your game. Leafy greens, bright colored veggies (like bell peppers and carrots) are loaded with vitamin A and often, vitamin D deficiencies can be easily solved with a supplement (talk to your doc about this one).
4. Have you noticed a whole heap of things going a little off with your body? Like dry hair and skin, mood swings and even joint and muscle aches. Any combo of these symptoms could signal a deficiency in vitamin C. From supplements to dietary additions, getting a bit more vitamin C in your diet is pretty easy. Of course, the common citrus fruit (oranges and lemons) are a great source, but vitamin C can also be found in guava, red bell peppers, kiwi, Brussels sprouts and even cantaloupe.
5. Are you noticing little cracks at the corners of your mouth? Well, believe it or not – that may be your body telling you it’s time to get a little more iron and maybe even some zinc and B vitamins. This is an easy fix by switching up your diet just a bit. Try eating more salmon, eggs, tuna and poultry. Adding in some kale, swiss chard, broccoli and bell peppers will even help your body absorb that iron a little better.
No matter what, paying attention to your body is absolutely essential when it comes to staying healthy – you are the only one who knows exactly when something is off or just isn’t quite right. Got questions about these symptoms and how to solve? Definitely talk to your doctor.

Friday, February 28, 2014

Vitamin D may have direct effect on brain development, social behavior and autism


Vitamin D may have direct effect on brain development, social behavior and autism

Vitamin D could have a 'critical influence' levels of serotonin in the brain and may directly effect social behaviors associated with Autism Spectrum Disorder (ASD), according to new research.

Writing in The FASEB Journal, the study suggests that adequate levels of vitamin D may be required to produce serotonin in the brain where it shapes the structure and wiring of the brain, acts as a neurotransmitter, and affects social behavior.
    
Led by Professor Bruce Ames of Children's Hospital Oakland Research Institute (CHORI) in the US, the study demonstrates that serotonin, oxytocin, and vasopressin three brain hormones that affect social behavior are all activated by vitamin D.

“We present evidence that vitamin D hormone (calcitriol) activates the transcription of the serotonin synthesizing gene tryptophan hydroxylase 2 (TPH2) in the brain at a vitamin D response element (VDRE) and represses the transcription of TPH1 in tissues outside the bloodbrain
barrier at a distinct VDRE suggesting a causal link between the sunshine vitamin, serotonin and autism,” wrote Ames and his colleagues.

Isotonix Vitamin D with K2
They noted that autism, which is characterized by abnormal social behavior, has previously been linked to low levels of serotonin in the brain and to low vitamin D levels, but no mechanism has linked the two until now.

Indeed, Ames and his team suggested that their study sheds light on, and offers a mechanism to explain many of the known, but previously not understood facts about autism.

“This mechanism explains how low vitamin D hormone levels result in aberrant serotonin synthesis, subsequently leading to abnormal brain development,” wrote the research team. “Low vitamin D hormone levels during foetal and neonatal development could result in poor TPH2 expression and subsequently reduced serotonin concentrations in the developing brain.”

They added that such a suggestion may mean that adequate vitamin D hormone levels during pregnancy, as well as nutritional intake of tryptophan and vitamin D during early childhood, “may have a critical influence on brain serotonin levels and, thus, on the structure and neural wiring of the brain.”
Learn more here by Nathan Gray 

Thursday, January 17, 2013

Calcium and Vitamin D Boost Body Fat Loss

Calcium and Vitamin D Boost Body Fat Loss
by Olivia Mungal

If you, like millions of other people, recently just started a new diet for your New Year’s Resolution, you may be in luck. A recent study shows adding calcium and vitamin D supplements to a calorie-restricted diet may boost the loss of body fat more than the diet alone.

The Study 

Chinese researchers from the Shanghai Institute of Health Sciences in China tested 52 obese or overweight adults. All participants were asked to follow an calorie-restricted diet (-500 kcal/daily), but half were randomly selected to take a Calcium and Vitamin D supplement, and the other half were given placebos.

"The calcium and vitamin D group achieved 55.6% augmentation of fat mass loss compared with the control, despite the face that there was no significant difference in body weight change between groups,” researchers noted in the Nutrition Journal.
About a quarter of the US adult population is obese, and even more are considered overweight. Over 300,000,000 adults are considered obese worldwide, according to statistics from the WHO and the International Obesity Task Force.

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Isotonix® Calcium Plus
What Makes Isotonix® Calcium Plus Unique?

