Resveratrol shows potential for blood sugar

Resveratrol shows potential for blood sugar

Three months of consuming a daily supplement of resveratrol may help with blood sugar control and improve blood pressure in type­2 diabetics, suggests data from India.

“The results of the present study support our hypothesis that resveratrol supplementation improves glycemic control and the associated risk factors in patients with type 2 diabetes mellitus,” wrote researchers in Nutrition Research .
“The study also suggests that resveratrol could be used as an effective adjuvant therapy with a conventional hypoglycemic regimen to treat type 2 diabetes mellitus.”

Resveratrol, a powerful polyphenol and anti­fungal chemical, is often touted as the bioactive compound in grapes and red wine, and has particularly been associated with the so­called 'French Paradox'. The phrase, coined in 1992 by Dr Serge Renaud from Bordeaux University, describes the low incidence of heart disease and obesity among the French, despite their relatively high­fat diet and levels of wine consumption.
Other studies with only resveratrol have reported anti­cancer effects, anti­inflammatory effects, cardiovascular benefits, anti­diabetes potential, energy endurance enhancement, and protection against Alzheimer’s.

“To the best of our knowledge, this is the first clinical study to evaluate the effect of resveratrol as supplement in Indian patients with type­2 diabetes,” wrote the researchers. The potential mechanism behind the benefits is not clear, they added, and additional research is needed to elucidate the mechanism.
“Oral supplementation of resveratrol is thus found to be effective in improving glycemic control and may possibly provide a potential adjuvant for the treatment and management of diabetes,” they concluded.  

Isotonix Resveratrol

What Makes Isotonix® Resveratrol Unique?   

Poor cellular and cardiovascular health is becoming a worldwide epidemic. An unhealthy diet of processed, high-calorie, high-fat foods, pollution, smoking and sedentary lifestyles all contribute to poor cell and heart health. Scientists revealed The French Paradox, which states that even though the French drink, smoke and eat high-fat foods they have some of the lowest incidences of poor cardiovascular and cellular health. Scientists attribute this to the large amounts of red wine that the French consume or, more importantly, an extract found in red wine: resveratrol. Resveratrol is an ingredient with incredible clinical research, revealing that it supports cardiovascular and normal cell health. Because wine is so highly processed, the actual amount of resveratrol is quite low. One would have to drink at least three bottles of red wine a day to experience the effects of resveratrol extract. Additionally, the content of resveratrol in red wine is inconsistent and varies by type of wine, region and processing techniques. Resveratrol extract or more specifically, Resveravine®, which is a more concentrated form of resveratrol, ensures that the body reaps all of the benefits of resveratrol, without the ill effects from three bottles of wine.*

Isotonix® Resveratrol is an isotonic-capable supplement, made from three patented ingredients: Resveravine with 20% resveratrol extract, BioVin® Advanced with 5% resveratrol extract, and VitaBlue® (wild blueberry extract), designed to promote normal cell health. Isotonix Resveratrol works to maintain cell health, promote normal cell cycle activity, promote apoptosis (programmed cell death) in unhealthy cells, support the normal activity of the SIRT-1 gene, and promote cardiovascular health, by promoting healthy platelet activity, promoting vasorelaxation, and providing antioxidant protection of LDL particles. Resveravine is a combination of trans-resveratrol (20% purity) and viniferin extracted from vine stems, which work synergistically to enhance the effectiveness of resveratrol extract.Trans-resveratrol is the predominate isomer found in red wine grapes and juice, and Resveravine is 100 to 300 times more concentrated in trans-resveratrol than other products from grape skin. According to the Linus Pauli

Primary Benefits of Isotonix® Resveratrol*:

• Maintains cell health
• Promotes normal cell cycle activity
• Promotes apoptosis (programmed cell death) in unhealthy cells
• Promotes normal nuclear factor kappa B (NF-Kappa B – protein) and cyclooxygenase-2 (COX-2 - enzyme) activity
• Promotes normal activity of the SIRT-1 gene (involved in calorie restriction, fat mobilization, mitochondrial function)
• Promotes cardiovascular health (promotes normal platelet activity, helps maintain normal vasorelaxation, provides antioxidant protection of LDL particles).
• Superior antioxidant and high ORAC value
• Promotes a healthy prostate gland
• Helps promote apoptosis in unhealthy prostate cells

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Omega-3s tied to lower risk of heart arrhythmia

By Kerry Grens

NEW YORK | Wed Feb 1, 2012 1:17pm EST

(Reuters Health) - In a new study of some 3,000 older adults, those with the highest levels of omega-3 fatty acids in their blood were 30 percent less likely to develop an irregular heartbeat over the next 14 years than peers with the lowest blood levels of omega-3s.

