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OPC-3 Pet Health.
Benefits:
° Combats free radicals
° Helps maintain healthy cholesterol levels
° Helps maintain healthy circulation
° Helps maintain joint flexibility
° Helps promote/support cardiovascular health
° Helps support visual health/visual acuity
° Potent free radical scavenger
° Promotes/Supports healthy blood vessel dilation
° Promotes/Supports healthy nitric oxide levels
° Supports healthy blood glucose levels
° Supports healthy platelet activity
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view product demo print this page e-mail this page to a friend Key Ingredients:
Grape Seed Extract
Grape seed extract helps protect cells from free radical damage. Rich in polyphenols, beneficial compounds that have been shown to support normal circulation, grape seed extract can help maintain a healthy circulatory system.
Red Wine Extract
Red wine extract is a potent antioxidant that contains beneficial amounts of resveratrol. Resveratrol can promote normal blood platelet activity and it is believed that it is partially responsible for the cardiovascular health benefits associated with red wine.
Pine Bark Extract
Another strong antioxidant, pine bark extract has been shown to support normal circulation, the immune system and the strength of blood vessel walls.
Bilberry Extract
Bilberry extract is beneficial in promoting strong red blood cells and capillaries, specifically around the eyes and in the retina. Bilberry extract supports the capillaries in the body to help maintain optimal peripheral circulation.
Citrus Bioflavonoids
Citrus bioflavonoids are natural substances found in fruits and vegetables, nuts, and some tree barks. They counter the effects of free radical damage and also promote respiratory health.
Glucosamine
Glucosamine is an aminopolysaccharide (a combination of the amino acid - glutamine and a sugar - glucose). Glucosamine is concentrated in joint cartilage where it is incorporated in longer chains known as glycosaminoglycans and finally into very large structures known as proteoglycans. Glucosamine is naturally produced by the body, and is a key component of cartilage. Glucosamine promotes normal joint function and the normal production of synovial fluid, which lubricates the joints and promotes the normal regeneration of cartilage.
There are numerous European studies showing a clear benefit of glucosamine supplements for promoting joint health. Glucosamine may also support chondrocytes (cartilage cells) in the normal production of healthy new cartilage matrix (both collagen and proteoglycans).
Optimization by Blending
It has been suggested that several antioxidants blended together in moderate amounts may be more effective than high levels of one antioxidant. The blend of antioxidants in PetHealth™ OPC Formula Powder includes grape seed extract, red wine extract, pine bark extract, bilberry extract and citrus bioflavonoids. These antioxidants contain oligomeric proanthocyanidins, or OPCs. Much the same way antioxidants can help optimize a person's health, they can also be beneficial to our dogs and cats. Antioxidants help fight the damage caused by free radicals. They can also help support immune responses and support normal vaccine recognition in dogs and cats. Young animals can benefit tremendously from antioxidants. Antioxidants can help maintain optimum health in your animal's gastrointestinal and cardiovascular systems, liver, kidneys, eyes and immune system. Another important role of pet antioxidants is their ability to support immune-cell function for dogs and cats in their senior years.
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view product demo print this page e-mail this page to a friend What Makes This Product Unique?
A free radical is an atomic structure with an unpaired electron in its outermost shell. These unpaired electrons tend to be highly reactive, resulting in chemical reactions such as oxidation. Because they have one or more unpaired electrons, free radicals are highly unstable. They scavenge the body to grab or donate electrons, causing damage to cells, proteins and DNA. Free radicals are naturally occurring; however, air pollution, stress, cigarette smoke and heavy exercising all contribute to the creation of harmful free radicals. Free radicals can cause oxidative stress. Normally the animal’s body is able to protect itself from the damaging effects of free radicals, but if antioxidants are unavailable, or free radical production becomes excessive, oxidative stress can occur.
Antioxidants are natural cell protectors, neutralizing free radicals by pairing an electron to the outermost shell of radical oxygen molecules, rendering them harmless. Antioxidants are nutrients such as vitamins, minerals and enzymes that are capable of counteracting the damaging, but normal, effects of the physiological process of oxidation in bodily tissues. Antioxidants work in two ways, chain breaking and prevention. A chain-breaking antioxidant such as vitamins A, C and E, stabilize free radicals or cause them to decay into harmless atomic structures. A preventative antioxidant prevents the oxidation process by scavenging free radicals.
PetHealth™ OPC is a food supplement made from a combination of bilberry, grape seed, red wine, pine bark extracts, citrus extract bioflavonoids, and glucosamine, designed to promote healthy joints and provide a strong antioxidant defense. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to your pet’s body. Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. PetHealth OPC Formula with Glucosamine offers a unique, great-tasting powder that is sprinkled over your pet’s regular food. It represents the latest technology available today in naturally based pet food supplements. PetHealth OPC Formula is available in a tasty beef flavor that your pets will love - and youll love knowing that youre doing all you can to help your pets stay healthy and live long, healthy lives.
Pets face many of the same issues as humans. Many pet foods are over processed and have little nutritive value. Dogs and cats breathe in the same pollution as we do, inhaling harmful free radicals. Potent antioxidants like OPCs help to strengthen your pet’s free radical defenses. Antioxidants promote cardiovascular health, support healthy visual acuity, promote healthy blood vessel dilation and promote healthy platelet activity.
Your Pets and Joint Health
As pets become older, antioxidants become even more important in the fight against free radicals and their associated effects on cells in joints and other tissues. All animals are at risk for declining joint health. Many factors can affect joint health and the integrity of cartilage, including diet, genetic make-up and activity levels. The cold wintery months can also contribute to a decline in joint comfort. Each animals genetic code, for example, can influence the thickness and durability of its cartilage and its overall joint health. Proper nutrition, especially antioxidant supplementation, is critical in maintaining healthy joints. Glucosamine has been shown to promote the retention and normal regeneration of cartilage, support normal movement and flexibility of joints and promote joint comfort.
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view product demo print this page e-mail this page to a friend Frequently Asked Questions
What Are OPCs?
OPCs, or oligomeric proanthocyanidins, can help reduce free radical damage, support the strength and normal repair of connective tissue, and can support proper enzyme activity. OPCs can also help maintain normal histamine levels. Not limited to being just strong antioxidants, OPCs are also crucial in their role in supporting the circulatory system.
What Are Antioxidants, and Why Should I Give Them To My Pets?
Antioxidants are naturally occurring nutrients that help maintain optimum health by protecting against free radicals. Antioxidants are found in the body naturally as well as in many plants. Even cells that function normally generate large amounts of oxygen free radicals. Free radicals have an unpaired electron, making many of them reactive and destructive. When free radicals roam freely throughout the body unregulated by antioxidants, they can attack various healthy cell structures, including cell membranes, proteins, RNA and DNA.
Certain factors in everyday life encourage an increase in the formation of free radicals for humans and pets alike. These factors include the air we breathe, the water we drink, and the food we eat. Each one of these necessities can contain harmful reactants. We need a "neutralizer" in our body to rid our system of these harmful reactants and a strong and effective antioxidant is the best way to fight free radicals.
It is becoming increasingly apparent to veterinarians that antioxidant supplementation could very well provide optimal health support for dogs and cats in a manner similar to that experienced by humans. Both pets and their owners could benefit from a "neutralizer" operating in their systems that fight free radicals. A strong antioxidant is the best way to fight free radicals.
What is a bioflavonoid?
Bioflavonoids are complex organic plant compounds. Plants and fruits differ in colors based on the specific bioflavonoids they contain. An increasing number of clinical studies have shown how bioflavonoids support health. Bioflavonoids and OPCs play a key role in supporting cardiovascular health and maintaining vascular integrity. Bioflavonoids have been shown to support healthy circulation and cell vitality. Normal collagen renewal is promoted, which supports firmness of the skin, joint cartilage and connective tissue.
What is the history of OPCs?
In 1534, French explorer Jacques Cartier was leading an expedition up the St. Lawrence River. Trapped by bad weather, Cartier and his crew were forced to survive on a ration of salted meat and biscuits. Cartier's crew began to suffer from severe deficiency of vitamin C and showed symptoms of scurvy. Many crewmembers died before the surviving members encountered a friendly Native American who saved most of their lives. He told them to make a tea from the bark and needles of the pine tree to cure their malady. They complied and, as a result, Cartier and many crewmembers survived.
Some 400 years later, Professor Jacques Masquelier of the University of Bordeaux, France, read a book by Cartier detailing their expedition. He concluded that pine bark not only contained some vitamin C, but obviously was a good source of bioflavonoids, whose effects are similar to those of vitamin C. Further studies and research revealed that the pine bark contained an array of proanthocyanidins complexes. These compounds were also found in a variety of plants, including grape seeds, cranberries, peanut skin, lemon tree bark and citrus rinds. Masquelier termed the active ingredients of the pine bark "pycnogenols", which today are referred to in the scientific community as oligomeric proanthocyanidins, or OPCs.
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view product demo print this page e-mail this page to a friend Click here to view product label
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view product demo print this page e-mail this page to a friend Benefits:
° Combats free radicals
° Helps maintain healthy cholesterol levels
° Helps maintain healthy circulation
° Helps maintain joint flexibility
° Helps promote/support cardiovascular health
° Helps support visual health/visual acuity
° Potent free radical scavenger
° Promotes/Supports healthy blood vessel dilation
° Promotes/Supports healthy nitric oxide levels
° Supports healthy blood glucose levels
° Supports healthy platelet activity
Key Ingredients:
Grape Seed Extract
Grape seed extract helps protect cells from free radical damage. Rich in polyphenols, beneficial compounds that have been shown to support normal circulation, grape seed extract can help maintain a healthy circulatory system.
Red Wine Extract
Red wine extract is a potent antioxidant that contains beneficial amounts of resveratrol. Resveratrol can promote normal blood platelet activity and it is believed that it is partially responsible for the cardiovascular health benefits associated with red wine.
Pine Bark Extract
Another strong antioxidant, pine bark extract has been shown to support normal circulation, the immune system and the strength of blood vessel walls.
Bilberry Extract
Bilberry extract is beneficial in promoting strong red blood cells and capillaries, specifically around the eyes and in the retina. Bilberry extract supports the capillaries in the body to help maintain optimal peripheral circulation.
Citrus Bioflavonoids
Citrus bioflavonoids are natural substances found in fruits and vegetables, nuts, and some tree barks. They counter the effects of free radical damage and also promote respiratory health.
Glucosamine
Glucosamine is an aminopolysaccharide (a combination of the amino acid - glutamine and a sugar - glucose). Glucosamine is concentrated in joint cartilage where it is incorporated in longer chains known as glycosaminoglycans and finally into very large structures known as proteoglycans. Glucosamine is naturally produced by the body, and is a key component of cartilage. Glucosamine promotes normal joint function and the normal production of synovial fluid, which lubricates the joints and promotes the normal regeneration of cartilage.
There are numerous European studies showing a clear benefit of glucosamine supplements for promoting joint health. Glucosamine may also support chondrocytes (cartilage cells) in the normal production of healthy new cartilage matrix (both collagen and proteoglycans).