Calcium is essential for building and maintaining strong bones. Isotonix® Calcium Plus provides the body with an optimal blend of calcium, vitamin D3, magnesium, vitamin C and boron in an efficient isotonic solution that is readily absorbed by the body. Isotonix dietary supplements are a replica of the body's own fluids, such as tears, plasma and breast milk. All fluids in the human body have a certain concentration, which is called the osmotic pressure. The body's common osmotic pressure, which is isotonic, allows a consistent maintenance of all body tissues. In order for a substance to be used in the body's metabolism, it must be changed to the isotonic state.*

The efficiency of absorption is also affected by the digestive system. All substances that are used in the stomach go through a degradation process (breakdown) before they can be passed through the opening from the stomach to the small intestine to allow absorption. The digestive process can cause substances to lose some nutritive value, and this whole process takes time!

The secret of the isotonic process is probably now becoming clear! When an isotonic substance enters the body, it will be absorbed into the bloodstream rapidly. With isotonic fluids, little nutritive value is lost making the absorption of nutrients highly efficient. There is nothing artificial about it. An isotonic fluid is nature's own nutrient delivery system.

Isotonix Calcium Plus paves the way for powerful results since it is in an isotonic form rather than a tablet. Calcium in tablet form is difficult for your body to absorb. People may fail to absorb tablet calcium supplements because the calcium supplement is not blended with vitamin D and magnesium; these are necessary to aid in the absorption and use of calcium. 

Even if the calcium tablet is blended correctly, it may be difficult for the body to utilize or break down the calcium. One explanation may be that many calcium brands use calcium from eggshell or oyster shell. These may not be well absorbed by the body. Another reason calcium may not be absorbed from a tablet is because of DCP, which is a binding agent used to hold the tablet together. DCP does not break down in the body.
  
In addition to binders, some calcium supplements may have additives such as chlorine and other chemicals. Even assuming no binders are used in the calcium tablet, the body must still break down a hard-press 
ed tablet into a usable form. If the tablet cannot be broken down sufficiently in the stomach, then the calcium will not be absorbed. If you can't break down the calcium, your body is robbed of the calcium needed to support bodily functions.

Ordinary calcium tablets require stomach acid to dissolve their compounds, but Isotonix Calcium Plus has no need of stomach acid to be utilized. It delivers an efficient calcium solution that is more readily absorbed by the intestine. Its natural lemon-lime flavor is preferable to the chalky taste of typical chewable calcium wafers or tablets. 

Many calcium supplements exist in the marketplace, but only Market America's Isotonix Calcium Plus delivers a potent package of calcium and complementary nutrients through an isotonic system of delivery. This translates into a lower cost overall when compared to calcium supplements in pill form by making more of the active ingredients available to the body. Don't be misled by ingredient amounts. What really counts is the amount of active ingredients that your body can ultimately use. 

Friday, October 26, 2012

NBA Basketball superstar from the NY Knick's Carmelo Anthony has teamed with internet retailer Market America/SHOP.COM to launch Isotonix® Champion Blend Plus



NBA Basketball superstar from the NY Knick's Carmelo Anthony has teamed with internet 
retailer Market America/SHOP.COM to launch Isotonix® Champion Blend Plus, the latest offering in the company’s advanced health & nutrition supplement line.  The launch party drew a huge crowd of celebrities and athletes – including Tommy Hilfiger, Irve Gotti, Scottie and Larsa Pippen, Caroline Manzo, Maxwell, and of course La La Anthony was on hand to support her man at the launch of Champion Blend Plus. There were even a host of Carmelo’s Kicks teammates here tonight – with Jason Kidd, Amar’e Stoudemire, Marcus Camby, Baron Davis, Kurt Thomas, J.R. Smith in the house
Isotonix Champion Blend Plus
This Isotonix formula supplement helps you perform at your best.  This formula is changing the game – and changing the way you take vitamins! Champion Blend Plus has exactly what the body needs to support its muscles with essential nutrients, keep the body’s defenses up with powerful antioxidants, and provide a boost of energy from great vitamins, Isotonix Champion Blend Plus is everything one needs to be a true champion. 
“I’m always looking for the best thing to keep my body working at its peak, whether it’s during my workouts or in the heat of the game,” Carmelo said. “I need my muscles strong and responsive. I need my body feeling healthy and fresh. So I started talking to JR and Loren, asking if they had something that could help.”
Market America/SHOP.COM President and Chief Executive Officer JR Ridinger and Senior Vice President Loren Ridinger helped lead the development of this cutting-edge supplement, one that can help not only world-class athletes, but anyone stay in shape and feel great.
Added Loren Ridinger: “Carmelo really pushed us to create this product, and we’re glad he did. Market America and the Isotonix family of products have added a true champion to their lineup – in more ways than one.”
The product, available through SHOP.COM, combines Branched Chain Amino Acids to help retain muscles; the powerful antioxidant Pycnogenol®, the perfect ingredient for those living an active healthy lifestyle as it helps combat aggressive free radicals before they cause harm to the body; and activated B-vitamins, proven to provide the body with a boost of energy. *
Tommy Hilfiger, Loren Ridinger with Carmelo Anthony
Isotonix Champion Blend Plus utilizes the scientifically-proven Isotonix Delivery System – which allows for vitamins and nutrients to be absorbed by the body faster and more efficiently than other delivery systems.
“Performance. Defense. Energy. That’s what this product is all about,” said JR Ridinger. “We are so proud of Carmelo’s involvement in bringing this product to everyone. Now everybody can take a shot at being a champion.”
Added Carmelo: “They didn’t have exactly what I was looking for, so they created it. And they took it to the next level. No more pills – now you can drink your vitamins.”