"A 30 percent lower risk of the most common chronic arrhythmia in the United States population is a pretty big effect," said Dr. Dariush Mozaffarian, senior author of the new report and a professor at the Harvard School of Public Health.

According to some estimates, up to nine percent of Americans will develop atrial fibrillation, a heart-rhythm abnormality that can lead to stroke and heart failure, by the time they reach their 80s.

There are few treatments for the condition and they largely center on preventing strokes with blood-thinning drugs.

Some previous studies have suggested that people who eat a lot of fish have a lower risk of developing atrial fibrillation to begin with. But others haven't found the same link.

The omega-3 fatty acids measured in the new study -- eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA) - are found in oily fish and some enriched foods, like eggs, as well as in fish oil supplements.

The earlier studies relied on questionnaires about how much fish people ate, which can only estimate the levels of omega-3s they ingested, Mozaffarian noted.

"Any given fish species can vary in its omega-3s by 10-fold," he told Reuters Health.

To get a more accurate measurement of how much fish oil the people in the study actually ingested, the researchers sampled blood from more than 3,300 adults over age 65.

Over 14 years, they tracked the seniors' health and found that 789 had developed atrial fibrillation.

Those with top-25-percent omega-3 levels in their bloodstreams at the beginning of the study were about 30 percent less likely to end up with the arrhythmia compared to those with bottom-25-percent blood levels of the fatty acids.

The difference in risk isn't huge, but "these are meaningful reductions in risk" said Dr. Alvaro Alonso, a professor at the University of Minnesota School of Public Health who was not involved in this study.

A 30 percent reduction in risk would mean that instead of 25 out of every 100 people developing a condition, only about 17 out of every 100 people would get it.

Another study from Finland used the same approach of measuring fatty acids in the blood and found a similar reduction in the risk of atrial fibrillation among those with the highest levels.

Mozaffarian's group tried to tease out which of the omega-3 fats might be responsible for the lower risk, and found that high DHA levels were linked to a 23 percent lower risk for atrial fibrillation while EPA and DPA were not tied to any reduced risk.

DHA is highly concentrated in heart muscle cell membranes, Mozaffarian and his colleagues point out in their report, published in the journal Circulation.

Alonso cautioned that this study doesn't prove eating fish is responsible for the lower rate of atrial fibrillation, but he said there is some idea that the fatty acids found in fish could work by stabilizing the excitability of heart muscle cells.

He said that the results seem promising enough to warrant further studies experimenting with using fish oil as a potential preventive measure against atrial fibrillation.

An earlier study of fish oil pills found that they didn't help the symptoms of atrial fibrillation in people who had already developed the arrhythmia (see Reuters Health story of November 15, 2010).

The American Heart Association, the U.S. Department of Agriculture and other groups recommend eating fish at least twice a week.

Mozaffarian said most Americans don't meet those goals.

He said his study "doesn't change current guidelines, but I think this should change people's motivation."

Resveratrol helps cancer cells overcome resistance to common drug

From www.LEF.org
Resveratrol helps cancer cells overcome resistance to common drug
Feb 21, 2011
An article published in the February 28, 2011 issue of the journal Cancer Letters reports the finding of researchers at Ohio’s Cleveland Clinic of a benefit for resveratrol in suppressing the growth of breast cancer tumor cells that have become resistant to the drug rapamycin, an immunosuppression drug that has been used to treat cancer.  Results from other research involving resveratrol, a compound found in red wine, grapes and other plant foods, suggest an anticancer effect for several types of malignancies. 

A team led by Charis Eng, MD, PhD, who is the Chair of the Genomic Medicine Institute of Cleveland Clinic’s Lerner Research Institute tested the effect of resveratrol and rapamycin separately and in varying combinations on three human breast cancer cell lines.  They found dose-dependent effects for both compounds and an additive effect for a combination of the two, which induced 50 percent growth inhibition in all lines when administered in low concentrations.  It was determined that a tumor suppressing gene known as PTEN contributes to resveratrol’s growth suppressive effects.

"Rapamycin has been used in clinical trials as a cancer treatment,” Dr Eng stated.  “Unfortunately, after a while, the cancer cells develop resistance to rapamycin."

"Our findings show that resveratrol seems to mitigate rapamycin-induced drug resistance in breast cancers, at least in the laboratory,” she reported. “ If these observations hold true in the clinic setting, then enjoying a glass of red wine or eating a bowl of boiled peanuts – which has a higher resveratrol content than red wine – before rapamycin treatment for cancer might be a prudent approach."
For more information about Resveratrol click here

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