Optimization by Blending
It has been suggested that several antioxidants blended together in moderate amounts may be more effective than high levels of one antioxidant. The blend of antioxidants in PetHealth™ OPC Formula Powder includes grape seed extract, red wine extract, pine bark extract, bilberry extract and citrus bioflavonoids. These antioxidants contain oligomeric proanthocyanidins, or OPCs. Much the same way antioxidants can help optimize a person's health, they can also be beneficial to our dogs and cats. Antioxidants help fight the damage caused by free radicals. They can also help support immune responses and support normal vaccine recognition in dogs and cats. Young animals can benefit tremendously from antioxidants. Antioxidants can help maintain optimum health in your animal's gastrointestinal and cardiovascular systems, liver, kidneys, eyes and immune system. Another important role of pet antioxidants is their ability to support immune-cell function for dogs and cats in their senior years.
What Makes This Product Unique?
A free radical is an atomic structure with an unpaired electron in its outermost shell. These unpaired electrons tend to be highly reactive, resulting in chemical reactions such as oxidation. Because they have one or more unpaired electrons, free radicals are highly unstable. They scavenge the body to grab or donate electrons, causing damage to cells, proteins and DNA. Free radicals are naturally occurring; however, air pollution, stress, cigarette smoke and heavy exercising all contribute to the creation of harmful free radicals. Free radicals can cause oxidative stress. Normally the animal’s body is able to protect itself from the damaging effects of free radicals, but if antioxidants are unavailable, or free radical production becomes excessive, oxidative stress can occur.
Antioxidants are natural cell protectors, neutralizing free radicals by pairing an electron to the outermost shell of radical oxygen molecules, rendering them harmless. Antioxidants are nutrients such as vitamins, minerals and enzymes that are capable of counteracting the damaging, but normal, effects of the physiological process of oxidation in bodily tissues. Antioxidants work in two ways, chain breaking and prevention. A chain-breaking antioxidant such as vitamins A, C and E, stabilize free radicals or cause them to decay into harmless atomic structures. A preventative antioxidant prevents the oxidation process by scavenging free radicals.
PetHealth™ OPC is a food supplement made from a combination of bilberry, grape seed, red wine, pine bark extracts, citrus extract bioflavonoids, and glucosamine, designed to promote healthy joints and provide a strong antioxidant defense. Oligomeric proanthocyanidins (OPCs) are bioflavonoids (complex organic plant compounds) found in fruits, vegetables and certain tree barks that provide exceptional nutritional benefits to your pet’s body. Studies have shown OPCs to be up to 20 times more powerful than vitamin C and 50 times more powerful than vitamin E in neutralizing free radicals. PetHealth OPC Formula with Glucosamine offers a unique, great-tasting powder that is sprinkled over your pet’s regular food. It represents the latest technology available today in naturally based pet food supplements. PetHealth OPC Formula is available in a tasty beef flavor that your pets will love - and youll love knowing that youre doing all you can to help your pets stay healthy and live long, healthy lives.
Pets face many of the same issues as humans. Many pet foods are over processed and have little nutritive value. Dogs and cats breathe in the same pollution as we do, inhaling harmful free radicals. Potent antioxidants like OPCs help to strengthen your pet’s free radical defenses. Antioxidants promote cardiovascular health, support healthy visual acuity, promote healthy blood vessel dilation and promote healthy platelet activity.
Your Pets and Joint Health
As pets become older, antioxidants become even more important in the fight against free radicals and their associated effects on cells in joints and other tissues. All animals are at risk for declining joint health. Many factors can affect joint health and the integrity of cartilage, including diet, genetic make-up and activity levels. The cold wintery months can also contribute to a decline in joint comfort. Each animals genetic code, for example, can influence the thickness and durability of its cartilage and its overall joint health. Proper nutrition, especially antioxidant supplementation, is critical in maintaining healthy joints. Glucosamine has been shown to promote the retention and normal regeneration of cartilage, support normal movement and flexibility of joints and promote joint comfort.
Frequently Asked Questions
What Are OPCs?
OPCs, or oligomeric proanthocyanidins, can help reduce free radical damage, support the strength and normal repair of connective tissue, and can support proper enzyme activity. OPCs can also help maintain normal histamine levels. Not limited to being just strong antioxidants, OPCs are also crucial in their role in supporting the circulatory system.
What Are Antioxidants, and Why Should I Give Them To My Pets?
Antioxidants are naturally occurring nutrients that help maintain optimum health by protecting against free radicals. Antioxidants are found in the body naturally as well as in many plants. Even cells that function normally generate large amounts of oxygen free radicals. Free radicals have an unpaired electron, making many of them reactive and destructive. When free radicals roam freely throughout the body unregulated by antioxidants, they can attack various healthy cell structures, including cell membranes, proteins, RNA and DNA.
Certain factors in everyday life encourage an increase in the formation of free radicals for humans and pets alike. These factors include the air we breathe, the water we drink, and the food we eat. Each one of these necessities can contain harmful reactants. We need a "neutralizer" in our body to rid our system of these harmful reactants and a strong and effective antioxidant is the best way to fight free radicals.
It is becoming increasingly apparent to veterinarians that antioxidant supplementation could very well provide optimal health support for dogs and cats in a manner similar to that experienced by humans. Both pets and their owners could benefit from a "neutralizer" operating in their systems that fight free radicals. A strong antioxidant is the best way to fight free radicals.
What is a bioflavonoid?
Bioflavonoids are complex organic plant compounds. Plants and fruits differ in colors based on the specific bioflavonoids they contain. An increasing number of clinical studies have shown how bioflavonoids support health. Bioflavonoids and OPCs play a key role in supporting cardiovascular health and maintaining vascular integrity. Bioflavonoids have been shown to support healthy circulation and cell vitality. Normal collagen renewal is promoted, which supports firmness of the skin, joint cartilage and connective tissue.
What is the history of OPCs?
In 1534, French explorer Jacques Cartier was leading an expedition up the St. Lawrence River. Trapped by bad weather, Cartier and his crew were forced to survive on a ration of salted meat and biscuits. Cartier's crew began to suffer from severe deficiency of vitamin C and showed symptoms of scurvy. Many crewmembers died before the surviving members encountered a friendly Native American who saved most of their lives. He told them to make a tea from the bark and needles of the pine tree to cure their malady. They complied and, as a result, Cartier and many crewmembers survived.
Some 400 years later, Professor Jacques Masquelier of the University of Bordeaux, France, read a book by Cartier detailing their expedition. He concluded that pine bark not only contained some vitamin C, but obviously was a good source of bioflavonoids, whose effects are similar to those of vitamin C. Further studies and research revealed that the pine bark contained an array of proanthocyanidins complexes. These compounds were also found in a variety of plants, including grape seeds, cranberries, peanut skin, lemon tree bark and citrus rinds. Masquelier termed the active ingredients of the pine bark "pycnogenols", which today are referred to in the scientific community as oligomeric proanthocyanidins, or OPCs.
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Friday, December 25, 2009
Saturday, December 19, 2009
Market America Motives® Lustrafy Mascara
Lustrafy Mascara is considered #1 according to all the reviews on www.Buzzillions.com
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Friday, December 18, 2009
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Tuesday, December 15, 2009
www.CustomizeME.com Get Paid To Shop
SEARCH, SHOP, SAVE AND SHARE
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Use www.CustomizeME.com to find great deals on all the products you want from all the stores you love and trust. Earn 2% cash back on purchases and a half percent cash on the purchases of others you refer. Start earning now at www.CustomizeME.com!
Tuesday, December 08, 2009
Vitamin D May Boost Lymphoma Survival
Vitamin D May Boost Lymphoma Survival
Study Shows Low Vitamin D Levels Boost Risk of Non-Hodgkin's Lymphoma
By Kelli Miller Stacy
WebMD Health News
Reviewed by Louise Chang, MD
Dec. 7, 2009 -- Healthy levels of vitamin D may help patients with a certain type of non-Hodgkin's lymphoma live longer.
Researchers at the Mayo Clinic have discovered that patients with diffuse large B-cell lymphoma (DLBCL) and low vitamin D levels are two times more likely to die from the cancer than patients with optimal levels. Deficient vitamin D levels also increased the chances of cancer progression.
"These are some of the strongest findings yet between vitamin D and cancer outcome," Matthew Drake, MD, PhD, an endocrinologist at Mayo Clinic in Rochester, Minn., says in a news release. "While these findings are very provocative, they are preliminary and need to be validated in other studies. However, they raise the issue of whether vitamin D supplementation might aid in treatment for this malignancy."
Non-Hodgkin's lymphoma is a cancer of the white blood cells. DLBCL is the most common type of non-Hodgkin's lymphoma. The fast-growing cancer usually occurs in adults.
The new findings are based on a study of 374 patients who were newly diagnosed with DLBCL. Blood testing showed that half of them had a vitamin D deficiency. Vitamin D deficiency was defined in this study as less than 25 nanogram/milliliter of total vitamin D in the blood.
Those with deficient vitamin D levels were 1.5 times more likely to have the cancer progress, and had a twofold increase in the risk for dying.
The findings add credence to the growing body of evidence that suggests vitamin D plays an important role in cancer risk and survival. But the American diet usually doesn't provide enough vitamin D. Few foods and drinks naturally contain the vitamin, although some, such as milk, cereals, and certain brands of orange juice, are fortified with it.
The body's greatest supply of vitamin D comes from the sun. The body makes vitamin D after direct exposure to the sun's UV rays. One cause of vitamin D deficiency is limited exposure to sunlight.
"The exact roles that vitamin D might play in the initiation or progression of cancer is unknown, but we do know that the vitamin plays a role in regulation of cell growth and death, among other processes important in limiting cancer," Drake says.
The study team will present their results this week at the 51st annual meeting of the American Society of Hematology in New Orleans.
For a good vitamin D product
visit --- www.CustomizeME.com
Study Shows Low Vitamin D Levels Boost Risk of Non-Hodgkin's Lymphoma
By Kelli Miller Stacy
WebMD Health News
Reviewed by Louise Chang, MD
Dec. 7, 2009 -- Healthy levels of vitamin D may help patients with a certain type of non-Hodgkin's lymphoma live longer.Researchers at the Mayo Clinic have discovered that patients with diffuse large B-cell lymphoma (DLBCL) and low vitamin D levels are two times more likely to die from the cancer than patients with optimal levels. Deficient vitamin D levels also increased the chances of cancer progression.
"These are some of the strongest findings yet between vitamin D and cancer outcome," Matthew Drake, MD, PhD, an endocrinologist at Mayo Clinic in Rochester, Minn., says in a news release. "While these findings are very provocative, they are preliminary and need to be validated in other studies. However, they raise the issue of whether vitamin D supplementation might aid in treatment for this malignancy."
Non-Hodgkin's lymphoma is a cancer of the white blood cells. DLBCL is the most common type of non-Hodgkin's lymphoma. The fast-growing cancer usually occurs in adults.
The new findings are based on a study of 374 patients who were newly diagnosed with DLBCL. Blood testing showed that half of them had a vitamin D deficiency. Vitamin D deficiency was defined in this study as less than 25 nanogram/milliliter of total vitamin D in the blood.