Primary Benefits of Isotonix® Champion Blend Plus *:

  • Promotes healthy muscle growth and muscle retention
  • Helps reduce muscle fatigue
  • Supports bone health
  • Provides antioxidant protection to minimize the effects of free radicals
  • Contains activated forms of select B vitamins to ensure optimal utilization by the body
  • Increases energy
  • Promotes cardiovascular health
  • Promotes optimal immune functions












What Makes Isotonix® Champion Blend Plus Unique?
Isotonix Champion Blend Plus is exactly what your body needs to preserve your muscles with essential nutrients, keep your body’s defenses up with powerful antioxidants, and provide you with a huge boost of energy from great vitamins. Performance, defense, energy – everything you need to be a true champion.

Performance is the key measure of success, which is why Isotonix Champion Blend Plus is formulated to help benefit the performance of active adults with Instantized Branch Chain Amino Acids. Being both instantized and isotonic, you’re getting a product with superior bioavailability, allowing for faster absorption.

To defend your body from the effects of free radicals, Isotonix Champion Blend Plus provides an array of antioxidant benefits, thanks to the inclusion of Pycnogenol® - the isotonic form of which is exclusive worldwide to Market America – to help combat free radicals before they cause oxidative stress to the body.

Finally, all champions need the energy not only to compete, but to train, by including the activated forms of B vitamins – which are more readily processed by the body and thereby increase their effectiveness.

And, thanks to the utilization of the most advanced nutrient delivery system available anywhere - Isotonix® - you can be sure your body is getting the best - rapid absorption, no binders or fillers and maximum results. It all adds up to an unmatched product for the person looking to raise their game to the next level - Isotonix Champion Blend Plus.

Key Ingredients Found in Isotonix® Champion Blend Plus
Pycnogenol® (25 mg) 
Pycnogenol is a natural plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. This unspoiled and natural forest environment is the unique source of pine bark. Pycnogenol is one of the most researched ingredients in the natural product marketplace. Published findings have demonstrated Pycnogenol’s wide array of support to the body. Pine bark extract is an all-natural combination of procyanidins, bioflavonoids and organic acids. The extract has three basic properties — it is a powerful antioxidant, selectively binds to collagen and elastin, and promotes the normal production of endothelial nitric oxide, which promotes the normal dilation of blood vessels. As one of the most powerful natural scavengers of free radicals, Pycnogenol combats free radicals before they cause oxidative stress to vital organs. Its super-antioxidant capabilities promote cardiovascular health*


Instantized Branch Chain Amino Acids (IBCAAs) (3 g)
Branched chain amino acids (BCAA) are considered essential, as they cannot be synthesized by the human body and, therefore, must be consumed through diet or supplementation. Unlike other amino acids, BCAA are used primarily by skeletal muscle, making up 30-35 percent of the muscle tissue itself. These amino acids promote healthy muscle growth and retention. As aging occurs, the body’s ability to build and retain muscle tissue or size is reduced, which can result in weakness and frailty. Research has shown that supplementation with BCAA promotes muscle retention in older adults. Additionally, it has been shown that supplementation of BCAA during exercise supports muscle protein synthesis and inhibits protein catabolism (breakdown) and muscle fatigue. By using instantized BCAAs within the isotonic system, there is a quicker dissolution and increased bioavailability.*


Activated B Vitamins (Folinic Acid, Methylcobalamin and Pyridoxal 5’ Phosphate)
B vitamins support numerous metabolic processes in the body. This formula contains the activated forms of select B vitamins to promote optimal use by the body. By using these advanced forms, the body has to work less for utilization and effectiveness is increased. Folinic acid, methylcobalamin (B12) and pyridoxal 5’ phosphate (B6) are known to promote cardiovascular health. Additional B vitamins such as B1, B5, niacin and biotin support many processes allowing this product to work via several mechanisms to increase energy, promote cardiovascular health, decrease stress and improve mood while helping to maintain normal serotonin levels.*


