Study: Green Tea; a long- term solution to immune suppressing drugs in autoimmune disease

Posted by Katie McKeown ND on Sat, 08/27/2011

     A new study from the Linus Pauling Institute at Oregon State University has shown that one of the compounds in green tea (EGCG) greatly increases important immune cells that help in the suppression of autoimmune disease.  An estimated 4.5 million Canadians suffer from autoimmune diseases ranging from rheumatoid arthritis to lupus.   The majority of conventional treatments currently available have long-term side effects due to toxicity and greatly suppress the immune system, leaving patients susceptible to a variety of viral and bacterial infections.  The new study shows that 50 mg/kg of green tea derived EGCG has the ability to increase regulatory T cells in mice, which improve the function of the immune system without the negative effects.
     The immune system is typically a tightly controlled process where a variety of immune cells work together to destroy unwanted invaders without damaging normal cells.  This is regulated by a specific group of cells, including regulatory T cells, which turn the attacking cells on and off when an invader is present.  In autoimmune disease, the process becomes dysfunctional and the attacking immune cells begin destroying healthy, normal cells.  The resulting wide-spread inflammation in the body is what causes the symptoms of autoimmune disease.  By affecting the expression of certain transcription factors of DNA, EGCG has been shown to greatly increase the number of regulatory T cells, thus controlling the immune response and reducing inflammation.
     Conventional immune-suppressing drugs are pivotal in the short-term treatment of autoimmune disease and flare-ups and these results do not alter the need for or use of these drugs.  It is the long-term toxicity effects that researchers and clinical practitioners alike are searching for.  This study has given new hope for a long-term treatment for autoimmune disease that has fewer risks and side effects.  In addition, the exciting new research from Oregon State University gives us more evidence that using dietary supplements and plant-based medicine can not only reduce symptoms but also act directly on DNA expression and alter the course of these debilitating diseases.

Immunology Letters
Volume 139, Issues 1-2, 30 September 2011, Pages 7-13


http://www.sciencedirect.com/science/article/pii/S0165247811001258

Supplements beat sun for vitamin D boost: Study

Supplements beat sun for vitamin D boost: Study:

"Adequate vitamin D levels are best achieved by supplements because of the side-effects of UV exposure, says the results of a new computer simulation model from the US."


Supplements beat sun for vitamin D boost:

Study By Stephen Daniells, 18-Jun-2010

Related topics: Research, Vitamins & premixes

Adequate vitamin D levels are best achieved by supplements because of the side-effects of UV exposure, says the results of a new computer simulation model from the US.

We can produce vitamin D in our skin on exposure to sunlight, but the merits of getting the supplement via sunlight or supplements is a source of ongoing debate.

In the US, where over 1.5 million people are diagnosed with skin cancer every year, experts are pushing supplements, claiming recommendations for sun exposure are "highly irresponsible".

Computer science

Scientists from the Memorial Sloan-Kettering Cancer Center in New York and the Norwegian Institute for Air Research in Tromsø used a computer model to determine optimal sun exposure times to produce blood levels of vitamin D3 equivalent to 400 or 1000 IU of vitamin D.

The researcher chose two geographical sites – Miami, FL, and Boston, MA – for their simulation and selected four months – January, April, July, and October.

Data showed that in summer in Boston, people would need between three and eight minutes of sunlight exposure to about 25 per cent of their body surface to synthesise 400 IU of vitamin D. In winter, the simulation indicated that it would be difficult to produce any vitamin D in Boston. No such problems were calculated in Miami, however, with between three and six minutes needed to produce 400 IU at all times of the year.

“There are many limitations to these models, and clearly the estimates are only rough approximations,” said the researchers. “Although it may be tempting to recommend intentional sun exposure for a few minutes several times a week, cutaneous vitamin D synthesis is an intricate process and depends on numerous variables.

“Even in a simplified model such as the one used here, it can be seen to vary considerably by geography, season, and skin type. Furthermore, even if a more accurate and practical model were developed, titrating one’s own exposure to sunlight is difficult, if not impossible.

“Because of these practical difficulties combined with the detrimental side effects of UV exposure, we endorse the IARC assessment that even if it is ultimately demonstrated that increasing vitamin D levels impacts cancer and chronic disease, oral supplements of vitamin D would probably represent the safest way to increase vitamin D status,” concluded the researchers.

D details

Vitamin D refers to two biologically inactive precursors - D3, also known as cholecalciferol, and D2, also known as ergocalciferol. Both D3 and D2 precursors are hydroxylated in the liver and kidneys to form 25- hydroxyvitamin D (25(OH)D), the non-active 'storage' form, and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically active form that is tightly controlled by the body.

An ever growing body of science supports the benefits of maintaining healthy vitamin D levels. In adults, it is said vitamin D deficiency may precipitate or exacerbate osteopenia, osteoporosis, muscle weakness, fractures, common cancers, autoimmune diseases, infectious diseases and cardiovascular diseases. There is also some evidence that the vitamin may reduce the incidence of several types of cancer and type-1 diabetes.

Source: Journal of the American Academy of Dermatology
June 2010, Volume 62, Issue 6, Pages 929.e1-929.e9
“Estimated equivalency of vitamin D production from natural sun exposure versus oral vitamin D supplementation across seasons at two US latitudes”
Authors: V. Terushkin, A. Bender, E.L. Psaty, O. Engelsen, S.Q. Wang, A.C. Halpern

Isotonix Vitamin D with K2