Those with deficient vitamin D levels were 1.5 times more likely to have the cancer progress, and had a twofold increase in the risk for dying.
 |
| Isotonix Vitamin D with K2 |
The body's greatest supply of vitamin D comes from the sun. The body makes vitamin D after direct exposure to the sun's UV rays. One cause of vitamin D deficiency is limited exposure to sunlight.
"The exact roles that vitamin D might play in the initiation or progression of cancer is unknown, but we do know that the vitamin plays a role in regulation of cell growth and death, among other processes important in limiting cancer," Drake says.
The study team will present their results this week at the 51st annual meeting of the American Society of Hematology in New Orleans.
For a good vitamin D product
visit --- www.CustomizeME.com
Monday, November 30, 2009
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Thursday, November 19, 2009
Probiotics intake beneficial against infections in kids: study
Probiotics intake beneficial against infections in kids: study
Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: A randomized, double-blind, placebo-controlled trial☆
Received 17 July 2009; accepted 28 September 2009. published online 05 October 2009.
Corrected Proof
Corrected Proof
Summary
Background & aims
The aim of our study was to investigate the role of Lactobacillus GG (LGG) in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers.
Methods
We conducted a randomized, double-blind, placebo-controlled trial in 281 children who attend day care centers. They were randomly allocated to receive LGG at a dose of 109 colony-forming units in 100
ml of a fermented milk product (LGG group, n=139) or placebo that was the same post-pasteurized fermented milk product without LGG (placebo group, n=142) during the 3-month intervention period.
ml of a fermented milk product (LGG group, n=139) or placebo that was the same post-pasteurized fermented milk product without LGG (placebo group, n=142) during the 3-month intervention period.Results
Compared to the placebo group, children in the LGG group had a significantly reduced risk of upper respiratory tract infections (RR 0.66, 95% CI 0.52 to 0.82, NNT 5, 95% CI 4 to 10), a reduced risk of respiratory tract infections lasting longer than 3 days (RR 0.57, 95% CI 0.41 to 0.78, NNT 5, 95% CI 4 to 11), and a significantly lower number of days with respiratory symptoms (p<0.001). There was no risk reduction in regard to lower respiratory tract infections (RR 0.82, 95% CI 0.24 to 2.76). Compared with the placebo group, children in the LGG group had no significant reduction in the risk of gastrointestinal infections (RR 0.63, 95% CI 0.38 to 1.06), vomiting episodes (RR 0.60, 95% CI 0.29 to 1.24), and diarrheal episodes (RR 0.63, 95% CI 0.35 to 1.11) as well as no reduction in the number of days with gastrointestinal symptoms (p=0.063).
<0.001). There was no risk reduction in regard to lower respiratory tract infections (RR 0.82, 95% CI 0.24 to 2.76). Compared with the placebo group, children in the LGG group had no significant reduction in the risk of gastrointestinal infections (RR 0.63, 95% CI 0.38 to 1.06), vomiting episodes (RR 0.60, 95% CI 0.29 to 1.24), and diarrheal episodes (RR 0.63, 95% CI 0.35 to 1.11) as well as no reduction in the number of days with gastrointestinal symptoms (p=0.063).Conclusion
LGG administration can be recommended as a valid measure for decreasing the risk of upper respiratory tract infections in children attending day care centers.
Abbreviations: LGG, Lactobacillus GG, RR, relative risk, CI, 95% confidence interval, NNT, number needed to treat
a Referral Center for Pediatric Gastroenterology and Nutrition, Children's Hospital Zagreb, Klaićeva 16, Zagreb, Croatia
b Department for Otorinolaringology, General Hospital Dr. Ivo Pedišić, J.J. Strossmayera 59, Sisak, Croatia
c 2nd Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland
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Tuesday, November 17, 2009
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Tuesday, October 27, 2009
Vitamin D Research
 |
| Add caption |
Supplements of the sunshine vitamin may improve insulin resistance and sensitivity, both of which are risk factors for diabetes, says a new study from New Zealand.
At least one in five U.S. children aged 1 to 11 don't get enough vitamin D and could be at risk for a variety of health problems including weak bones, the most recent national analysis suggests.
Thursday, October 22, 2009
McDonald's Accused of Selling Cancer-Causing Chicken
McDonald’s Accused of Selling Cancer-Causing Chicken (Update3)
The browning of meat and poultry create Advanced Glycation End Products ( AGEs ) in the body.
Market America's Prime AGE Defense Formula helps maintain a normal level of AGEs in the body and supports the body’s normal ability to remove AGEs.
By Thom Weidlich
Oct. 21 (Bloomberg) -- McDonald’s Corp.,Burger King Holdings Inc. and Friendly Ice Cream Corp. were accused in a lawsuit of selling chicken they know contains a chemical that can cause cancer even in small amounts.
McDonald’s, the world’s biggest restaurant company, and the other dining chains were sued today in state court in Hartford, Connecticut. The complaint, filed by Washington-based Cancer Project on behalf of two Connecticut residents, seeks class- action, or group, status on behalf of people who bought or ate the grilled chicken from October 2006 to this month.
“We’re not looking to have them stop selling the product,” Daniel Kinburn, a lawyer with the Cancer Project, said in a phone interview. “The product is a legal though dangerous product that should be sold with a warning, like a chainsaw.”
A similar suit against seven restaurant chains in 2006 and another against Yum! Brands Inc.’s KFC unit last month were filed in California. That state listed the chemical, PhIP, which forms during the grilling process, as a known carcinogen in 1994, according to the complaint.
“At McDonald’s we have some of the highest food safety standards in the industry,” Cynthia Goody, director of nutrition at the company, said in an e-mailed statement. “There is no scientific evidence to suggest the small amount of PhIP that can be created as a byproduct of cooking methods humans have employed for thousands of years poses a health risk.”
‘No Merit’
“Burger King Corp. believes the lawsuit filed in Connecticut by the Washington-based Cancer Project has no merit,” the company said in an e-mailed statement. “The compound referred to in the lawsuit, PhIP, is a naturally occurring by-product of the normal cooking process and is produced when any poultry, meat or fish is broiled, fried or grilled. There is no evidence that the small amount of PhIP contained in food poses a significant health risk.”
“We ensure that we meet or exceed all guidelines and regulations for food preparation and safety,” Maura Tobias, a spokeswoman for Friendly’s, said in an e-mailed statement. “Very low levels of PhIP occur naturally when any meat is grilled, including cooking at home.”
The companies “concealed the presence of a known carcinogen in their grilled-chicken products to retain profits that would be lost, in whole or in part, as a result of properly informed consumers choosing other food products,” the residents said in their complaint.
California Settlement
Burger King settled the first suit and agreed to post warnings in its California restaurants, Kinburn said. The company wouldn’t agree to a national settlement, he said. The case is otherwise unresolved, he said. KFC was sued separately because it added grilled chicken to its menu in April, he said.
“Dozens of studies show even relatively small amounts of PhIP can increase the risk of various forms of cancer,” Kinburn said.
The residents who filed the Connecticut suit, Rebecca Delio, of Stamford, and Mary-Ann Ellison, of Meriden, want the court to force the companies to include warnings in their restaurants, menus and advertisements that the food is known to contain chemicals that cause cancer.
Delio ate grilled chicken from one of the three companies’ restaurants once a week, and Ellison four times a month at a McDonald’s in Wallingford, according to the complaint. Both stopped buying the grilled chicken about a year ago when they learned of the cancer risk, they said in the complaint.
‘A Possibility’
Delio, 66, was diagnosed with breast cancer a year ago, she said in a phone interview. She can’t blame her diagnosis on eating grilled chicken, she said. “It’s a possibility,” she said, adding that cancer runs in her family.
“I happen to like grilled chicken,” Delio said. “I checked it out on the Internet, and I learned that this is true, that grilled stuff is really no good for you.”
Ellison’s boyfriend was diagnosed with colon cancer, Kinburn said. He has other medical issues and the couple turned to grilled-chicken salads for what they thought would be healthful meals, the lawyer said.
Ellison doesn’t have cancer, Kinburn said. She didn’t immediately return a call for comment.
“Outside of the scientific oncology community and upper management of national restaurant chains, few people are aware of the presence of PhIP in grilled, flame-grilled or barbequed chicken,” Delio and Ellison said in their complaint.
Poultry Industry
The fast-food companies and the poultry industry mislead consumers into thinking that grilled chicken is healthier than beef, they said.
Oak Brook, Illinois-based McDonald’s offerings include Premium Grilled Chicken Classic Sandwich and Premium Bacon Ranch Salad With Grilled Chicken. Miami-based Burger King, the largest U.S. hamburger seller after McDonald’s, sells Tendergrill Chicken Sandwich and Tendergrill Chicken Garden Salad.
Wilbraham, Massachusetts-based Friendly’s is owned by the private-equity firm Sun Capital Partners Inc. in Boca Raton, Florida. The restaurant chain sells Grilled Chicken Deluxe Sandwich, BBQ Chicken Platter and Cheddar Jack Chicken with Grilled Chicken.
Rick Maynard, a spokesman for KFC, said when the California suit was filed against it that its grilled chicken meets all regulations for food safety. California’s attorney general determined in 2006 that the state’s Proposition 65 doesn’t require a warning for PhIP in chicken, Maynard said.
Yum Brands! is based in Louisville, Kentucky.
McDonald’s fell 59 cents to $58.33 in New York Stock Exchange composite trading at 4:15 p.m. Burger King rose 17 cents to $18.18.
The case is Delio v. McDonald’s Corp., Connecticut Superior Court (Hartford).
To contact the reporter on this story: Thom Weidlich in New York at tweidlich@bloomberg.net.
Last Updated: October 21, 2009 17:34 EDTThe browning of meat and poultry create Advanced Glycation End Products ( AGEs ) in the body.
Market America's Prime AGE Defense Formula helps maintain a normal level of AGEs in the body and supports the body’s normal ability to remove AGEs.
Primary Benefits of Prime™ AGE Defense Formula*:
· Helps to maintain a normal level of Advanced Glycation End Products (AGEs) in the body
· Supports the body’s normal ability to remove Advanced Glycation End Products (AGEs)
· Helps to promote healthy aging
· Promotes healthy metabolism of glucose
· Helps to maintain normal blood glucose levels
· Supports a healthy endocrine system
· Helps maintain a healthy pancreas
· Supports the normal function of the pancreas
· Promotes normal circulation to the extremities
· Promotes healthy, elastic arteries
· Supports healthy collagen and elastin
· Inhibits premature aging of the skin
Friday, February 27, 2009
Monday, March 31, 2008
Barbara Walters Live to 150 Special: Resveratrol
http://abcnews.go.com/Health/Longevity/Story?id=4543291&page=3
Resveratrol
David Sinclair, co-founder of Sirtris Pharmaceuticals in Cambridge, Mass., has found a protein in our bodies that could be the key to resetting our biological clocks.
He made the discovery by randomly testing tens of thousands of cells, searching for the chemical that would activate that protein -- resveratrol.