Vitamin C (60 mg)
Vitamin C is a multi-faceted nutrient primarily known for its antioxidant benefits and strong role in immune health. Vitamin C helps support cardiovascular health in a few different ways. Vitamin C protects against LDL peroxidation by scavenging free radicals.*


Vitamin D3 (400 IU)
Vitamin D is a fat-soluble vitamin that is found in some foods and endogenously produced when sunlight strikes the skin and activates vitamin D synthesis. Vitamin D promotes the efficient intestinal absorption of calcium, by supporting the synthesis of calcium-binding proteins to promote normal calcium absorption and retention. Vitamin D also promotes the normal formation of bone and normal bone growth, and bone remodeling by osteoblasts and osteoclasts. Vitamin D deficiency can be caused by factors such as lack of exposure to sunlight, reduced skin synthesis of vitamin D, lower dietary intake, impaired intestinal absorption, and reduced metabolism to active forms of vitamin D by the kidneys, all of which increase with aging. Deficiency has been linked to numerous health concerns and insufficient levels of this vitamin are associated with weak bones and muscle weakness. In addition to promoting strong bones, vitamin D also has other roles in health, including supporting the body’s immune function. Vitamin D has been shown to support normal immune-modulation, and it is thought that supplementation promotes immune health by promoting the body’s normal regulation of T-cell function. 

Frequently Asked Questions about Isotonix® Champion Blend Plus 
Should this product be taken on an empty stomach?
Yes. Maximum absorption occurs when taken on an empty stomach.


I am healthy and athletic. Why should I take Isotonix Champion Blend Plus?
Everyone is vulnerable to the aging process caused by continuous free radicals damage. Athletes tend to be exposed to elevated levels of oxidative stress. Free radicals develop as byproducts during metabolism when calories are processed with oxygen. Athletes inhale 10 to 20 times more oxygen during physical activity over rest periods. The increase in activity creates additional free radicals. In fact, these free radicals are known to limit performance, as free radicals appear to take their toll on muscle tissue. Not only does Isotonix Champion Blend Plus help defend your body against free radicals damage thanks to Pycnogenol, but the inclusion of Instantized Branch Chain Amino Acids can help reduce muscle fatigue, allowing for better workouts.*

What does “Activated” refer to in reference to B-vitamins?
Activated refers to the active forms of vitamins B6, B12 and folic acid. Using forms other than these activated forms requires that the vitamins be enzymatically activated prior to utilization by the body. Not only does this take time and energy within the body, there are circumstances in which this reaction is either slowed or inhibited.


Get Isotonix Champion Blend Plus here 

Tuesday, September 11, 2012

Staying Ahead of Cold and Flu Season


Staying Ahead of Cold and Flu Season


It’s that time of the year again: cold and flu season. Easily one of the more unpleasant experiences to have during the fall, getting sick is surprisingly common and it simply doesn’t need to be. There are plenty of things we can do to prevent coming down with the cold or flu this year.
Washing your hands often and avoiding touching your face, nose, eyes or mouth can help prevent the spread of germs. Even sanitizing doorknobs, handles, keyboards, remotes, keys, and other items you frequently touch can help to keep the cold and flu contained…but what happens when those pathogens are introduced into the body?
Even if you’re prepared for flu season this year, others may not be quite as thoughtful when it comes to flu prevention. The average sneeze travels at approximately 100 miles per hour and carries over 100,000 germs a sneeze. With autumn on its way, now is the time to prime your immune system:
Vitamin A stimulates the production and activity of white blood cells and the endothelial cells that line the body’s interior surfaces which offer primary protection from illness and infection. In its pure form, Vitamin A can be toxic, but stored as Beta Carotene, the body will only convert and use what it needs. The remaining Beta Carotene works as an antioxidant in the body fighting free radicals. Vitamin A must be replaced daily, so make sure this is a part of your everyday regimen.
Vitamin C is well-known for its immunity benefits. Taking Vitamin C regularly can boost immunity, and people who take extra doses of Vitamin C report recovering from colds and the flu much faster than others. Even levels of 200 mg/day increase levels of immunoglobulin, which are proteins that act as disease-fighting antibodies. Vitamin C is often stored as Ascorbic Acid, which also increases the absorption of other vitamins you may be taking.
Vitamin D is best known as a precursor to calcium absorption and bone health, but the Harvard School of Public Health states that vitamin D also obstructs some of the damaging inflammatory response of some white blood cells. This can make a world of difference for those suffering swollen lymph nodes or raw, scratchy throats this cold and flu season. 
Not only can Vitamin E can also help support your body’s healing abilities, but it can also increase immunity response to pathogens. Studies by the Nutritional Immunology Laboratory preformed two separate studies around vitamin E supplementation. His first study found elderly patients who took vitamin E regularly were less likely to come down with colds or upper respiratory infections. The study was repeated again with young men as test subjects who also showed increased immune response.
Selenium is a trace mineral which is reduced into selenoproteins by the body. In this form, it can not only  supports cellular immune response and cell membrane health, but it can also aid the body facilitate antioxidant enzymes. This means selenium can play a substantial role in helping the body fight off pathogens and free radicals.
Regular amounts of zinc can help ensure your T-cells and other immune cells are able to function properly and defend the body. Zinc deficiency or zinc overdose can inhibit your immune response. Meeting your Recommended Daily Allowance (RDA) can help you avoid developing a deficiency of the trace element, zinc. 

All of these can be taken simply by using this here




Thursday, July 19, 2012

How to Choose a Multivitamin


How to Choose a Multivitamin 
from Scientific Affairs

While it’s generally agreed that a balanced diet is the best foundation for health, some studies suggest that to receive the required amounts of all vitamins and minerals we would need to consume approximately 3,000 calories worth of very specific fruit and vegetable combinations on a daily basis. For anyone who is not free to cook—and eat—for the majority of the day, this is not a viable option.

For these reasons among others, it’s no surprise that a study conducted by The Council for Responsible Nutrition shows that a daily multivitamin is the first choice among dietary supplements. Adding to healthy eating with the missing vitamins and minerals not only helps prevent deficiencies related to disease; it also promotes optimal performance in everyday life. As a result, multivitamin supplementation continues to increase, as do the available choices. When it comes to making the right choice, the following points will provide solid guidance.
    MultiVitamin
  • Most multivitamins will contain approximately 100 percent of the RDA recommendations for 20-25 individual nutrients—in general, the most important of these are the B-complex vitamins, Vitamin D and Vitamin E, and these can certainly be present in higher amounts.
  • Biotin is critical for B-complex absorption, but is often included in minimal amounts for reasons of cost—a quality multivitamin will contain 100 percent of the RDA.
  • Zinc is regarded as increasingly important in recent studies, and obtaining the entire RDA from food can be challenging; a quality multivitamin should contain approximately 50 percent of the RDA to make up the difference.
  • Iodine helps to ensure proper thyroid function, which is foundational to proper metabolism—a sound multivitamin formula will contain 100 percent of the RDA.
  • Despite debate about iron supplementation, it is almost certainly advisable for pre-menopausal women; their RDA is set at 18mg, while men require 8mg.
  • Selenium has demonstrated particular potential for men’s health, specifically prostate function, but intake must be moderate, regardless of gender—a balanced formulation will contain 75 to 100 percent of the RDA.
As the last two points suggest, varied vitamin and mineral needs have been shown in certain populations, such as higher amounts of B-complex for athletes, Vitamin D for adults over 65, and other categories based on individual genetics and lifestyle habits. Assessing those needs and taking the next step towards custom nutrition may prove useful for those individuals.

All of the above, however, will definitely prove useful in selecting a good general-purpose multivitamin. In times when many of us find ourselves struggling to reach the top of the food pyramid, this simple measure can deliver a much-needed nutritional boost.