"We found them by accident. We stumbled upon this molecule from red wine. And when I looked at the computer, [I asked,] what is this resveratrol?" said Sinclair. "And [when I] found that it was in red wine … [well,] I almost fell off my chair. Because of course we have all heard that red wine is good for you."
But to see the benefits, you would need to drink about 1,000 bottles a day. Since that was not the solution, Sinclair went back to the lab and found a way to make resveratrol a thousand times more potent.
"What we have discovered is that resveratrol works on a gene, which is called SIR T1, and this is a gene, which controls the aging process," said Sinclair. "Resveratrol seeks out that gene and switches it on."
Sinclair tested these high doses of resveratrol on mice. When compared on treadmills side by side, the mouse, when given this intensified form of resveratrol, ran twice as far as the mouse who was not fed the molecule. The supplement had major health benefits as well.
"They were eating a high fat diet, a fatty diet, and they lived just as long as a lean, healthy mouse. They didn't get heart disease, cancer, even osteoporosis, and they lived 30 percent longer," he said.
Humans have the same exact gene that is activated by resveratrol, so Sinclair believed it could have similar benefits in people.
Realizing the blockbuster potential for his new pill based on an intensified and improved form of resveratrol, Sinclair teamed up with biotech entrepreneur Chris Westphal and together they raised more than $100 million for further research.
"I think we've passed the turning point in our understanding of the aging process, " said Sinclair.
"We think that we can increase healthy life span. So if you're in your 80s, you'll be behaving as if you were in your 50s."
In the first human trial, a form of resveratrol called SRT501 successfully treated type II diabetes, one of the major diseases of aging.
"The major killers of Western society are exactly the diseases that should be able to be treated with the drugs we're developing," Sinclair states.
He and Westphal plan to get regulatory approval from the Food and Drug Administration within five years.
David Sinclair, co-founder of Sirtris Pharmaceuticals in Cambridge, Mass., has found a protein in our bodies that could be the key to resetting our biological clocks.
He made the discovery by randomly testing tens of thousands of cells, searching for the chemical that would activate that protein -- resveratrol.
"We found them by accident. We stumbled upon this molecule from red wine. And when I looked at the computer, [I asked,] what is this resveratrol?" said Sinclair. "And [when I] found that it was in red wine … [well,] I almost fell off my chair. Because of course we have all heard that red wine is good for you."
But to see the benefits, you would need to drink about 1,000 bottles a day. Since that was not the solution, Sinclair went back to the lab and found a way to make resveratrol a thousand times more potent.
"What we have discovered is that resveratrol works on a gene, which is called SIR T1, and this is a gene, which controls the aging process," said Sinclair. "Resveratrol seeks out that gene and switches it on."
Sinclair tested these high doses of resveratrol on mice. When compared on treadmills side by side, the mouse, when given this intensified form of resveratrol, ran twice as far as the mouse who was not fed the molecule. The supplement had major health benefits as well.
"They were eating a high fat diet, a fatty diet, and they lived just as long as a lean, healthy mouse. They didn't get heart disease, cancer, even osteoporosis, and they lived 30 percent longer," he said.
Humans have the same exact gene that is activated by resveratrol, so Sinclair believed it could have similar benefits in people.
Realizing the blockbuster potential for his new pill based on an intensified and improved form of resveratrol, Sinclair teamed up with biotech entrepreneur Chris Westphal and together they raised more than $100 million for further research.
"I think we've passed the turning point in our understanding of the aging process, " said Sinclair.
"We think that we can increase healthy life span. So if you're in your 80s, you'll be behaving as if you were in your 50s."
In the first human trial, a form of resveratrol called SRT501 successfully treated type II diabetes, one of the major diseases of aging.
"The major killers of Western society are exactly the diseases that should be able to be treated with the drugs we're developing," Sinclair states.
He and Westphal plan to get regulatory approval from the Food and Drug Administration within five years.
Market America has it now... http://www.marketamerica.com/customizeme/index.cfm?action=shopping.uoProduct&storeID=8&prodID=13061
Tuesday, June 05, 2007
New Study: Pycnogenol® Reduces Heart Failure
05/16/2007
New Study: Pycnogenol® Reduces Heart Failure
May 16, 2007 – GENEVA, Switzerland – A study to be published in an upcoming edition of the journal of Cardiovascular Toxicology reveals Pycnogenol®, natural pine bark extract from the French maritime pine tree, helps prevent damage that high blood pressure causes to the heart. The study demonstrates Pycnogenol® counteracts the “wearing out” of the heart, which may aid the five million Americans living with heart failure. Previous studies have shown Pycnogenol® supplementation to be associated with improved cardiovascular health, such as cholesterol reduction, blood pressure control and prevention of thrombosis.
In hypertension, the over-worked heart gradually wears out, resulting in the weakening of the heart muscle and increasing of heart chamber volume. This process (known as cardiac remodeling) may eventually cause heart failure when the heart insufficiently supplies the body with oxygenated blood. The study showed that Pycnogenol® prevents the heart from getting worn out during hypertension. Cardiac chamber walls showed a significantly higher rate of collagen connective tissues than control groups.
“Alternative treatments such as Pycnogenol® are crucial components in the fight against heart disease,” said Dr. Ronald Watson, professor in the Department of Nutritional Sciences at the University of Arizona and a lead researcher of the study. “The effectiveness of Pycnogenol® supplementation is a great option for many people who want an alternative to prescription medications such as beta blockers or ACE inhibitors. This new study shows Pycnogenol® administers a therapeutic effect to limit the degenerative process in patients predisposed to congestive heart failure, such as the aged.”
The study was conducted at the University of Arizona, Tucson. Elderly female mice (18 months old) were randomly divided into four groups: control mice, mice receiving Pycnogenol® only, mice receiving L-NAME only (a substance which causes arterial constriction) and mice receiving both Pycnogenol® and L-NAME. Pycnogenol® and L-NAME were administered in tap water and the study was approved by the Animal Review Committee at the University of Arizona.
One group of hypertensive mice received Pycnogenol® in drinking water for four weeks and another group of hypertensive mice was left untreated. After five weeks, the hearts of the latter control group had significantly increased in size as a result of hypertension. In the Pycnogenol® treated group, hypertension and heart function parameters resembled those found in healthy control mice with healthy blood pressure.
“This study provides evidence that oral administration of Pycnogenol® reversed cardiovascular remodeling induced by L-NAME by blocking nitric oxide production, which leads to hypertension and finally cardiomyopathy,” said Watson.
After a detailed investigation of the heart tissue, Watson found Pycnogenol® supplementation to significantly enhance the connective collagen matrix of cardiac tissue. Whereas the chronic hypertension in mice led to a significant loss of connective collagen fibers, Pycnogenol® significantly increased the collagen presence, resulting in stronger cardiac chambers.
According to the American Heart Association nearly five million Americans are living with heart failure, and 550,000 new cases are diagnosed each year. The mortality rate for heart failure affects 80 percent of men and 70 percent of women within 12 years of obtaining cardiovascular diseases. According to Watson, cardiac remodeling is considered an important therapeutic target to battle this disease.
Watson presented the new research this month at the SupplySide East Educational Conference and Trade Show in Secaucus, NJ. Previous clinical research shows Pycnogenol® to battle coronary heart disease and stroke, high blood cholesterol and hypertension. Research shows Pycnogenol® to diminish the major cardiovascular risk factors simultaneously while offering a safe, natural approach.
http://www.ecenter.isotonix.com/
or
www.marketamerica.com/customizeme
Pycnogenol and OPC-3™
You've known about the beneficial ingredients in our top-selling Isotonix® OPC-3 for years. New research continues to indicate that a key OPC-3 ingredient, Pycnogenol, may offer powerful, significant benefits to those who take it.*
To find out more about Market America Isotonix® OPC-3™, go to "top ten products" (left column)>Isotonix® OPC-3™
www.CustomizeME.com
New Study: Pycnogenol® Reduces Heart Failure
May 16, 2007 – GENEVA, Switzerland – A study to be published in an upcoming edition of the journal of Cardiovascular Toxicology reveals Pycnogenol®, natural pine bark extract from the French maritime pine tree, helps prevent damage that high blood pressure causes to the heart. The study demonstrates Pycnogenol® counteracts the “wearing out” of the heart, which may aid the five million Americans living with heart failure. Previous studies have shown Pycnogenol® supplementation to be associated with improved cardiovascular health, such as cholesterol reduction, blood pressure control and prevention of thrombosis.
In hypertension, the over-worked heart gradually wears out, resulting in the weakening of the heart muscle and increasing of heart chamber volume. This process (known as cardiac remodeling) may eventually cause heart failure when the heart insufficiently supplies the body with oxygenated blood. The study showed that Pycnogenol® prevents the heart from getting worn out during hypertension. Cardiac chamber walls showed a significantly higher rate of collagen connective tissues than control groups.
“Alternative treatments such as Pycnogenol® are crucial components in the fight against heart disease,” said Dr. Ronald Watson, professor in the Department of Nutritional Sciences at the University of Arizona and a lead researcher of the study. “The effectiveness of Pycnogenol® supplementation is a great option for many people who want an alternative to prescription medications such as beta blockers or ACE inhibitors. This new study shows Pycnogenol® administers a therapeutic effect to limit the degenerative process in patients predisposed to congestive heart failure, such as the aged.”
The study was conducted at the University of Arizona, Tucson. Elderly female mice (18 months old) were randomly divided into four groups: control mice, mice receiving Pycnogenol® only, mice receiving L-NAME only (a substance which causes arterial constriction) and mice receiving both Pycnogenol® and L-NAME. Pycnogenol® and L-NAME were administered in tap water and the study was approved by the Animal Review Committee at the University of Arizona.
One group of hypertensive mice received Pycnogenol® in drinking water for four weeks and another group of hypertensive mice was left untreated. After five weeks, the hearts of the latter control group had significantly increased in size as a result of hypertension. In the Pycnogenol® treated group, hypertension and heart function parameters resembled those found in healthy control mice with healthy blood pressure.
“This study provides evidence that oral administration of Pycnogenol® reversed cardiovascular remodeling induced by L-NAME by blocking nitric oxide production, which leads to hypertension and finally cardiomyopathy,” said Watson.
After a detailed investigation of the heart tissue, Watson found Pycnogenol® supplementation to significantly enhance the connective collagen matrix of cardiac tissue. Whereas the chronic hypertension in mice led to a significant loss of connective collagen fibers, Pycnogenol® significantly increased the collagen presence, resulting in stronger cardiac chambers.
According to the American Heart Association nearly five million Americans are living with heart failure, and 550,000 new cases are diagnosed each year. The mortality rate for heart failure affects 80 percent of men and 70 percent of women within 12 years of obtaining cardiovascular diseases. According to Watson, cardiac remodeling is considered an important therapeutic target to battle this disease.