Wednesday, November 02, 2011

Vitamin D, calcium combo may halve melanoma risk some women

 Certain women at risk for developing melanoma, the most severe form of skin cancer, may cut the likelihood in half by taking vitamin D/calcium supplements, a new study suggests.
"It looks like there is some promising evidence for vitamin D and calcium for prevention of melanoma in a high-risk group," said lead researcher Dr. Jean Tang, an assistant professor of dermatology at Stanford University School of Medicine.
The women most at risk of developing the life-threatening cancer are those who have had a previous non-melanoma form of skin cancer, such as basal cell or squamous cell cancer, the researchers said.
Vitamin D and calcium are well-known for their roles in bone growth, but they also affect other cells in the body. Some studies have shown that vitamin D and calcium are associated with lower risk of colon, breast, prostate and other cancers, the researchers said.
Tang speculated that cancer cells lurking in the skin of women who have had a previous skin cancer may be waiting to develop into melanoma. "But if they take calcium and vitamin D that reduces the risk of developing an actual tumor," she said.
As little as 400 international units (IU) of vitamin D daily may be protective, Tang said. The U.S. Institute of Medicine now recommends 600 IU of vitamin D daily, she added.
Calcium has also been shown to reduce tumor growth in patients with colon cancer, Tang said. "So maybe calcium has a role, too," she said. "I can't say whether it was the calcium or the vitamin D that was important."
But the combination seemed to convey a benefit, she added.
Whether these results would be seen in men or young women isn't known, Tang noted. But an earlier study led by Tang found a benefit from vitamin D in reducing the risk of melanoma among older men.
"More studies need to be done, because we want to make sure these results are true in other communities," Tang said.
The report was published in the June 27 online edition of the Journal of Clinical Oncology.
For the study, Tang's team collected data on 36,282 postmenopausal women, 50 to 79 years old, who took part in the Women's Health Initiative study. As part of a test to see if calcium plus vitamin D had any effect on hip fractures or colon cancer, the women were randomly assigned to take supplements or placebo.
The supplements were 1,000 milligrams of calcium and 400 IU of vitamin D daily.
Over about seven years of follow-up, the women taking the supplements who had had previous non-melanoma skin cancer reduced their risk of developing melanoma by 57 percent, compared with similar women not taking the supplements.
The melanoma risk reduction was not seen among women who had not had an earlier non-melanoma skin cancer, the study authors noted.
Overall, only 176 cases of melanoma developed, said the researchers.
In the United States, more than 68,000 cases of melanoma are diagnosed in adults each year, according to the U.S. National Cancer Institute.
Hoping to uncover why vitamin D and/or calcium may be beneficial, Tang said the team next intends to test the compounds directly on cancer cells.
Commenting on the study, Dr. Michael Holick, professor of medicine, physiology and biophysics at Boston University School of Medicine, said a lot of sun exposure early in life increases the risk for non-melanoma skin cancer, but may actually lower the risk of developing melanoma. Sunlight is a source of vitamin D.
"Melanoma is a different story. Being exposed to sunlight, making some vitamin D may very well be protective of melanoma," Holick said. "The thinking is, improving your vitamin D status, whether by supplements or by exposure to sunlight, you are providing your skin cells with a mechanism to prevent them from becoming malignant," he said.

What role calcium may play is unknown, Holick said. "We don't know whether vitamin D can have its effect in the absence of calcium or vice versa; there's rationale for both," he said.
Holick said he thinks the finding would be the same for men and other groups.
People can get their vitamin D from diet, sun exposure and supplements. Fatty fish and fortified dairy products are two dietary sources of vitamin D.
Holick said he recommends that children take 1,000 IU of vitamin D a day and adults, 2,000 IU.

Tuesday, September 13, 2011

Confirmation that vitamin D acts as a protective agent against the advance of colon cancer

www.Worldhealth.net reports
Vitamin D Protects Against Advance of Colon Cancer | Worldhealth.net Anti-Aging News

Confirmation that vitamin D acts as a protective agent against the advance of colon cancer

A study conducted by VHIO researchers confirms that a lack of vitamin D increases the aggressiveness of colon cancer