Watson presented the new research this month at the SupplySide East Educational Conference and Trade Show in Secaucus, NJ. Previous clinical research shows Pycnogenol® to battle coronary heart disease and stroke, high blood cholesterol and hypertension. Research shows Pycnogenol® to diminish the major cardiovascular risk factors simultaneously while offering a safe, natural approach.
http://www.ecenter.isotonix.com/
or
www.marketamerica.com/customizeme
Pycnogenol and OPC-3™
You've known about the beneficial ingredients in our top-selling Isotonix® OPC-3 for years. New research continues to indicate that a key OPC-3 ingredient, Pycnogenol, may offer powerful, significant benefits to those who take it.*
To find out more about Market America Isotonix® OPC-3™, go to "top ten products" (left column)>Isotonix® OPC-3™
www.CustomizeME.com
Vital Nutrients and the Benefits of Nutritional Supplements
Discover the Benefits of Nutritional Supplements
In modern times, there is a growing and important need to incorporate nutritional supplements in one's diet for many reasons. While the average person may believe that he or she is eating a balanced diet, in fact he or she may be missing out on vital nutrients that cannot be easily gained on a daily basis. There are several factors that need to be taken into consideration when one is weighing the reasons for taking supplements.
Why Take Nutritional Supplements?
Modern farming methods utilize frequent crop rotations in order to maximize productivity. As a result, however, vital nutrients and especially minerals in the soil are rapidly depleted. This is so extreme that you may notice that a tomato from the store today just doesn't taste like the tomato of your childhood - and it probably has nowhere near the nutrient level either. As a result, those eating mass-produced vegetables and fruits are missing out on key phytonutrients, including bioflavanoids and minerals, which are generally no longer present in the amounts they were in the past.
In addition, today we are constantly exposed to overly processed food products. If you walk into any standard supermarket, you would likely eliminate 90 percent of the store if you were to ignore the processed foods that are offered. It's certainly hard to avoid, since these are the products advertised on television, available at grocery stores, and served in the multitudes of fast-food restaurants. Even if you are conscientious and try to eat well, you still likely are filling your stomach much of the time with processed grains (stripped of bran and fiber), fatty foods (loaded with saturated and trans-fats) and overly sweetened foods with few vital nutrients.
Plus, it can be almost impossible to achieve the diverse and vital nutrients that your body requires just in what you eat day to day. For example, different fruits contain different nutrients - but you are not likely to eat every type of fruit every single day, or even once a month. How often have you eaten blueberries, bananas, pears, cherries and raspberries in a single day? Because there is such a variety out there, and because these nutrients are all important, it can be simply impossible to consistently get them all from diet alone.
Another challenge is that Americans are eating the wrong types of fats - we eat too many products containing high levels of trans fats, saturated fats, and vegetable poly unsaturated fats, instead of healthy monounsaturated fats and fish oils. Fish oils, in particular, are a valuable source of essential fatty acids, which are critical for maintaining normal mental and cardiovascular function. But unless one is eating wild Alaskan salmon three to four times a week, every week, one is not likely achieving the optimal level of these essential fatty acids and vital nutrients from diet alone.
For all of these reasons and more, high-quality nutritional supplements can help fill in the gaps and provide the vital nutrients missing from foods. They can give you the variety that you need on a day-to-day basis. Nutritional supplements are also important as it becomes evident that many vitamins and minerals can optimize your genetic potential - and taking nutritional supplements with the right blend of vital nutrients can also achieve this.
How Can You Choose the Right Nutritional Supplements?
Therefore, if taking nutritional supplements is so important to your health, your next step is to figure out how to navigate the sea of options that currently exist. Walk into any grocery store or pharmacy, or do an online search, and you'll find thousands of nutritional supplements. How do you choose a product or a brand?
Generally speaking, you should start by making sure that any supplement you buy is from a manufacturer and/or supplier working under Good Manufacturing Practices (GMP). These practices include documentation of the manufacturing process to eliminate the risks of i) contamination or adulteration of the vital nutrients the supplements contain, or ii) product mislabeling. Most well-known brands use GMP, so you may want to stick with a better-known product to ensure quality.
You can also investigate the manufacturer of a supplement to ensure that it has good quality control processes in place. The manufacturer should make this information available for consumers on its website or in product literature, including whether it has in-house testing of its products and whether it works with independent labs to confirm the potency and purity of its nutritional supplements and the vital nutrients that are included. In addition, you should be able to see up front if the manufacturer is promoting clinical research or simply featuring pseudo-science with little back up of its claims.
Take a look at the entire product line offered by the company as well. Many producers of nutritional supplements simply provide stand alone vitamins or single-ingredient herbs, such as a vitamin D supplement or an Echinacea pill. These companies are often simply of the "me too" variety - offering basic products just to make money. Other companies may offer blends or balanced formulations with the right combinations of vital nutrients such as vitamins, minerals, or herbs that work together to produce optimal results. Such companies are likely to provide balanced nutritional supplements that more closely mimic those found in nature and that are better for maintaining your health. Companies that provide such products are more likely to be interested in the overall well-being of their customers rather than in just selling a single type of ingredient.
Finally, look carefully at the delivery method of the vital nutrients in any supplement you are investigating. While many nutritional supplements are offered in a compressed tablet format, this is not necessarily the best way to get the nutrients into your system. If this type of tablet isn't formulated properly, or if it is compressed with too much pressure when it is created, it will not dissolve readily in the stomach. If you decide to try tablets, make sure the label notes that they meet USP dissolution requirements, which means that the product has been tested and will properly dissolve in the stomach.
A better choice for delivery is to find nutritional supplements that are isotonic - provided in powder form that can be mixed with water to create an isotonic solution. This enables vital nutrients to be absorbed more readily in the small bowel without need for digestion in the stomach, thus a very efficient delivery method.
Conclusion
Nutritional supplements can be extremely beneficial to your overall health and well being and can compensate for the lack of vital nutrients in modern processed foods and inadequate diets. However, it is important to choose very carefully the nutritional supplements that you purchase. Look into the background of the manufacturer or supplier of the supplements and make sure they are meeting quality control standards as well as providing these vital nutrients in a delivery form that has the greatest benefit.
www.marketamerica.com/customizeme
or
www.CustomizeME.com
In modern times, there is a growing and important need to incorporate nutritional supplements in one's diet for many reasons. While the average person may believe that he or she is eating a balanced diet, in fact he or she may be missing out on vital nutrients that cannot be easily gained on a daily basis. There are several factors that need to be taken into consideration when one is weighing the reasons for taking supplements.
Why Take Nutritional Supplements?
Modern farming methods utilize frequent crop rotations in order to maximize productivity. As a result, however, vital nutrients and especially minerals in the soil are rapidly depleted. This is so extreme that you may notice that a tomato from the store today just doesn't taste like the tomato of your childhood - and it probably has nowhere near the nutrient level either. As a result, those eating mass-produced vegetables and fruits are missing out on key phytonutrients, including bioflavanoids and minerals, which are generally no longer present in the amounts they were in the past.
In addition, today we are constantly exposed to overly processed food products. If you walk into any standard supermarket, you would likely eliminate 90 percent of the store if you were to ignore the processed foods that are offered. It's certainly hard to avoid, since these are the products advertised on television, available at grocery stores, and served in the multitudes of fast-food restaurants. Even if you are conscientious and try to eat well, you still likely are filling your stomach much of the time with processed grains (stripped of bran and fiber), fatty foods (loaded with saturated and trans-fats) and overly sweetened foods with few vital nutrients.
Plus, it can be almost impossible to achieve the diverse and vital nutrients that your body requires just in what you eat day to day. For example, different fruits contain different nutrients - but you are not likely to eat every type of fruit every single day, or even once a month. How often have you eaten blueberries, bananas, pears, cherries and raspberries in a single day? Because there is such a variety out there, and because these nutrients are all important, it can be simply impossible to consistently get them all from diet alone.
Another challenge is that Americans are eating the wrong types of fats - we eat too many products containing high levels of trans fats, saturated fats, and vegetable poly unsaturated fats, instead of healthy monounsaturated fats and fish oils. Fish oils, in particular, are a valuable source of essential fatty acids, which are critical for maintaining normal mental and cardiovascular function. But unless one is eating wild Alaskan salmon three to four times a week, every week, one is not likely achieving the optimal level of these essential fatty acids and vital nutrients from diet alone.
For all of these reasons and more, high-quality nutritional supplements can help fill in the gaps and provide the vital nutrients missing from foods. They can give you the variety that you need on a day-to-day basis. Nutritional supplements are also important as it becomes evident that many vitamins and minerals can optimize your genetic potential - and taking nutritional supplements with the right blend of vital nutrients can also achieve this.
How Can You Choose the Right Nutritional Supplements?
Therefore, if taking nutritional supplements is so important to your health, your next step is to figure out how to navigate the sea of options that currently exist. Walk into any grocery store or pharmacy, or do an online search, and you'll find thousands of nutritional supplements. How do you choose a product or a brand?
Generally speaking, you should start by making sure that any supplement you buy is from a manufacturer and/or supplier working under Good Manufacturing Practices (GMP). These practices include documentation of the manufacturing process to eliminate the risks of i) contamination or adulteration of the vital nutrients the supplements contain, or ii) product mislabeling. Most well-known brands use GMP, so you may want to stick with a better-known product to ensure quality.
You can also investigate the manufacturer of a supplement to ensure that it has good quality control processes in place. The manufacturer should make this information available for consumers on its website or in product literature, including whether it has in-house testing of its products and whether it works with independent labs to confirm the potency and purity of its nutritional supplements and the vital nutrients that are included. In addition, you should be able to see up front if the manufacturer is promoting clinical research or simply featuring pseudo-science with little back up of its claims.
Take a look at the entire product line offered by the company as well. Many producers of nutritional supplements simply provide stand alone vitamins or single-ingredient herbs, such as a vitamin D supplement or an Echinacea pill. These companies are often simply of the "me too" variety - offering basic products just to make money. Other companies may offer blends or balanced formulations with the right combinations of vital nutrients such as vitamins, minerals, or herbs that work together to produce optimal results. Such companies are likely to provide balanced nutritional supplements that more closely mimic those found in nature and that are better for maintaining your health. Companies that provide such products are more likely to be interested in the overall well-being of their customers rather than in just selling a single type of ingredient.
Finally, look carefully at the delivery method of the vital nutrients in any supplement you are investigating. While many nutritional supplements are offered in a compressed tablet format, this is not necessarily the best way to get the nutrients into your system. If this type of tablet isn't formulated properly, or if it is compressed with too much pressure when it is created, it will not dissolve readily in the stomach. If you decide to try tablets, make sure the label notes that they meet USP dissolution requirements, which means that the product has been tested and will properly dissolve in the stomach.
A better choice for delivery is to find nutritional supplements that are isotonic - provided in powder form that can be mixed with water to create an isotonic solution. This enables vital nutrients to be absorbed more readily in the small bowel without need for digestion in the stomach, thus a very efficient delivery method.