The indication that vitamin D and its derivatives have a protective effect against various types of cancer is not new. In the field of colon cancer, numerous experimental and epidemiological studies show that vitamin D3 (or cholecalciferol) and some of its derivatives inhibit the growth of cancerous cells. Researchers at the Vall d'Hebron Institute of Oncology (VHIO), in collaboration with the Alberto Sols Institute of Biomedical Research (CSIC-UAB), have confirmed the pivotal role of vitamin D, specifically its receptor (VDR), in slowing down the action of a key protein in the carcinogenic transformation process of colon cancer cells. These results are being published in the journal PLoS One.
This protein, known as beta-catenin, which is normally found in intestinal epithelial cells where it facilitates their cohesion, builds up in large quantities in other areas of the cells when the tumour transformation begins. As a result of these changes, the protein is retained in the cell nucleus, where it facilitate the carcinogenic process, and this is the point at which vitamin D intervenes, or rather, the vitamin D receptor (VDR). "Our study has confirmed the pivotal role of the VDR in controlling the anomalous signal that sparks off the growth and uncontrolled proliferation of colon cells which, in the final instance, ends up causing a tumour to emerge", says Héctor Palmer, the coordinator of this study and head of the VHIO's Stem Cells and Cancer laboratory. He continues, "The stimulation of this receptor suppresses the action of the beta-catenin protein, intercepting the series of events that change the intestinal cell into a malignant tumour cell".
The study was conducted on mice and human colon cancer cells. The mice were used as a model to replicate the initial phases of colon cancer. "These findings show that mice of this kind, which also lack the VDR and hence do not respond to vitamin D, present larger and more aggressive tumours than mice with the VDR", explains Dr. Palmer, and concludes: "The number of tumours is not influenced by the absence of VDR, which would indicate that this factor does not protect against the appearance of the tumour but does intervene in its growth phase, reducing its aggressiveness".
The researchers then analysed the effect of the VDR on human colon cancer cell cultures and observed that the concentration of the altered protein, beta-catenin, increased in cells without the VDR. These findings were repeated in the three types of colon cancer cells studied, and confirmed the results observed in the mice.
In two-thirds of advanced colon cancer tumours there was a lack of VDR in the cancer cells, and this circumstance leads us to believe that this loss may contribute to speeding up the growth of the tumour. The findings of this study confirm this supposition.
Vitamin D: essential in the initial phases of colon cancer
In light of these findings, chronic vitamin D deficiency represents a risk factor in the development of more aggressive colon tumours. Patients in the initial stages of colon cancer, the time when the VDR still has a substantial presence in the cells, could benefit from being treated with vitamin D3. However, this would not be useful in the advanced stages of the disease when the presence of the VDR is very much reduced.
The study data support the development of anti-tumour medicines based on the structure of vitamin D, although their use in patients will require further research in the next few years.
The body not only obtains vitamin D from food, especially milk and fish oils, but also manufactures it from exposure to sunlight. Prolonged exposure is not necessary; just 10 minutes in the sun every day when it is not at its peak is sufficient to stimulate its production. During the summer, when we are more likely to sunbathe, it is important to use the appropriate protective measures against sunburn to avoid future sun damage. Use high-factor solar protection products and do not expose the skin to the sun in the middle of the day to protect against skin cancers.

Please click here for information about an isotonic version of Vitamin D
Isotonix Vitamin D



Friday, June 18, 2010

Supplements beat sun for vitamin D boost: Study

Supplements beat sun for vitamin D boost: Study:

"Adequate vitamin D levels are best achieved by supplements because of the side-effects of UV exposure, says the results of a new computer simulation model from the US."


Supplements beat sun for vitamin D boost:

Study By Stephen Daniells, 18-Jun-2010

Related topics: Research, Vitamins & premixes

Adequate vitamin D levels are best achieved by supplements because of the side-effects of UV exposure, says the results of a new computer simulation model from the US.

We can produce vitamin D in our skin on exposure to sunlight, but the merits of getting the supplement via sunlight or supplements is a source of ongoing debate.

In the US, where over 1.5 million people are diagnosed with skin cancer every year, experts are pushing supplements, claiming recommendations for sun exposure are "highly irresponsible".

Computer science

Scientists from the Memorial Sloan-Kettering Cancer Center in New York and the Norwegian Institute for Air Research in Tromsø used a computer model to determine optimal sun exposure times to produce blood levels of vitamin D3 equivalent to 400 or 1000 IU of vitamin D.

The researcher chose two geographical sites – Miami, FL, and Boston, MA – for their simulation and selected four months – January, April, July, and October.

Data showed that in summer in Boston, people would need between three and eight minutes of sunlight exposure to about 25 per cent of their body surface to synthesise 400 IU of vitamin D. In winter, the simulation indicated that it would be difficult to produce any vitamin D in Boston. No such problems were calculated in Miami, however, with between three and six minutes needed to produce 400 IU at all times of the year.

“There are many limitations to these models, and clearly the estimates are only rough approximations,” said the researchers. “Although it may be tempting to recommend intentional sun exposure for a few minutes several times a week, cutaneous vitamin D synthesis is an intricate process and depends on numerous variables.

“Even in a simplified model such as the one used here, it can be seen to vary considerably by geography, season, and skin type. Furthermore, even if a more accurate and practical model were developed, titrating one’s own exposure to sunlight is difficult, if not impossible.

“Because of these practical difficulties combined with the detrimental side effects of UV exposure, we endorse the IARC assessment that even if it is ultimately demonstrated that increasing vitamin D levels impacts cancer and chronic disease, oral supplements of vitamin D would probably represent the safest way to increase vitamin D status,” concluded the researchers.

D details

Vitamin D refers to two biologically inactive precursors - D3, also known as cholecalciferol, and D2, also known as ergocalciferol. Both D3 and D2 precursors are hydroxylated in the liver and kidneys to form 25- hydroxyvitamin D (25(OH)D), the non-active 'storage' form, and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically active form that is tightly controlled by the body.