Conclusion
Nutritional supplements can be extremely beneficial to your overall health and well being and can compensate for the lack of vital nutrients in modern processed foods and inadequate diets. However, it is important to choose very carefully the nutritional supplements that you purchase. Look into the background of the manufacturer or supplier of the supplements and make sure they are meeting quality control standards as well as providing these vital nutrients in a delivery form that has the greatest benefit.
www.marketamerica.com/customizeme
or
www.CustomizeME.com
Friday, May 04, 2007
Fish oil gives statins a boost
The March 31, 2007 issue of The Lancet published the finding of the Japan EPA Lipid Intervention Study (JELIS) that the omega-3 fatty acid eicosapentaenoic acid (EPA) found in fish oil could be used in addition to statin drugs to provide additional protection against coronary artery disease. The study is the first major long-term interventional trial to evaluate this effect.
Mitsuhiro Yokoyama of Kobe University Graduate School of Medicine and colleagues randomized 18,645 men and women with a total cholesterol of at least 6.5 micromoles per liter to receive 1800 milligrams EPA with a statin drug, or a statin drug only for a five year period during which major coronary events were noted. Serum cholesterol levels were measured at the beginning and conclusion of the trial.
At the end of an average 4.6 years of follow up, LDL cholesterol concentrations had decreased by an average of 25% in both groups. A 19 percent reduction in major coronary events occurred in the group that received EPA compared to those that received a statin only. Unstable angina and nonfatal events were similarly reduced.
“This study shows that EPA, at a dose of 1800 mg per day, is a very promising regimen for prevention of major coronary events, especially since EPA seems to act through several biological mechanisms," the authors conclude. "We need to investigate whether EPA is effective for prevention of major coronary events in hypercholesterolemic patients without or with coronary artery disease in other countries”.
“Compared with drugs, invasive procedures, and devices, modest dietary changes are low risk, inexpensive, and widely available," Dariush Mozaffarian of Harvard wrote in an accompanying commentary."The JELIS investigators should be commended, and their efforts should inspire additional clinical trials of the effects of fish oil and other dietary factors and habits on cardiovascular health”.
—D Dye
Mitsuhiro Yokoyama of Kobe University Graduate School of Medicine and colleagues randomized 18,645 men and women with a total cholesterol of at least 6.5 micromoles per liter to receive 1800 milligrams EPA with a statin drug, or a statin drug only for a five year period during which major coronary events were noted. Serum cholesterol levels were measured at the beginning and conclusion of the trial.
At the end of an average 4.6 years of follow up, LDL cholesterol concentrations had decreased by an average of 25% in both groups. A 19 percent reduction in major coronary events occurred in the group that received EPA compared to those that received a statin only. Unstable angina and nonfatal events were similarly reduced.
“This study shows that EPA, at a dose of 1800 mg per day, is a very promising regimen for prevention of major coronary events, especially since EPA seems to act through several biological mechanisms," the authors conclude. "We need to investigate whether EPA is effective for prevention of major coronary events in hypercholesterolemic patients without or with coronary artery disease in other countries”.
“Compared with drugs, invasive procedures, and devices, modest dietary changes are low risk, inexpensive, and widely available," Dariush Mozaffarian of Harvard wrote in an accompanying commentary."The JELIS investigators should be commended, and their efforts should inspire additional clinical trials of the effects of fish oil and other dietary factors and habits on cardiovascular health”.
—D Dye
Friday, April 27, 2007
Meta-analysis finds antioxidant supplementation safe during cancer therapy
April 20, 2007
Meta-analysis finds antioxidant supplementation safe during cancer therapy
The January/February and March/April 2007 issues of the journal Alternative Therapies published a two part article by a team at the Simone Protective Cancer Institute in Lawrenceville, New Jersey, which concluded that, contrary to long-held beliefs, antioxidant and other nutritional supplementation during chemotherapy or radiation does not interfere with these treatments.
"A single, front-page interview in The New York Times in 1997, which was not based on published scientific work, and a single research paper involving mice, along with a press release by its author in 1999, led to the erroneous notion that vitamin C interferes with chemotherapy and radiation in humans," the authors write. "This notion soon applied to all antioxidants as physicians, patients, the media, the American Cancer Society, and scores of websites took the same position without reviewing the scientific evidence."
For their meta-analysis, oncologist Charles B. Simone, MD, and colleagues identified 50 human studies that included a total of 8,251 participants involving the use of chemotherapy and/or radiation concurrently with dietary supplements. They discovered that antioxidants and other supplements failed to interfere with the treatments and were actually found to enhance them. In 47 of these studies, supplements were associated with protection of normal tissue and a reduction of side effects, and in 15 studies, 3,738 subjects experienced increased survival.
The authors explain that, due to a loss of the homeostasis control mechanism for the uptake of antioxidants, cancer cells accumulate large amounts of the nutrients, while healthy cells do not have this membrane defect. This accumulation decreases the oxidative reactions needed for the generation of the cells' energy. Additionally, the nutrients elicit other effects on cancer cells unrelated to their antioxidant activity.
The authors concluded that "Antioxidant and other nutrient food supplements are safe and can help to enhance cancer patient care."
Meta-analysis finds antioxidant supplementation safe during cancer therapy
The January/February and March/April 2007 issues of the journal Alternative Therapies published a two part article by a team at the Simone Protective Cancer Institute in Lawrenceville, New Jersey, which concluded that, contrary to long-held beliefs, antioxidant and other nutritional supplementation during chemotherapy or radiation does not interfere with these treatments.
"A single, front-page interview in The New York Times in 1997, which was not based on published scientific work, and a single research paper involving mice, along with a press release by its author in 1999, led to the erroneous notion that vitamin C interferes with chemotherapy and radiation in humans," the authors write. "This notion soon applied to all antioxidants as physicians, patients, the media, the American Cancer Society, and scores of websites took the same position without reviewing the scientific evidence."
For their meta-analysis, oncologist Charles B. Simone, MD, and colleagues identified 50 human studies that included a total of 8,251 participants involving the use of chemotherapy and/or radiation concurrently with dietary supplements. They discovered that antioxidants and other supplements failed to interfere with the treatments and were actually found to enhance them. In 47 of these studies, supplements were associated with protection of normal tissue and a reduction of side effects, and in 15 studies, 3,738 subjects experienced increased survival.
The authors explain that, due to a loss of the homeostasis control mechanism for the uptake of antioxidants, cancer cells accumulate large amounts of the nutrients, while healthy cells do not have this membrane defect. This accumulation decreases the oxidative reactions needed for the generation of the cells' energy. Additionally, the nutrients elicit other effects on cancer cells unrelated to their antioxidant activity.
The authors concluded that "Antioxidant and other nutrient food supplements are safe and can help to enhance cancer patient care."
Wednesday, April 04, 2007
Pine bark extract shows promise for slowing sugar uptake
By Stephen Daniells
2/9/2007 - Extracts from French maritime pine bark may inhibit an enzyme linked to glucose absorption 190 times more than a synthetic medication, says new research from Germany that could offer significant benefits for diabetics if the results can be translated from the lab to humans.The results of the new study, published on-line in the Elsevier journal Diabetes Research and Clinical Practice, add to a growing body of research reporting anti-diabetic effects of the pine bark extract, Pycnogenol.
"Diabetes mellitus type II is a serious disease with rising prevalence," said lead researcher Dr. Petra Hogger. "This study is crucial for those suffering with the disease because it affirms that Pycnogenol is more effective than [a] prescription medication and supports the abundance of other research done on Pycnogenol and diabetes."
An estimated 19 million people are affected by diabetes in the EU 25, equal to four per cent of the total population. This figure is projected to increase to 26 million by 2030.
In the US, there are over 20 million people with diabetes, equal to seven per cent of the population. The total costs are thought to be as much as $132 bn, with $92 bn being direct costs from medication, according to 2002 American Diabetes Association figures.
Hogger and co-researcher Angelika Schafer from Wurzburg University tested Pycnogenol, a green tea extract (Emil Flachsmann) and the synthetic compound acabrose (Glucobay, Bayer Vital) for their ability to inhibit alpha-glucosidase, an enzyme found in the large intestine that is involved in the metabolism of carbohydrates and the production of glucose.
By inhibiting the activity of the enzyme it could be possible to prevent typical high-glucose peaks in the blood stream after a meal.
The in vitro study used an assay of alpha-glucosidase activity with equal concentrations of each sample and report that the most potent inhibition of the alpha-glucosidase was achieved by the pine bark extract (quantity required 50 per cent inhibition five micrograms per millilitre), followed by the green tea extract (20 micrograms per millilitre) and finally the acarbose (one milligram per millilitre).
"Since the alpha-glucosidase enzymes are located in the duodenum the intact pine bark extract constituents could exert inhibitory effects on alpha-glucosidase before a secondary metabolism of the procyanidin oligomers by bacteria occurs of the lower intestinal tract," wrote the researchers.
"Our results contribute to the explanation of clinical anti-diabetic effects of Pycnogenol," they said.
To identify which compounds in Pycnogenol may be behind the inhibiting effects, the researchers tested four different fractions (phenol carbonic acids and monomeric polyphenols; dimeric and trimeric procyanidins; tetrameric up to hexameric procyanidins; and higher oligomeric compounds).
The latter of these fractions inhibited the enzyme's activity by 94 per cent.
"The results obtained assign a novel, local effect to oligomeric procyanidins and contribute to the explanation of glucose-lowering effects of Pycnogenol observed in clinical trials with diabetic patients," wrote the researchers.
The actual mechanism by which these oligomeric procyanidins inhibit alpha-glucosidase is not clear, and more research is needed to elucidate these effects. Additional in vivo studies are needed to support these effects.
Horphag Research, manufacturer of Pycnogenol, has been very active in sponsoring and supporting studies into the potential health benefits of the pine bark extract and was the funding source behind this latest study.
The first research was conducted on the ingredient 35 years ago. Victor Ferrari, research chief operating officer and executive vice president of Horphag Research, told NutraIngredients recently that the company ploughs $1.5m - "most of its profits" - into research each year.
The product is extracted from the bark of the Maritime pine that grows on the southern coast of France, and is currently used in over 400 dietary supplements, multi-vitamins and health products.
Source: Diabetes Research and Clinical PracticePublished on-line ahead of print, doi: 10.1016/j.diabres.2006.10.011"Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol) effectively inhibit alpha-glucosidase"Authors: A. Schafer, P. Hogger
2/9/2007 - Extracts from French maritime pine bark may inhibit an enzyme linked to glucose absorption 190 times more than a synthetic medication, says new research from Germany that could offer significant benefits for diabetics if the results can be translated from the lab to humans.The results of the new study, published on-line in the Elsevier journal Diabetes Research and Clinical Practice, add to a growing body of research reporting anti-diabetic effects of the pine bark extract, Pycnogenol.
"Diabetes mellitus type II is a serious disease with rising prevalence," said lead researcher Dr. Petra Hogger. "This study is crucial for those suffering with the disease because it affirms that Pycnogenol is more effective than [a] prescription medication and supports the abundance of other research done on Pycnogenol and diabetes."
An estimated 19 million people are affected by diabetes in the EU 25, equal to four per cent of the total population. This figure is projected to increase to 26 million by 2030.
In the US, there are over 20 million people with diabetes, equal to seven per cent of the population. The total costs are thought to be as much as $132 bn, with $92 bn being direct costs from medication, according to 2002 American Diabetes Association figures.