An ever growing body of science supports the benefits of maintaining healthy vitamin D levels. In adults, it is said vitamin D deficiency may precipitate or exacerbate osteopenia, osteoporosis, muscle weakness, fractures, common cancers, autoimmune diseases, infectious diseases and cardiovascular diseases. There is also some evidence that the vitamin may reduce the incidence of several types of cancer and type-1 diabetes.

Source: Journal of the American Academy of Dermatology
June 2010, Volume 62, Issue 6, Pages 929.e1-929.e9
“Estimated equivalency of vitamin D production from natural sun exposure versus oral vitamin D supplementation across seasons at two US latitudes”
Authors: V. Terushkin, A. Bender, E.L. Psaty, O. Engelsen, S.Q. Wang, A.C. Halpern

Isotonix Vitamin D with K2

Tuesday, February 09, 2010

Vitamin D Found To Stimulate A Protein That Inhibits The Growth Of Breast Cancer Cells

Vitamin D Found To Stimulate A Protein That Inhibits The Growth Of Breast Cancer Cells

Science News

Vitamin D Found To Stimulate A Protein That Inhibits The Growth Of Breast Cancer Cells

ScienceDaily (Feb. 5, 2009) — Calcitrol, the active form of vitamin D, has been found to induce a tumor suppressing protein that can inhibit the growth of breast cancer cells, according to a study by researcher Sylvia Chistakos, Ph.D., of the UMDNJ-New Jersey Medical School.


Chistakos, a professor of biochemistry, has published extensively on the multiple roles of vitamin D, including inhibition of the growth of malignant cells found in breast cancer. Her current findings on the vitamin D induced protein that inhibits breast cancer growth are published in a recent issue of The Journal of Biological Chemistry.
Previous research had determined that increased serum levels of vitamin D are associated with an improved diagnosis in patients with breast cancer. Prior to the current study, little was known about the factors that determine the effect of calcitrol on inhibiting breast cancer growth, she said.
During the study, Christakos and co-author Puneet Dhawan, Ph.D., examined the protein involved in the action that can reduce the growth of vitamin D in breast cancer cells. “These results provide an important process in which the active form of vitamin D may work to reduce growth of breast cancer cells,” said Christakos. “These studies provide a basis for the design of new anticancer agents that can target the protein as a candidate for breast cancer treatment.”


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Tuesday, December 08, 2009

Vitamin D May Boost Lymphoma Survival

Vitamin D May Boost Lymphoma Survival

Study Shows Low Vitamin D Levels Boost Risk of Non-Hodgkin's Lymphoma
By Kelli Miller Stacy
WebMD Health News
Reviewed by Louise Chang, MD

Dec. 7, 2009 -- Healthy levels of vitamin D may help patients with a certain type of non-Hodgkin's lymphoma live longer.
Researchers at the Mayo Clinic have discovered that patients with diffuse large B-cell lymphoma (DLBCL) and low vitamin D levels are two times more likely to die from the cancer than patients with optimal levels. Deficient vitamin D levels also increased the chances of cancer progression.
"These are some of the strongest findings yet between vitamin D and cancer outcome," Matthew Drake, MD, PhD, an endocrinologist at Mayo Clinic in Rochester, Minn., says in a news release. "While these findings are very provocative, they are preliminary and need to be validated in other studies. However, they raise the issue of whether vitamin D supplementation might aid in treatment for this malignancy."
Non-Hodgkin's lymphoma is a cancer of the white blood cells. DLBCL is the most common type of non-Hodgkin's lymphoma. The fast-growing cancer usually occurs in adults.
The new findings are based on a study of 374 patients who were newly diagnosed with DLBCL. Blood testing showed that half of them had a vitamin D deficiency. Vitamin D deficiency was defined in this study as less than 25 nanogram/milliliter of total vitamin D in the blood.
Those with deficient vitamin D levels were 1.5 times more likely to have the cancer progress, and had a twofold increase in the risk for dying.
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The findings add credence to the growing body of evidence that suggests vitamin D plays an important role in cancer risk and survival. But the American diet usually doesn't provide enough vitamin D. Few foods and drinks naturally contain the vitamin, although some, such as milk, cereals, and certain brands of orange juice, are fortified with it.
The body's greatest supply of vitamin D comes from the sun. The body makes vitamin D after direct exposure to the sun's UV rays. One cause of vitamin D deficiency is limited exposure to sunlight.
"The exact roles that vitamin D might play in the initiation or progression of cancer is unknown, but we do know that the vitamin plays a role in regulation of cell growth and death, among other processes important in limiting cancer," Drake says.
The study team will present their results this week at the 51st annual meeting of the American Society of Hematology in New Orleans.

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