Hogger and co-researcher Angelika Schafer from Wurzburg University tested Pycnogenol, a green tea extract (Emil Flachsmann) and the synthetic compound acabrose (Glucobay, Bayer Vital) for their ability to inhibit alpha-glucosidase, an enzyme found in the large intestine that is involved in the metabolism of carbohydrates and the production of glucose.
By inhibiting the activity of the enzyme it could be possible to prevent typical high-glucose peaks in the blood stream after a meal.
The in vitro study used an assay of alpha-glucosidase activity with equal concentrations of each sample and report that the most potent inhibition of the alpha-glucosidase was achieved by the pine bark extract (quantity required 50 per cent inhibition five micrograms per millilitre), followed by the green tea extract (20 micrograms per millilitre) and finally the acarbose (one milligram per millilitre).
"Since the alpha-glucosidase enzymes are located in the duodenum the intact pine bark extract constituents could exert inhibitory effects on alpha-glucosidase before a secondary metabolism of the procyanidin oligomers by bacteria occurs of the lower intestinal tract," wrote the researchers.
"Our results contribute to the explanation of clinical anti-diabetic effects of Pycnogenol," they said.
To identify which compounds in Pycnogenol may be behind the inhibiting effects, the researchers tested four different fractions (phenol carbonic acids and monomeric polyphenols; dimeric and trimeric procyanidins; tetrameric up to hexameric procyanidins; and higher oligomeric compounds).
The latter of these fractions inhibited the enzyme's activity by 94 per cent.
"The results obtained assign a novel, local effect to oligomeric procyanidins and contribute to the explanation of glucose-lowering effects of Pycnogenol observed in clinical trials with diabetic patients," wrote the researchers.
The actual mechanism by which these oligomeric procyanidins inhibit alpha-glucosidase is not clear, and more research is needed to elucidate these effects. Additional in vivo studies are needed to support these effects.
Horphag Research, manufacturer of Pycnogenol, has been very active in sponsoring and supporting studies into the potential health benefits of the pine bark extract and was the funding source behind this latest study.
The first research was conducted on the ingredient 35 years ago. Victor Ferrari, research chief operating officer and executive vice president of Horphag Research, told NutraIngredients recently that the company ploughs $1.5m - "most of its profits" - into research each year.
The product is extracted from the bark of the Maritime pine that grows on the southern coast of France, and is currently used in over 400 dietary supplements, multi-vitamins and health products.
Source: Diabetes Research and Clinical PracticePublished on-line ahead of print, doi: 10.1016/j.diabres.2006.10.011"Oligomeric procyanidins of French maritime pine bark extract (Pycnogenol) effectively inhibit alpha-glucosidase"Authors: A. Schafer, P. Hogger
Thursday, November 03, 2005
MARKET AMERICA INTRODUCES FIVE NEW GENETIC ASSESSMENT TESTS
GREENSBORO, N.C. (Nov. 3 2005) – Market America, a product brokerage and Internet marketing company specializing in One-to-One Marketing and Mass Customization, today announced the introduction of five new health assessments to its Gene SNP™ DNA Screening Analysis line. The new tests use nutrigenetic science to provide consumers with personalized health recommendations based on diet, lifestyle and genetic profile. In addition to the new assessments, the company has improved the Gene SNP Comprehensive panel, which includes five tests in one.
The five new Gene SNP DNA Screening Analysis panels focus on specific areas important to overall health: Antioxidation/Detoxification, Bone Health, Heart Health, Inflammation, and Insulin Sensitivity. Each test includes an easy-to-use cheek swab for collecting a DNA sample and a lifestyle questionnaire. After submitting the cheek swab and questionnaire, consumers receive a personalized, confidential health assessment based on their specific genetic profile. The report also includes a personalized Health Action Plan designed to help individuals make informed choices about their health. Consumers are encouraged to discuss the Health Action Plan with their physician.
Included in the personalized Health Action Plan is a nutritional supplement formula that can help consumers address issues identified in the report. The formula comes in a three-month supply of convenient travel-sized packets.
Nutrigenetics is the study of how a person’s genes, lifestyle and diet interact to affect overall health. Through advanced analysis of DNA and lifestyle questionnaire answers, Gene SNP DNA Screening tests can provide consumers with valuable health information allowing them to prepare and adjust for potential risks. By identifying variations in DNA, nutrigenetics allows consumers to lower their risks for specific conditions and diseases by altering lifestyle and diet to achieve optimal health.
Through a partnership with Market America, Sciona, a Boulder, Colo.-based pioneer in nutrigenetic research, provides DNA analysis and the Health Action Plans. Sciona uses a proprietary, patent-pending software program that utilizes complex algorithms to produce the Gene SNP reports from information gathered in the genetic analysis and diet and lifestyle questionnaire.
Gene SNP DNA Screening Analysis test kits are available through Market America’s independent distributors. To find a distributor visit the products page at marketamerica.com. Individual Gene SNP panels have a suggested retail price of $125.00. The comprehensive panel has a suggested retail price of $249.95. Prices include a test kit, DNA analysis and Health Action Plan.
ABOUT MARKET AMERICAMarket America’s unique business model combines the power of the Internet and One-to-One Marketing to sell innovative products and services through independent distributors around the world. Founded in 1992, the company has realized more than $1.5 billion in suggested retail sales. The company now has more than 110,000 independent distributors worldwide. In 2005, the company opened operations in Taiwan and plans further expansion into the Pacific Rim. More information is available at www.marketamerica.com.
ABOUT SCIONA Sciona is a privately held, international company that provides personalized health and nutrition recommendations based on an individual's diet, lifestyle and unique genetic profile. The Company has created a powerful set of tools that enable consumers to harness the scientific information uncovered in the Human Genome Project. Sciona is headquartered in Boulder, Colorado with offices in Europe, and research facilities in New Haven, Connecticut in the Yale University Research Park.# # #
The five new Gene SNP DNA Screening Analysis panels focus on specific areas important to overall health: Antioxidation/Detoxification, Bone Health, Heart Health, Inflammation, and Insulin Sensitivity. Each test includes an easy-to-use cheek swab for collecting a DNA sample and a lifestyle questionnaire. After submitting the cheek swab and questionnaire, consumers receive a personalized, confidential health assessment based on their specific genetic profile. The report also includes a personalized Health Action Plan designed to help individuals make informed choices about their health. Consumers are encouraged to discuss the Health Action Plan with their physician.
Included in the personalized Health Action Plan is a nutritional supplement formula that can help consumers address issues identified in the report. The formula comes in a three-month supply of convenient travel-sized packets.
Nutrigenetics is the study of how a person’s genes, lifestyle and diet interact to affect overall health. Through advanced analysis of DNA and lifestyle questionnaire answers, Gene SNP DNA Screening tests can provide consumers with valuable health information allowing them to prepare and adjust for potential risks. By identifying variations in DNA, nutrigenetics allows consumers to lower their risks for specific conditions and diseases by altering lifestyle and diet to achieve optimal health.
Through a partnership with Market America, Sciona, a Boulder, Colo.-based pioneer in nutrigenetic research, provides DNA analysis and the Health Action Plans. Sciona uses a proprietary, patent-pending software program that utilizes complex algorithms to produce the Gene SNP reports from information gathered in the genetic analysis and diet and lifestyle questionnaire.
Gene SNP DNA Screening Analysis test kits are available through Market America’s independent distributors. To find a distributor visit the products page at marketamerica.com. Individual Gene SNP panels have a suggested retail price of $125.00. The comprehensive panel has a suggested retail price of $249.95. Prices include a test kit, DNA analysis and Health Action Plan.
ABOUT MARKET AMERICAMarket America’s unique business model combines the power of the Internet and One-to-One Marketing to sell innovative products and services through independent distributors around the world. Founded in 1992, the company has realized more than $1.5 billion in suggested retail sales. The company now has more than 110,000 independent distributors worldwide. In 2005, the company opened operations in Taiwan and plans further expansion into the Pacific Rim. More information is available at www.marketamerica.com.
ABOUT SCIONA Sciona is a privately held, international company that provides personalized health and nutrition recommendations based on an individual's diet, lifestyle and unique genetic profile. The Company has created a powerful set of tools that enable consumers to harness the scientific information uncovered in the Human Genome Project. Sciona is headquartered in Boulder, Colorado with offices in Europe, and research facilities in New Haven, Connecticut in the Yale University Research Park.# # #
Tuesday, October 11, 2005
Cleveland Clinic > Neuroscience > Professional Information > News > Stroke, Hemorrhage and Neurocritical Care
Cleveland Clinic > Neuroscience > Professional Information > News > Stroke, Hemorrhage and Neurocritical Care
The "French Paradox" - Cleveland Clinic Researchers Study Beneficial Effects of Red Wine in Stroke
Since neurons are extremely vulnerable to ischemia (i.e. interruption of cerebral blood flow), compared with other cell types, such as glia and endothelial cells, most strategies for ischemic stroke therapy have been directed toward neuronal protection. However, such efforts have not succeeded in clinical trials. Currently, the only approved medical treatment for acute stroke is intravenous injection of tissue-type plasminogen activator (tPA) which aims primarily to restore cerebral blood flow by dissolving blood clot materials. This therapy is limited by a short window of opportunity in terms of time between the onset of a stroke's evolution and the start of treatment. Also, intracerebral hemorrhage is a potential morbid side effect.
Recently, new therapeutic strategies have been considered for stroke that target mechanisms of brain tissue injury mediated by other cellular types, including endothelial and inflammatory cells. Part of The Cleveland Clinic's basic stroke research program has been focusing on the molecular aspect of brain tissue injury resulting from ischemic stroke. This research seeks a molecular target to treat stroke. Using wild-type or genetically-modified animal models where focal ischemia has been induced by intraluminal filament insertion techniques (see Illustration, right), researchers are able to dissect the mechanisms of brain tissue injury resulting from ischemia.
Recently, Clinic researchers discovered that resveratrol, a polyphenol that is abundant in red wine, strongly activates the peroxisome proliferator-activated receptor (PPAR) á and ã.PPARs are members of the nuclear hormone receptor family of ligand-dependent transcription factors. In agreement with clinical studies of the "French paradox," it was found that daily oral administration of resveratrol protects the brain against focal cerebral ischemia in laboratory models. This data suggests that PPARs may be a potential target to develop drugs that mimic the beneficial effects of red wine.
For more information, please call Shobu Namura, M.D., Ph.D., Department of Neurological Surgery, at 216/444-5672
The "French Paradox" - Cleveland Clinic Researchers Study Beneficial Effects of Red Wine in Stroke
Since neurons are extremely vulnerable to ischemia (i.e. interruption of cerebral blood flow), compared with other cell types, such as glia and endothelial cells, most strategies for ischemic stroke therapy have been directed toward neuronal protection. However, such efforts have not succeeded in clinical trials. Currently, the only approved medical treatment for acute stroke is intravenous injection of tissue-type plasminogen activator (tPA) which aims primarily to restore cerebral blood flow by dissolving blood clot materials. This therapy is limited by a short window of opportunity in terms of time between the onset of a stroke's evolution and the start of treatment. Also, intracerebral hemorrhage is a potential morbid side effect.
Recently, new therapeutic strategies have been considered for stroke that target mechanisms of brain tissue injury mediated by other cellular types, including endothelial and inflammatory cells. Part of The Cleveland Clinic's basic stroke research program has been focusing on the molecular aspect of brain tissue injury resulting from ischemic stroke. This research seeks a molecular target to treat stroke. Using wild-type or genetically-modified animal models where focal ischemia has been induced by intraluminal filament insertion techniques (see Illustration, right), researchers are able to dissect the mechanisms of brain tissue injury resulting from ischemia.
Recently, Clinic researchers discovered that resveratrol, a polyphenol that is abundant in red wine, strongly activates the peroxisome proliferator-activated receptor (PPAR) á and ã.PPARs are members of the nuclear hormone receptor family of ligand-dependent transcription factors. In agreement with clinical studies of the "French paradox," it was found that daily oral administration of resveratrol protects the brain against focal cerebral ischemia in laboratory models. This data suggests that PPARs may be a potential target to develop drugs that mimic the beneficial effects of red wine.
For more information, please call Shobu Namura, M.D., Ph.D., Department of Neurological Surgery, at 216/444-5672
CNN.com - Study: Fish-eaters stay sharper with age - Oct 10, 2005
CNN.com - Study: Fish-eaters stay sharper with age - Oct 10, 2005
Study: Fish-eaters stay sharper with age
Researchers say one meal a week slows decline by 10 percent
Monday, October 10, 2005; Posted: 4:13 p.m. EDT (20:13 GMT)
CHICAGO, Illinois (AP) -- Eating fish at least once a week is good for the brain, slowing age-related mental decline by the equivalent of three to four years, a study suggests.
The research adds to the growing evidence that a fish-rich diet helps keep the mind sharp. Previous studies found that people who ate fish lowered their risk of Alzheimer's disease and stroke. Fish such as salmon and tuna that are rich in omega-3 fatty acids also have been shown to prevent heart disease.
For the new study, researchers measured how well 3,718 people did on simple tests, such as recalling details of a story. The participants, all Chicago residents 65 and older, took the tests three times over six years. They also filled out a questionnaire about what they ate that included 139 foods.
"We found that people who ate one fish meal a week had a 10 percent slower annual decline in thinking," said co-author Martha Clare Morris, an epidemiologist at Rush University Medical Center. "Those who ate two fish meals a week showed a 13 percent slower annual decline."
The study was posted Monday on the Web site of the Archives of Neurology and will appear in the journal's December issue. It was published early online because of its general interest.
The researchers looked for, but failed to find, a link between omega-3 fatty acids and protection from brain decline. Previous studies found such a link.
Morris said it is possible that something else about eating fish worked to keep people's minds sharp. Or the food questionnaire might have been too broad to allow researchers to estimate omega-3 intakes accurately, said Dr. Pascale Barberger-Gateau, who does similar research at the University of Bordeaux in France but was not involved in the current study.
In the questionnaire, "only four seafood items were included, which did not allow this distinction," Barberger-Gateau said in an e-mail.
The questionnaire included four broad seafood categories: tuna fish sandwich; fish sticks/fish cakes/fish sandwich; fresh fish as a main dish; and shrimp/lobster/crab.
Testing participants' blood for omega-3 fatty acids would have given a more definitive measure, said Dr. William E. Connor of the Clinical Nutrition Department of Medicine at Oregon Health & Science University. He was not involved in the study.
Copyright 2005 The Associated Press. All rights reserved.This material may not be published, broadcast, rewritten, or redistributed
Study: Fish-eaters stay sharper with age
Researchers say one meal a week slows decline by 10 percent
Monday, October 10, 2005; Posted: 4:13 p.m. EDT (20:13 GMT)
CHICAGO, Illinois (AP) -- Eating fish at least once a week is good for the brain, slowing age-related mental decline by the equivalent of three to four years, a study suggests.
The research adds to the growing evidence that a fish-rich diet helps keep the mind sharp. Previous studies found that people who ate fish lowered their risk of Alzheimer's disease and stroke. Fish such as salmon and tuna that are rich in omega-3 fatty acids also have been shown to prevent heart disease.
For the new study, researchers measured how well 3,718 people did on simple tests, such as recalling details of a story. The participants, all Chicago residents 65 and older, took the tests three times over six years. They also filled out a questionnaire about what they ate that included 139 foods.
"We found that people who ate one fish meal a week had a 10 percent slower annual decline in thinking," said co-author Martha Clare Morris, an epidemiologist at Rush University Medical Center. "Those who ate two fish meals a week showed a 13 percent slower annual decline."
The study was posted Monday on the Web site of the Archives of Neurology and will appear in the journal's December issue. It was published early online because of its general interest.
The researchers looked for, but failed to find, a link between omega-3 fatty acids and protection from brain decline. Previous studies found such a link.
Morris said it is possible that something else about eating fish worked to keep people's minds sharp. Or the food questionnaire might have been too broad to allow researchers to estimate omega-3 intakes accurately, said Dr. Pascale Barberger-Gateau, who does similar research at the University of Bordeaux in France but was not involved in the current study.
In the questionnaire, "only four seafood items were included, which did not allow this distinction," Barberger-Gateau said in an e-mail.
The questionnaire included four broad seafood categories: tuna fish sandwich; fish sticks/fish cakes/fish sandwich; fresh fish as a main dish; and shrimp/lobster/crab.
Testing participants' blood for omega-3 fatty acids would have given a more definitive measure, said Dr. William E. Connor of the Clinical Nutrition Department of Medicine at Oregon Health & Science University. He was not involved in the study.
Copyright 2005 The Associated Press. All rights reserved.This material may not be published, broadcast, rewritten, or redistributed
Market America Launches First Fully Customizable Dietary Supplement
GREENSBORO, N.C. (October 10, 2005) – Market America, a product brokerage and Internet marketing company specializing in One-to-One Marketing and Mass Customization, today announced the introduction of Isotonix® Custom Cocktail. The new custom cocktail gives customers the ability to design a custom blend of up to 10 Isotonix-brand supplements in one, easy-to-use 90-day supply. Market America’s best-selling line of Isotonix-brand dietary supplements use an advanced, isotonic formula for maximum effectiveness through faster delivery.
Isotonix Custom Cocktail is the latest product to join the ranks of mass customization advances. Only recently has technology been developed that allows manufacturers and marketers to stray from mass-production models. Consumers are now able to order custom shoes, computers, clothes, bicycles and even cars online. Creating the technology that would allow Market America’s more than 1 million preferred customers to order a custom dietary supplement presented a very different set of challenges for the company.
To accommodate over 3.6 million possible combinations, Market America developed a dual-purpose Internet-based technology. “From a programming aspect, the sheer size of this was mind-boggling,” said Kevin Buckman, information systems vice president. “Offering custom products is one thing, but when there are that many possible combinations, technology has only progressed so far. We had to build this from the ground up. We also had to keep in mind that we were dealing with nutritional supplements. So, we built in a method to actively monitor the customer’s input and help provide a balanced nutritional blend.”
The newly developed technology allows customers to choose from up to 10 Isotonix components while also receiving nutritional advice about their unique blend. As customers build their own Isotonix Custom Cocktail, a chart indicates the percentage Daily Value of essential vitamins and minerals, suggesting a well-rounded dietary supplement.
The idea for Isotonix Custom Cocktail sprang not from a marketing executive but from surveys of Market America’s customers and independent distributors. The company has consistently used customer relationship management and data mining techniques to find out what its customers want and need.
“We continuously survey our customers for input,” said James Ridinger, Market America’s president and CEO. “We know that the majority of our customers take at least four Isotonix products daily. Many of our customers take double servings of certain products as a way to suit their personal supplement needs. The vast majority of those we surveyed indicated that they wanted an all-in-one product. Isotonix Custom Cocktail is a direct result of our ongoing dialogue with our customers.”
Market America’s business model relies on the information and feedback that comes from intimate relationships with customers. The company has more than 110,000 independent distributors around the world that maintain a one-to-one relationship with each of their customers. Isotonix Custom Cocktail is available through Market America’s independent distributors. To find a local distributor, visit marketamerica.com or call (800) 862-6561.
ABOUT MARKET AMERICA
Market America’s unique business model combines the power of the Internet and One-to-One Marketing to sell innovative products and services through independent distributors around the world. Founded in 1992, the company has realized more than $1.5 billion in suggested retail sales. The company now has more than 110,000 independent distributors worldwide. In 2005, the company opened operations in Taiwan and plans further expansion into the Pacific Rim. More information is available at www.marketamerica.com. # # #
Isotonix Custom Cocktail is the latest product to join the ranks of mass customization advances. Only recently has technology been developed that allows manufacturers and marketers to stray from mass-production models. Consumers are now able to order custom shoes, computers, clothes, bicycles and even cars online. Creating the technology that would allow Market America’s more than 1 million preferred customers to order a custom dietary supplement presented a very different set of challenges for the company.
To accommodate over 3.6 million possible combinations, Market America developed a dual-purpose Internet-based technology. “From a programming aspect, the sheer size of this was mind-boggling,” said Kevin Buckman, information systems vice president. “Offering custom products is one thing, but when there are that many possible combinations, technology has only progressed so far. We had to build this from the ground up. We also had to keep in mind that we were dealing with nutritional supplements. So, we built in a method to actively monitor the customer’s input and help provide a balanced nutritional blend.”
The newly developed technology allows customers to choose from up to 10 Isotonix components while also receiving nutritional advice about their unique blend. As customers build their own Isotonix Custom Cocktail, a chart indicates the percentage Daily Value of essential vitamins and minerals, suggesting a well-rounded dietary supplement.
The idea for Isotonix Custom Cocktail sprang not from a marketing executive but from surveys of Market America’s customers and independent distributors. The company has consistently used customer relationship management and data mining techniques to find out what its customers want and need.
“We continuously survey our customers for input,” said James Ridinger, Market America’s president and CEO. “We know that the majority of our customers take at least four Isotonix products daily. Many of our customers take double servings of certain products as a way to suit their personal supplement needs. The vast majority of those we surveyed indicated that they wanted an all-in-one product. Isotonix Custom Cocktail is a direct result of our ongoing dialogue with our customers.”
Market America’s business model relies on the information and feedback that comes from intimate relationships with customers. The company has more than 110,000 independent distributors around the world that maintain a one-to-one relationship with each of their customers. Isotonix Custom Cocktail is available through Market America’s independent distributors. To find a local distributor, visit marketamerica.com or call (800) 862-6561.
ABOUT MARKET AMERICA
Market America’s unique business model combines the power of the Internet and One-to-One Marketing to sell innovative products and services through independent distributors around the world. Founded in 1992, the company has realized more than $1.5 billion in suggested retail sales. The company now has more than 110,000 independent distributors worldwide. In 2005, the company opened operations in Taiwan and plans further expansion into the Pacific Rim. More information is available at www.marketamerica.com. # # #
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